Wenxin Dong's research while affiliated with Fudan University and other places
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Publication (1)
Background
Photodynamic therapy (PDT) with hemoporfin (hematoporphyrinmonomethyl ether, HMME) and 532 nm continuous-wave lasers is effective for port-wine stains (PWS) and is considered as a promising treatment modality. The vascular endothelial growth factor (VEGF) is involved in the development of PWS. This study aimed to investigate the effect o...
Citations
... Furthermore, PDT caused a complete inhibition of tube formation ability of the HEC-1-A cells upon VEGF stimulation, confirming the antiangiogenic effects of PDT. In the same way, PDT using the porphyrin derivative hematoporphyrinmonomethyl ether (HMME), illuminated either at 410 or 532 nm, resulted in a light-and photosensitizer dose-dependent VEGFR-2 downregulation in human umbilical vein endothelial cells [96,97].Taken together, PDT appears to prevent rapid regrowth of vascular endothelial cells by reducing VEGFR-2 signaling. ...
