Weijun Tang's scientific contributions
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It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
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Publication (1)
Activation of α-7 nicotinic acetylcholine receptor (α7nAChR) receptor might induce cardiac inflammation, cardiac remodeling, and dysfunction. In this regard, this study aims to clarify the role and mechanism of α7nAChR in the process of cardiac inflammation and damage. Normal male C57BL/6J and NLRP3-knockout mice were used to evaluate the effect of...
Citations
... Upon activation, NLRP3 recruits ASC and caspase-1 to form the inflammasome complex, which leads to the activation of caspase-1 and the induction of pyroptosis [48]. Furthermore, activated caspase-1 cleaves pro-inflammatory cytokines, such as IL-1β and IL-18, which are released from the dying cell and contribute to the inflammatory response [49]. Not surprisingly, LPS treatment up-regulated the protein levels of caspase-1, ASC and NLRP3, and the number of PI-positive cells increased, suggesting that pyroptosis and apoptosis were activated. ...
