Wei Zhao's research while affiliated with Sichuan Agricultural University and other places
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Publications (15)
Background
Recent studies have characterized that microRNA (miRNA) is a suitable candidate for the study of bleomycin/LPS-induced pulmonary fibrosis, but the knowledge on miRNA in bacteria-induced pulmonary fibrosis (BIPF) is limited. Forest musk deer ( Moschus berezovskii , FMD) is an important endangered species that has been seriously affected b...
Increasing reports have indicated that specific strains of probiotic Bacillus have the potential to prevent diseases. The purpose of this study was to explore the effects of three Bacillus strains (Bacillus subtilis BSWJ2017001, Bacillus pumilus BSWJ2017002, and B. subtilis BSWJ2017003) mixture dietary supplementation on rex rabbits infected with e...
The multi-functional properties of lactic acid bacteria (LAB) on host health have been a popular research topic. The aim of present study was to assess the multi-functional potential of five LAB strains isolated from giant panda. In this study, we analyzed five giant panda LAB strains (Weissella confuse WJ202003 (W3), WJ202009 (W9), WJ202021 (W21),...
Neurotropic viruses have neural-invasive and neurovirulent properties to damage the central nervous system (CNS), leading to humans’ fatal symptoms. Neurotropic viruses comprise a lot of viruses, such as Zika virus (ZIKV), herpes simplex virus (HSV), rabies virus (RABV), and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Effecti...
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The screening of reference genes for real-time quantitative PCR (qPCR) in forest musk deer (FMD) tissue is of great significance to the basic research on FMD. However, there are few reports on the stability analysis of FMD reference genes so far. In this study, We used qPCR to detect the expression levels of 11 reference gene candidates (18S rRNA,...
Forest musk deer ( Moschus berezovskii ) is an endangered, protected species in China. Intestinal coccidiosis is a significant problem for captive forest musk deer. However, there are few reports on the prevalence and molecular characteristics of Eimeria sp. in forest musk deer. We sought to investigate the prevalence of Eimeria sp. in forest musk...
Background
The forest musk deer (FMD, Moschus berezovskii) is an threatened species in China. Bacterial pneumonia was found to seriously restrict the development of FMD captive breeding. Historical evidence has demonstrated the relationship between immune system and intestinal Lactobacillus in FMD.Objective
We sought to elucidate the differences in...
Background: Forest musk deer (Moschus berezovskii) is a national first-level protected and endangered wild animals in China. The intestinal coccidiosis of captive forest musk deer is one of the most important diseases. However, few studies have been conducted to quantify Eimeria sp. infection and to identify its molecules. Thus, the objective of th...
Numerous studies have shown that probiotic Bacillus could promote growth and enhance anti-disease ability in animal. In present study, the mixture of three Bacillus strains, which were isolated from rex rabbits and showed high cellulose, protease, and amylase activities, was added into the diet for investigating its effects on young and weaning rex...
Forest musk deer (FMD; Moschus berezovskii) immunoglobulin G efficiently bound to streptococcal G protein (SPG) and weakly bound to staphylococcal A protein. The results suggested that horseradish peroxidase–conjugated SPG could be chosen as an enzyme-labeled antibody substitute and laid a foundation for immunologic research in FMD disease.
LysR-type transcriptional regulators are involved in the regulation of numerous cellular metabolic processes in Klebsiella pneumoniae, leading to severe infection. Earlier, we found a novel LysR family gene, named kp05372, in a strain of K. pneumoniae (designated GPKP) isolated from forest musk deer. To study the function of this gene in relation t...
Streptococcus spp. cause a wide range of diseases in animals and humans. A Streptococcus strain (FMD1) was isolated from forest musk deer lung. To identify the bacterium at the species level and investigate its pathogenicity, whole genome sequencing and experimental infections of mice were performed. The genome had 97.63% average nucleotide identit...
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Probiotics are intended to provide health benefits when consumed, generally by improving or restoring the gut flora. The health problems of forest musk deer (FMD, Moschus berezovskii), a threatened species currently under conservation, restrict the development of captive musk deer. This study was conducted with the aim of analyzing the effects of f...
Klebsiella pneumoniae is an important pathogen commonly associated with opportunistic infections. In this study, lung pathogenic K. pneumoniae (LPKP) was isolated and identified from suppurative pneumoniae in forest musk deer by conventional methods and by 16S ribosomal RNA sequence analysis. Median lethal dose and histopathologic analysis were use...
Pneumonia is one of the major diseases of forest musk deer (FMD) that affects the survival of musk deer breeding farms. Lung pathogenic Escherichia coli (LPEC) strains were found to be one of the principal bacterial pathogens, and O78 was found to be the dominant serotype and the most poisonous, thus it was selected as further study. Here we have f...
Citations
... This is a membrane proteoglycan and TGFβ regulator that often functions as a co-receptor with the ability of modulate TGFβ receptors I and II, and its pro-fibrotic signaling cascade. Moreover, miRNA let-7f downregulates PI3K signaling pathway in fibrosis via targeting of PIK3 [45]. Regarding miRNAs with high abundance and 1.3-1.4 ...
... Probiotic bacteria of the genus Bacillus are of great interest to researchers. Beneficial bacilli play a key role in intestinal homeostasis, promoting the growth of other beneficial bacteria and inhibiting the growth of pathogens and pathobionts, contribute to the proper development, maturation and functioning of the immune system, strengthening the epithelial barrier, normalizing digestion and metabolism, etc. [1,2,3,4]. The former notion of Bacillus as "transient" members of the gut microbiome is incorrect as they are most likely intestinal colonizers [3]. ...
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... The pH of L. plantarum 5-1 pH changed rapidly, reaching a final pH of 3.31 at 24 h. Moreover, the acid-production rate of L. plantarum 5-1 was 10% higher than that reported for L. plantarum G83 [32]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1182021783158791-1658827362194_Q64/Yang-Pu-10.jpg)
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... Both Ag and Au NPs have promising antiviral properties, particularly against enveloped DNA/RNA viruses. A recent study on COVID-19 viral disease explains about the neurotropism property demonstrating the application of NPs by inhibiting replication by cellular transcytosis blockade when given in the form of encapuslted particles (Ren et al., 2021). ...
... Various studies have validated the stability and suitability of these genes as reference genes under diverse experimental conditions, in livestock species like sheep, goat, and cattle, across different tissues and developmental stages. For example, ACTB has been identified as the most stable reference gene in tissues like muscle, liver, and spleen of cattle and sheep [16] and liver of forest musk deer [18]. There are many studies in goats where ACTB has been reported to have the most stable expression in diverse tissues such as rumen [19], perirenal adipose [20], stomach, small intestine and ovary [7]. ...
... An imbalance in intestinal microbiota is often accompanied by a reduction in microbiota diversity. The decreased diversity and richness of animal gut microbiota can increase the probability of diseases in the affected animals [11,12]. While gut microbiota is influenced by a variety of factors, food is the most direct factor affecting the diversity of animal intestinal microbiota [13]. ...
... The effects of LAB on the growth performance, health status and meat quality of rabbits have been widely studied [11][12][13][14]. Most researchers have observed that the addition of LAB to rabbit diets can improve feed conversion and productivity, enhance host immune function and reduce morbidity and mortality. ...
... Moreover, FMD is the major species of musk deer that can be reared artificially in special farms under the support of the Chinese government, which contributes to the growth of the population, reduction of poaching behaviors, and better utilization of FMD resources (9,10). The increase in the population of FMD is also limited by some fatal diseases including pneumonia (11)(12)(13). Pneumonia can be caused by multiple pathogens including bacteria (14)(15)(16). However, previous research on pneumonia mainly focused on the isolation, identification, and genome analysis of pathogens in FMD (12,17,18). ...
... Musk deer is one of the first-class protected and endangered animals in China [1]. In captive environment, intestinal disease is the main disease that threatens musk deer breeding [2,3]. ...
... PF is a fatal disease of the respiratory system that affects the health and survival of animals accompanied by an overproliferation of fibroblasts and an inflammatory reaction (13)(14)(15). Bacterial pneumonia, especially PF, severely affected the survival of FMD in captivity (16). There are many causes for the formation of PF, among which infectious bacterial are the important causes (17). ...
