Véronique Senty-Ségault's research while affiliated with University of Lorraine and other places

... The FBL homolog in yeast, Nop1p, is also localized in the nucleolus and is involved in 18S rRNA processing and maturation. 26 Serum from patients with scleroderma, an autoimmune disease, often contains high levels of antibodies against FBL. 27 The exact mechanism by which FBL affects these processes has not been discovered, but some experimental data suggest that upregulation or downregulation of FBL can alter ribosomal structure and thus the relative translation efficiency of various mRNAs, potential contributing to the regulation of cell proliferation, cancer progression, and aging. ...

... rRNA maturation involves stepwise spacer cleavage from the polycistronic 45S pre-rRNA, which relies on extensive interactions between pre-rRNA and U3 RNA 37 . Several U3 binding sites on the 5′ external transcribed spacer (ETS) have been identified in bacteria and lower eukaryotes biochemically [38][39][40][41] , but the landscape of U3-pre-rRNA interactions within mammalian cells and how these interactions influence the 5′ ETS structure are unclear. The 5′ ETS of mammalian pre-rRNA harbors three closely located cleavage sites, namely A′, A0 and 1 (Fig. 4d) 37 . ...

... Описаны два основных класса мякРНК, различающиеся по содержащимся в них мотивам последовательностей нуклеотидов, структуре, взаимодействующим с ними белкам и, как следствие, химической модификации, которую они катализируют [119]. Малые ядрышковые РНК с C / D-боксами варьируются по длине от 70 до 130 нуклеотидов и характеризуются наличием сайтов C (RUGAUGA) и D (CUGA), обнаруженных около 5'-и 3'-концов молекулы и взаимодействующих посредством неканонического спаривания оснований, образующего кинк-поворот [120][121][122]. Дополнительные мотивы, C' и D', с такими же консенсусными последовательностями, как блоки C и D, соответственно, но часто менее консервативные, обнаруживаются в середине молекулы [118,122]. ...

... Our EMSA and SPR measurements show that the helical domain of g5Rp can bind with ssRNA with equally high affinity as the full-length protein. Six a-helices form a globin-fold-like helical domain, which is different from the traditional RNA binding domain that prefers to adopt the alpha/beta topologies (42)(43)(44)(45). According to the g5Rp structure, the surface electrostatic potential characteristics of the N terminus present a highly positively charged area on helix a5. ...

... This snoRNA is produced as individual transcription unit and is connected to the p53 pathway [88,89]. Although U3 includes C/D box-like motifs, it is not involved in 2 -O-Methylation of rRNA but rather is directing site-specific cleavage of rRNAs [90]. Moreover, the studies identified a robust snoRNA signature for both AITL and PTCL-NOS capable of classifying these patients depending on their outcome. ...