V. Jarlier's research while affiliated with Hôpital La Pitié Salpêtrière (Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix") and other places

... Nevertheless, the TB strains unsusceptible to first line drugs, mostly the multidrug-resistant TB (MDR TB) is a continuous grave problem. The high incidence of a second threat from TB is observed specially in the immune-compromised patients and is known as extensively drug-resistant TB (XDR TB) 6,7 . Due to the silent form of Mycobacterium tuberculosis strains, various current frontline therapeutics have become ineffective and more people are prone to be infected with (MDR-TB) strains every year 8 . ...

... Being associated with a positive impact on health outcomes and decision-making, MDT cancer conferences are standard of care in many countries. 4 There are examples of national consilia and the use of telemedicine in managing TB, [5][6][7] and the WHO and the European Respiratory Society (ERS) have offered an online-based consilium service for complicated TB. 8 Having a national TB consilia could be considered a pre-requisite for being on the right track to TB elimination. 9 MDTs have also been used for other complicated infections, such as fungal diseases. ...

... Consequently, the register data (mycobacterial species reported between 2016 and 2022) used to compare the coverage of the GenoType and FluoroType Mycobacteria assays may be biased. For example, in the workflow, M. chimaera was only suspected based on atypical M. intracellulare banding patterns in the GenoType Mycobacterium CM assay (21). This method may miss some M. chimaera isolates and underestimate the need for M. chimaera identification by the primary identification test (22). ...

... Also, M. bovis could be an airborne zoonotic pathogen causing pulmonary tuberculosis (7). In western Europe countries, most of M. bovis human tuberculosis cases are seen in migrants and are associated with travel to the country of origin (4,5,8,9). M. bovis tuberculosis is traced to animal sources, yet reporting of clinical signs and symptoms is often delayed (3). The observation of a woman affected by M. bovis tuberculosis who participated in a precisely dated religious practice involving sheep slaughtering provided an opportunity to shed light on these medical aspects. ...

... Introducing new drug regimens in drug-resistant (DR) tuberculosis patients influences the level of therapy-related adverse events dramatically and affects therapeutic effectiveness in this patient cohort [4,9,31]. At the same time, no recommendations regarding the use of antihepatotoxicity drugs in tuberculosis patients, including those with MDR-TB and XDR-TB, have been proposed [14,17,32]. ...

... Immunoassays such as Enzyme-linked immune-sorbent assay (ELISA) depend on the usage of antibodies, enzymes, and conjugates which are expensive and need lengthy incubation times and particular conditions for their storage [39][40][41][42][43][44][45]. Targeted molecular MRI gathers the benefits of high spatial resolution and contrast without the necessity for ionizing radiation making it a charming imaging method to study molecular processes [46]. ...

... In silico DNA-DNA hybridization revealed that the aligned nucleotide sequences from M. peregrinum isolates 131_1 and 138 share 98.28% and 98.27% identity with the human M. peregrinum isolate [3], respectively, 88.46% sequence identity with M. fortuitum subsp. fortuitum [28], 85.18% sequence identity with Mycobacteroides abscessus [29], 84.60% and 84.61% identity with M. mucogenicum [30], respectively, 84.50% sequence identity with Mycobacteroides chelonae [31], and 84.21% sequence identity with M. neoaurum [32]. An aligned sequence identity score of both isolates was 100%, suggesting that M. peregrinum exists in the farm soil and both isolates might possibly be the same origin. ...

... In comparison, COVID-19 killed about 1.8 million people during 2020. 11 Currently, the major global TB challenge for the scientific community is the fight against drug-resistant forms of the disease, 12,13 particularly multidrug-resistant TB [MDR-TB; defined as resistance to at least rifampicin (RIF) and isoniazid (INH)] and extensively drug-resistant TB (XDR-TB). The latter was reclassified by the WHO in January 2021 as being either pre-XDR-TB, meaning MDR-TB plus further resistance to any fluoroquinolone, or XDR-TB, now redefined as MDR-TB plus further resistance to "any fluoroquinolone and at least one additional Group A drug" (see section 2 for drug groupings). ...

... Botswana, Chile, Cuba, Czech Republic and Uruguay had all showed a very low prevalence of MDR-TB confirming that efficient TB control programmes prevents the occurrence and spread of MDR-TB. 4,[6][7][8][9][10][11] A third WHO/IUATLD global project on drug resistance surveillance in 77 countries/geographical sites was carried out in 1999-2002 12 representing 20% of the global total of new smear positive TB cases. It included 39 settings not previously included in the Global Project and reported trends for 46 sites. ...

... The strains were identified as Mycobacterium aquae, which is now considered a synonym of Mycobacterium gordonae. M. gordonae is regarded as a nonpathogen, though it is speculated that it may become a pathogen under certain circumstances [8]. In this country, Shimizu et al [4] found tuberculosis-like skin lesions of the bovine udder in two animals. ...