Wenqiang Xiong's research while affiliated with Nanchang University and other places
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Publications (5)
Background and objectives
Despite being clinically utilized for the treatment of infections, the limited therapeutic range of polymyxin B (PMB), along with considerable interpatient variability in its pharmacokinetics and frequent occurrence of acute kidney injury, has significantly hindered its widespread utilization. Recent research on the popula...
Ursolic acid (UA), a pentacyclic triterpenoid, exhibits various pharmacological actions, such as anti-inflammation, anti-tumor, anti-diabetes, heart protection, and liver protection. However, the role of nuclear factor E2-related factor 2 (NRF2)-mediated regulation of uridine diphosphate glucuronosyltransferase (UGT2B7) and bile salt export pump (B...
Human hepatoblastoma cell line HepG2 has been widely used in the study of liver and liver cancer. α-naphthyl-isothiocyanate (ANIT) is a poison widely used in rodents to simulate human intrahepatic cholestasis. Ursolic acid (UA), a pentacyclic triterpenoid, exhibits various pharmacological actions. However, the role of nuclear factor E2 related fact...
A simple, rapid, sensitive and specific LC-MS/MS method was developed and validated for the quantitative determination of doxylamine in human plasma, using isotope doxylamine-d5 as internal standard (IS). The detection was conducted on a QTRAP 5500 tandem mass spectrometer coupled with electrospray ionization (ESI) source in positive ion mode. Quan...
