Wei Zhang's research while affiliated with Zhengzhou University and other places
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Publications (806)
Yeast culture (YC) plays a significant role in enhancing the performance and health of poultry breeding. This study investigated the impact of different YC supplementation concentrations (basal diet with 1.0 g/kg and 2.0 g/kg of YC, YC1.0, and YC2.0) on egg production performance, egg quality, antioxidant properties, intestinal mucosal structure, a...
Ratiometric fluorescence and colorimetric strategies for detecting activity of butyrylcholinesterase (BChE) in human serum were developed by using g-C3N4 nanosheets, silver ion (Ag⁺) and o-phenylenediamine (OPD) as chromogenic agents. The oxidation-reduction reaction of OPD and Ag⁺ generates 2,3-diaminophenazine (oxOPD). Under exciation at 370 nm,...
Magnonics is a research field that has gained an increasing interest in both the fundamental and applied sciences in recent years. This field aims to explore and functionalize collective spin excitations in magnetically ordered materials for modern information technologies, sensing applications and advanced computational schemes. Spin waves, also k...
Uncovering the trade-offs and synergy relationship of multiple ecosystem services (ESs) is important for scientific ecosystem management and the improvement of ecological service functions. In this study, we investigated the spatiotemporal changes of four typical ES types (i.e., water yield (WY), carbon storage (CS), soil conservation (SC), and hab...
Background
Resistance to immune checkpoint inhibitors (ICIs) represents a major unmet medical need in non-small cell lung cancer (NSCLC) patients. Vascular endothelial growth factor (VEGF) inhibition may reverse a suppressive microenvironment and recover sensitivity to subsequent ICIs.
Methods
This phase Ib/IIa, single-arm study, comprised dose-fi...
Background:
To date, there is no effective treatment for Alzheimer's disease (AD), a progressive neurodegenerative disorder that is increasing in prevalence worldwide. The objective of this review was to summarize the core targets and signaling pathways involved in acupuncture treatment for AD.
Methods:
We reviewed numerous signaling pathways, i...
Dry eye disease (DED) is a major global eye disease leading to severe eye discomfort and even vision impairment. The incidence of DED has been gradually increasing with the high frequency of use of electronic devices. It has been demonstrated that celastrol (Cel) has excellent therapeutic efficacy in ocular disorders. However, the poor water solubi...
e15028
Background: Multi-cancer early detection (MCED) tests have emerged as promising tools for reducing cancer-related healthcare costs and mortality. As metabolome is closely linked to the phenotype of bio-individual, metabolomics analysis enables the high throughput investigating of the pathophysiological conditions. Based on metabolomics and m...
Background
The description of long-term trends in the cancer burden among children aged zero to nine years from 1990 to 2019 reveals significant changes in children’s health. It helps in resource allocation and health policy planning. We analysed data on the incidence, mortality, and disability-adjusted life years (DALYs) by sex and age group in ch...
Recently, the study of endoplasmic reticulum stress (ERS) and liver disease has attracted much attention, but bibliometric analysis on this field is scarce. Therefore, to address this gap, we conducted a bibliometric analysis to explore the research status, hotspots, and trends in this field. We searched the Web of Science Core Collection database...
Background
Gender disparity is pervasive in academic medicine. This study aimed to assess the disparity between men and women with regard to first and senior author positions in primary studies on liver cancer over the last two decades.
Methods
We conducted a review of articles published in high-impact factor journals of the field of Gastroenterol...
Objective
Most studies investigated the relationship between COVID-19 and Guillain-Barré syndrome (GBS) by comparing the incidence of GBS before and during the pandemic of COVID-19. However, the findings were inconsistent, probably owing to varying degrees of the lockdown policy. The quarantine requirements and travel restrictions in China were lif...
AIM: To evaluate dry eye disease (DED) symptomatology and mental health status in different COVID-19 patients. METHODS: A cross-sectional observational design was used. Totally 123 eligible adults (46.34% of men, age range, 18-59y) with COVID-19 included in the study from August to November, 2022. Ocular Surface Disease Index (OSDI), Five-item Dry...
Introduction
China has experienced unprecedented transformations unseen in a century and is gradually progressing toward an emerging superpower. The epidemiological trends of digestive diseases in the United States (the US) have significant prescient effects on China.
Methods
We extracted data on 18 digestive diseases from the Global Burden of Dis...
Introduction
Although LncRNA JPX has been linked to a number of malignancies, it is yet unknown how it relates to endometrial carcinoma (EC). Investigating the expression, functional activities, and underlying molecular processes of lncRNA JPX in EC was the goal of this work.
Methods
RT-qPCR was used to examine the differences in lncRNA/microRNA (...
Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing the development of dry eye disease (DED). The currently available eye drops for DED treatment are palliative, short-lived and frequently administered due to the short precorneal residence time. Here, we...
The chiral induced spin selectivity (CISS) effect, in which the structural chirality of a material determines the preference for the transmission of electrons with one spin orientation over that of the other, is emerging as a design principle for creating next-generation spintronic devices. CISS implies that the spin preference of chiral structures...
The majority of advanced breast cancers exhibit strong aggressiveness, heterogeneity, and drug resistance, and currently, the lack of effective treatment strategies is one of the main challenges that cancer research must face. Therefore, developing a feasible preclinical model to explore tailored treatments for refractory breast cancer is urgently...
Background
This study aimed to explore the expression level and transcriptional regulation mechanism of Extra Spindle Pole Bodies Like 1 (ESPL1) in bladder cancer (BC).
Methods
A multicentre database of samples (n = 1391) was assayed for ESPL1 mRNA expression in BC and validated at the protein level by immunohistochemical (IHC) staining of in-hous...
Background
This study aimed to explore the expression, molecular mechanism and its biological function of potassium two pore domain channel subfamily K member 1 (KCNK1) in bladder cancer (BC).
Methods
We integrated large numbers of external samples (n = 1486) to assess KCNK1 mRNA expression levels and collected in-house samples (n = 245) for immun...
PCSK9 inhibitors (Proprotein convertase subtilisin-kexin9 inhibitors) not only have a good lipid-lowering effect but also have the effects of improving cardiovascular outcome, anti-inflammation, reducing oxidative stress and improving vascular endothelium. In recent years, the continuous research and development of PCSK9 inhibitors have provided ne...
In aqueous aluminum‐ion batteries(AAIBs), the insertion/extraction chemistry of Al3+ often leads to poor kinetics, whereas the rapid diffusion kinetics of hydrated hydrogen ions (H3O+) may offer the solution. However, the presence of considerable Al3+ in the electrolyte hinders the insertion reaction of H3O+. Herein, we report how oxygen‐deficient...
Background
Brain tumors are one of the leading causes of epilepsy, and brain tumor‐related epilepsy (BTRE) is recognized as the major cause of intractable epilepsy, resulting in huge treatment cost and burden to patients, their families, and society. Although optimal treatment regimens are available, the majority of patients with BTRE show poor res...
Background
Osteoarthritis and lipid metabolism are strongly associated, although the precise targets and regulatory mechanisms are unknown.
Methods
Osteoarthritis gene expression profiles were acquired from the GEO database, while lipid metabolism-related genes (LMRGs) were sourced from the MigSB database. An intersection was conducted between the...
Background
Combining immune checkpoint inhibitors (ICIs) with chemotherapy has become a standard treatment for patients with non-small cell lung cancer (NSCLC) lacking driver gene mutations. Reliable biomarkers are essential for predicting treatment outcomes. Emerging evidence from various cancers suggests that early assessment of serum metabolites...
Background There has not been a definite study on the relationship between serum lipid and small cell lung cancer (SCLC) patients’ response to programed death-ligand 1 (PD-L1) inhibitor.
Objective The aim of this study was to explore the association between serum lipids levels and SCLC patients’ response to PD-L1 inhibitor as first-line treatment....
Background
Studies have shown that mitochondrial function and macrophages may play a role in the development of idiopathic pulmonary fibrosis (IPF). However, the understanding of the interactions and specific mechanisms between mitochondrial function and macrophages in pulmonary fibrosis is still very limited.
Methods
To construct a prognostic mod...
Background
Acute pancreatitis is easily confused with abdominal pain symptoms, and it could lead to serious complications for pregnant women and fetus, the mortality was as high as 3.3% and 11.6–18.7%, respectively. However, there is still lack of sensitive laboratory markers for early diagnosis of APIP and authoritative guidelines to guide treatme...
Aims
Early identification and intervention of the frailty of the elderly will help lighten the burden of social medical care and improve the quality of life of the elderly. Therefore, we used machine learning (ML) algorithm to develop models to predict frailty risk in the elderly.
Design
A prospective cohort study.
Methods
We collected data on 69...
Currently, public health is seriously threatened by the massive concentrations of emerging contaminants. Treating emerging contaminants in water using effective methods has become a major challenge worldwide. Photocatalytic technology, as an eco-friendly technology, has been recognized as an effective means of removing contaminants from water. Amon...
Nanozymes have demonstrated significant potential in combating malignant tumor proliferation through catalytic therapy. However, the therapeutic effect is often limited by insufficient catalytic performance. In this study, we propose the utilization of strain engineering in metallenes to fully expose the active regions due to their ultrathin nature...
Cadmium (Cd) and lead (Pb) are heavy metals prevalent in the environment and feed, and they reduce production performance of domestic animals, as well as they result in residue in animal tissues. The kidney is the target tissue for Cd and Pb. And the kidney is crucial for the reabsorption of calcium (Ca), which consequently influences bone strength...
Background
Irinotecan is widely used in the treatment of various solid tumors, but the adverse effects from it, especially diarrhea, limit its use. Several clinical trials of prophylactic treatment of irinotecan-induced diarrhea (IID) have been ongoing, and some of the data are controversial. This encouraged us to conduct a meta-analysis of the eff...
Background
We assessed the potential role of serial circulating tumor DNA (ctDNA) as a biomarker to monitor treatment response to primary systemic therapy (PST) in breast cancer and evaluated the predictive value of ctDNA to further identify patients with residual disease.
Methods
We prospectively enrolled 208 plasma samples collected at three tim...
Mental disorders are the leading contributors to the globally nonfatal burden of disease. This study was aimed to estimate the burden of mental disorders in Asian countries. Based on GBD 2019, the prevalence and disability-adjusted life of years (DALYs) rates with 95% uncertainty intervals (UI) were estimated in Asian countries. Predictions for the...
The mass transfer behavior in a hollow fiber membrane module of membrane-based artificial organs (such as artificial liver or artificial kidney) were studied by numerical simulation. A new computational fluid dynamics (CFD) method coupled with K-K equation and the tortuous capillary pore diffusion model (TCPDM) was proposed for the simulations. The...
Background
Malignant mesothelioma is a type of infrequent tumor that is substantially related to asbestos exposure and has a terrible prognosis. We tried to produce a fibroblast differentiation-related gene set for creating a novel classification and prognostic prediction model of MESO.
Method
Three databases, including NCBI-GEO, TCGA, and MET-500...
Objective
This study sought to explore the clinical value of matrix metalloproteinases 12 (MMP12) in multiple cancers, including lung adenocarcinoma (LUAD).
Methods
Using >10,000 samples, this retrospective study demonstrated the first pan-cancer analysis of MMP12. The expression of MMP12 between cancer groups and their control groups was analyzed...
Dry eye disease (DED) is a major ocular pathology worldwide, causing serious ocular discomfort and even visual impairment. The incidence of DED is gradually increasing with the high-frequency use of electronic products. Although inflammation is core cause of the DED vicious cycle, reactive oxygen species (ROS) play a pivotal role in the vicious cyc...
In light of the situation and the characteristics of Omicron, the country has continuously optimized the rules for the prevention and control of COVID-19. The global epidemic is still spreading, and new cases of infection continue to emerge in China. To facilitate the infected person to estimate the course of virus infection, a prediction model for...
Layered double hydroxide (LDH) nanostructures are commonly used to study the interfacial effects of Pt‐based catalysts in CO oxidation. However, the specific role and detailed intermediates involved in CO oxidation remain unclear. Density functional theory (DFT) predicted that NiFe LDH loaded with single Pt atoms would exhibit satisfactory CO oxida...
The integration of real‐time monitoring and on‐demand treatment has substantial potential to accelerate wound healing processes. In this context, versatile bilayer microneedles (MNs) and a triboelectric nanogenerator (TENG) are developed as a theranostic platform for efficient wound management. This platform provides benefits including controlling...
Investigating spin dynamics in electrocatalysis is crucial for the rational design of magnetically heterogeneous catalysts. Utilizing spin‐polarized density functional theory calculation, herein, the spin dynamic of diatomic Co₂‐supported γ‐graphyne (Co2‐GY) catalysts during the process of CO electroreduction (eCORR) is identified, focusing on the...
Purpose
The assessment of tear film and ocular surface conditions in patients with acquired immunodeficiency syndrome (AIDS) has been poorly studied thus far. We aim to assess tear film parameters, ocular surface characteristics, and dry eye disease (DED) symptoms of patients with AIDS who did not undergo highly active antiretroviral treatment (HAA...
Objectives
The prevalence of non-alcoholic fatty liver disease (NAFLD) in China has significantly increased due to changing lifestyles and rising obesity rates. Effective self-management behaviours are crucial for reversing NAFLD. This study aimed to assess the current self-management status and the influencing factors among the Chinese NAFLD popul...
Objectives Through searching and summarizing the medication-related disputes and claims in Beijing, we found the factors that were most likely to cause disputes during the medication process. These provided a basis for further exploration of medication-related dispute prevention and control measures. Methods We took all medication-related dispute a...
Considering the fluctuation of predicted output power of new energy units such as wind power, a strategy to strengthen the dispatching optimization of new energy distribution network is proposed. Taking the constraints such as operation cost, voltage deviation and network loss of distribution network as a reference, we provide the description of wi...
![The diagram of DRUNet [41].](publication/377865181/figure/fig3/AS:11431281231829001@1711541041028/The-diagram-of-DRUNet-41_Q320.jpg)
![The diagram of USRNet [18].](publication/377865181/figure/fig4/AS:11431281231788788@1711541041249/The-diagram-of-USRNet-18_Q320.jpg)
Joint super-resolution and pansharpening (JSP) brings new insight into the spatial improvement of multispectral images. How to efficiently balance the spatial and spectral qualities in JSP is important for deep learning-based approaches. To address this problem, we propose a unified interpretable deep network for JSP, named UIJSP-Net. First, we for...
Timely acquisition of soil moisture content (SMC) in the root zone of field crops is crucial for achieving precise irrigation. In this study, high-spectral technology was employed to collect both SMC data at different soil depths during the bolting stage of winter oilseed rape (Brassica napus L.) and corresponding hyperspectral data through two con...
With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects as drug delivery vehicles. However, they exhibit certain limitations, including low biocompatibility, poor physiological stability, rapid clearance from the body, and nonspecific targeting, which have hampered their clinical application. Therefore, the developmen...
Background
Radiosensitivity remains an important factor affecting the clinical outcome of radiotherapy for non-small cell lung cancer (NSCLC). Liver kinase B1 (LKB1) as a tumor suppressor, is one of the most commonly mutated genes in NSCLC. However, the role of LKB1 on radiosensitivity and the possible mechanism have not been elucidated in the NSCL...
To explore the mechanism of electroacupuncture (EA) in promoting recovery of the facial function with the involvement of autophagy, glial cell line-derived neurotrophic factor (GDNF), and phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling pathway.
Seventy-two male Sprague-Dawley rats were randomly allocated into the...
While dysbiosis within the intestinal ecosystem has been associated with functional constipation (FC), the mechanisms underlying the interactions between FC and the microbiome remain poorly elucidated. Recent investigations suggested that host microRNAs (miRNAs) can modulate bacterial growth and influence the composition of the gut microbiome. To e...
Reducing the overapplication of nitrogen fertilizers to potatoes (Solanum tuberosum L.) can reduce production costs and their impact on the environment. One approach to produce these impacts is to reduce overapplications of fertilizers by using the nitrogen nutrition index (NNI = plant nitrogen concentration/critical nitrogen concentration) as a ba...
In 2019, we conducted a cross-sectional study for polio virus seroprevalence in Guangdong province, China. We assessed the positivity rates of poliomyelitis NA and GMT in serum across various demographic groups, and the current findings were compared with pre-switch data from 2014. Using multistage random sampling method, four counties/districts we...
Background
Lung cancer (LC) is one of the most devastating diseases worldwide, there is growing studies confirm the role of impaired lung function in LC susceptibility. Moreover, gut microbiota dysbiosis is associated with LC severity. Whether alterations in gut microbiota and metabolites are associated with long-term lung dysfunction in LC patient...
Blastoid or pleomorphic mantle cell lymphoma (B/P-MCL) is characterized by high invasiveness and unfavorable outcomes, which is still a challenge for treating MCL. This retrospective study was performed to comprehensively analyze the clinical, genomic characteristics and treatment options of patients with B/PMCL from multicenter in China. Data were...
A novel environment-friendly oxygen-vacancy-rich Cu-doped zeolite decorated with Cu ⁰ (Cu ⁰ @CuZ) was fabricated to achieve the high-efficiency removal of refractory organic pollutants in a photo-Fenton-like reaction.
Addressing the limitations arising from the consistent catalytic behavior observed for various intermediates during the electrochemical carbon dioxide reduction reaction (CO2RR) poses a significant challenge in the optimization of catalytic activity. In this study, we aimed to address this challenge by constructing an asymmetric coordination Fe sin...
Early detection of hepatocellular carcinoma (HCC) can greatly improve the survival rate of patients. We aimed to develop a novel marker panel based on cell-free DNA (cfDNA) methylation for the detection of HCC. The differentially methylated CpG sites (DMCs) specific for HCC blood diagnosis were selected from The Cancer Genome Atlas (TCGA) and Gene...
Emerging evidence suggests that the gastrointestinal tract plays a crucial role in the pathophysiology of sepsis, a leading cause of mortality among patients admitted to the intensive care unit (ICU). Malvidin, belonging to the flavonoid family of compounds, exhibits a range of capabilities including anti-inflammatory and antioxidant properties. St...
Addressing the limitations arising from the consistent catalytic behavior observed for various intermediates during the electrochemical carbon dioxide reduction reaction (CO2RR) poses a significant challenge in the optimization of catalytic activity. In this study, we aimed to address this challenge by constructing an asymmetric coordination Fe sin...
Background
Acyl-CoA-binding domain-containing 3 (ACBD3) is a multifunctional protein, that plays essential roles in cellular signaling and membrane domain organization. Although the precise roles of ACBD3 in various cancers remain unclear. Thus, we aimed to determine the diverse roles of ACBD3 in pan-cancers.
Methods
Relevant clinical and RNA-sequ...
An excellent single-atomic photocatalyst, Ti@C 4 N 3 , is theoretically found to effectively convert CO 2 to C 2 H 6 by density functional theory (DFT) calculations and non-adiabatic molecular dynamics (NAMD) simulations. The Ti@C 4 N 3 photocatalyst has remarkable stability both thermally, chemically, and mechanically. Electronically, it has stron...
Citations
... Chlorophyll is one of the most important pigments in plants; in the process of photosynthesis, chlorophyll plays a crucial role in facilitating energy conversion and sustaining the growth and development of plants. Furthermore, it acts as a protective and regulatory agent in maintaining plant health, thereby aiding in plant adaptation to external environmental conditions [4]. Romina et al. [5] used different kinds of chlorophyll instruments to determine the nitrogen content in crops by measuring the chlorophyll content of sweet peppers. ...
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... Cadmium can enter the body of animals and humans through the food chain, accumulate for extended periods and ultimately cause damage to multiple organs and tissues, owing to it has long biological half-life (nearly 10−30 yr) and low clearance rate . Several studies have illustrated that Cd exposure has been linked to kidney disease, osteoporosis, bone fractures, neurodegenerative disease, atherosclerosis and cardiovascular disease, pulmonary disease, hyperkeratosis, and acanthosis in the skin (Tucovic et al., 2018;Ma et al., 2022;Zhao et al., 2024). Among them, nephrotoxicity is one of its foremost toxicities, mainly by inducing oxidative stress. ...
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... Micromagnetics [1,2] is an effective tool for studying magnetic structures and phenomena at the micrometer scale. With the fast development of high-performance computation, micromagnetic simulations have been applied in various technological applications, such as magnetic recording media, magnonics [3,4], magnetic sensors, and spintronic devices [5][6][7]. ...
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... The disability-adjusted life-years (DALY) of mental disorders in the Middle East and North African countries are estimated to be 1990.5 per 100,000 people in 2019 11 . In Asia, the trend of mental disorders increased from 377.9 million cases in 1990 to 555.4 million cases in 2019 12 . In 2020, the prevalence of mental disorders among the general population in Iran was 29.7% 13 . ...
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... To observe the therapeutic effect of Cel NMs on DED in mice, the commonly used topical 0.2% BAC was used as a drug to induce acute corneal epithelial defect and DED caused by ROS overproduction [41]. 0.05% CSA, a clinically approved DED treatment, was used as a positive control. ...
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... Carbon black-coated nylon, silver-plated nylon, and elastic spandex yarns, which exhibited flexibility and heating performance, provided hyperthermia to injured joints in response to joint motion measured in a spiral twist structure. An integrated bilayer microneedles dressing and TENGs offer an efficient therapeutic platform for wound management [212]. One layer serves as an electrochemical sensor, while the other is antibiotic-coated for drug delivery. ...
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... Each criterion was formulated as a question and scored as "yes" or "no". [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], Bradykinesi a 46 (33.3) [30], [31], [33], [34], [37], [39], [40], [41], [43], [46], [46], [47], [48], [49], [50], [51], [52], [55], [56], [59], [60], [62], [63], [64], [65], [65], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86] Postural instability 11 (8) [39], [59], [76], [87], [88], [89], [90], [91] Gait disturbances 80 (58) [56], [61], [63], [84], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [100], [101], [102], [103], [104], [105], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [137], [138], [138], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157] Dyskinesia 36 (25.4) [31], [32], [33], [35], [40], [41], [43], [50], [50], [51], [55], [62], [64], [65], [67], [68], [68], [69], [72], [73], [74], [77], [79], [81], [83], [85], [86], [149], [158], [159], [160], [161] Table 5. PD motor features covered by the included studies. Note that multiple features covered per study are possible. ...
... This method is not only time-consuming and labor-intensive, but also yields delayed and unstable results, greatly limiting the accuracy and timeliness of agricultural decision making [10]. In modern precision agriculture, efficient and non-destructive monitoring of crop growth status is vital [11]. Remote sensing technology, as a novel detection approach, enables the real-time acquisition of various spectral information of land cover on a large scale and has been widely applied in modern agricultural management [12]. ...
... Biomimetic nano-drug delivery system (BNDDS) mainly consists of core particles with drug-loaded nanostructures and biomimetic outer membranes with biological activity. 15 In recent years, a novel approach utilizing biomimetic material coatings has revolutionized nanoparticle functionalization. 16 This innovative technique involves the transfer of plasma membranes from native cells onto synthetic nanoparticles. ...
... Several studies have shown that combining Cell-free DNA (cfDNA) methylation-specific highthroughput or MSP testing with serology enhances the accuracy of serological assays of alpha-fetoprotein (AFP) alone during early screening for HCC. 40 In targeted therapy of HCC, DNA methyltransferases (DNMT) and DNA demethylases (ten-eleven translocation, TET) in methylation modification may play an important role. In cancer stem-like cells (CSCs), coordinated activation of DNMT3a and TET2 triggers and maintains drug resistance, which would be a therapeutic target for refractory HCC. ...
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