Wen-ya Huang's research while affiliated with Tongji Hospital and other places
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Publications (5)
Thioredoxin reductase 1 (TXNRD1) is one of the major redox regulators in mammalian cells, which has been reported to be involved in tumorigenesis. However, its roles and regulatory mechanism underlying the progression of HCC remains poorly understood. In this study, we demonstrated that TXNRD1 was significantly upregulated in HCC tumor tissues and...
Positive nucleic acid (NA) results have been found in recovered and discharged COVID-19 patients, but the proportion is unclear. This study was designed to analyze the recurrent positive rate of NA results after consecutively negative results, and the relationship between the specific antibody production and positive NA rate. According to Strengthe...
It has been well known that insomnia and sleep deprivation can lead to many metabolic diseases such as type 2 diabete mellitus (T2DM). Chinese medicine (CM) has been used to improve insomnia and showed many good therapeutic effects. Some Coptidis Rhizoma-contained traditional formulae have been found to exert obvious effects on insomnia, such as Ji...
This study aims to explore the effect and mechanism of Jiao-tai-wan (JTW) on systemic and tissue-specific inflammation and insulin resistance in obesity-resistant (OR) rats with chronic partial sleep deprivation (PSD). OR rats with PSD were orally given JTW and Estazolam for 4 weeks. The amount of food intake and metabolic parameters such as body w...
Objective
To explore the effect and mechanism of Jiaotai Pill (交泰丸, JTW) on intestinal mucosal damage in rats with chronic partial sleep deprivation (PSD). Methods
Obesity resistant (OR) rats were selected, and underwent 4 h PSD by being exposed to environmental noise for 4 weeks. During the whole PSD period, JTW and estazolam were orally given to...
Citations
... Huang et al. reported that TXNRD1 knockout could significantly inhibit the proliferation and metastasis of hepatocellular carcinoma cells both in vivo and in vitro, while its overexpression had the opposite effect. Furthermore, TXNRD1 dampened the interaction between Trx1 and PTEN, accelerating the degradation of PTEN, which activated Akt/mTOR signaling and target genes, ultimately promoting migration and metastasis of hepatoma cell [47]. ...
... Gong et al. [19] performed a simple correlation analysis of viral shedding and antibody level under a retrospective cohort of 564 participants, but found that viral shedding duration was not significantly correlated with antibody concentration. However, in this correlation analysis, the dynamic change of antibody level was not considered for exploring its influence on the duration of virus shedding. ...
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... Coptis chinensis is one of the earliest recognized and most valuable medicinal plants in China; it has been used to treat diabetes for over two thousand years. It has been shown to have various effects, such as lowering blood glucose, improving insulin secretion, and modulating intestinal microbiota [27][28][29][30]. Recent clinical studies have confirmed the efficacy of berberine (the main component of Coptis chinensis) for diabetes as it can induce insulin secretion in a glucose-dependent manner, thus avoiding the risk of hypoglycemia [31][32][33]. ...
... The PI3K/Akt signaling pathway regulates neuronal cell proliferation, apoptosis, and differentiation in the brain, thereby inhibiting cell hypermobility (Xing et al., 2020) and participating in the repair of neurons and recovery of cognitive functions after sleep deprivation; this is achieved by regulating apoptosis and inflammation (Zeng et al., 2019;Wan et al., 2022). Inhibition of PI3K and Akt protein expression triggers severe sleep deprivation in rats, affecting their circadian rhythms (Huang et al., 2018), which in turn damages neuronal cells and affects learning memory functions. (Li et al., 2022). ...
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... In brain tissue, JTP increases c-aminobutyric acid levels and modulates the hypothalamic monoaminergic system and organic cation transporters [9]. In the intestine, JTP protects gut mucosa, regulates rhythm proteins [10], and decreases levels of lipopolysaccharides and infammatory factors [7]. Te efects of JTP on the brain-gut axis deserve further investigation. ...
