Uwe Walter's research while affiliated with University Medical Center Rostock and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (200)
Importance
According to the current American Heart Association/American Stroke Association guidelines, decompressive surgery is indicated in patients with cerebellar infarcts that demonstrate severe cerebellar swelling. However, there is no universal definition of swelling and/or infarct volume(s) available to support a decision for surgery.
Objec...
Background and purpose
In amyotrophic lateral sclerosis (ALS), phrenic nerve (PN) atrophy has been found, whereas there is controversy regarding vagus nerve (VN) atrophy. Here, we aimed to find out whether PN atrophy is related to respiratory function and 12‐month survival. Moreover, we investigated the relevance of VN and spinal accessory nerve (A...
BACKGROUND AND OBJECTIVES
Space-occupying cerebellar stroke (SOCS) when coupled with neurological deterioration represents a neurosurgical emergency. Although current evidence supports surgical intervention in such patients with SOCS and rapid neurological deterioration, the optimal surgical methods/techniques to be applied remain a matter of debat...
Background: Several individual predictors for outcomes in patients with cerebellar stroke (CS) have been previously identified. There is, however, no established clinical score for CS. Therefore, the aim of this study was to develop simple and accurate grading scales for patients with CS in an effort to better estimate mortality and outcomes.
Meth...
Muscle ultrasound (MUS) is increasingly used by neurologists, neuropediatricians, neurosurgeons, specialized radiologists and anaesthesiologists for the imaging-supported diagnosis of neuromuscular disorders. Especially, MUS is highly sensitive in detecting fasciculations in motor neuron diseases, and in revealing intensive care unit acquired weakn...
Intensive care unit-acquired weakness (ICUAW) is one of the most common neuromuscular complications in intensive care medicine. The clinical diagnosis and assessment of the severity using established diagnostic methods (e.g., clinical examination using the Medical Research Council Sum Score or electrophysiological examination) can be difficult or e...
Background:
Parkinson's disease (PD) is a major cause of disability. We aimed to assess the benefit of ultrasonography of the vagus nerve (VN) to compare between PD and healthy controls as well as to deliver reference values of nerve cross sectional area (CSA).
Materials and methods:
We performed a systematic search on Medline (PubMed), Scopus,...
Intensive care unit-acquired weakness (ICUAW) is one of the most common causes of muscle atrophy and functional disability in critically ill intensive care patients. Clinical examination, manual muscle strength testing and monitoring are frequently hampered by sedation, delirium and cognitive impairment. Many different attempts have been made to ev...
BACKGROUND Iron content is increased in the substantia nigra of persons with Parkinson's disease and may contribute to the pathophysiology of the disorder. Early research suggests that the iron chelator deferiprone can reduce nigrostriatal iron content in persons with Parkinson's disease, but its effects on disease progression are unclear. METHODS...
Background:
Iron content is increased in the substantia nigra of persons with Parkinson's disease and may contribute to the pathophysiology of the disorder. Early research suggests that the iron chelator deferiprone can reduce nigrostriatal iron content in persons with Parkinson's disease, but its effects on disease progression are unclear.
Metho...
Background:
Pancreatic ductal adenocarcinoma (PDAC) is a disease of the elderly mostly because its development from preneoplastic lesions depends on the accumulation of gene mutations and epigenetic alterations over time. How aging of non-cancerous tissues of the host affects tumor progression, however, remains largely unknown.
Methods:
We took...
Objectives
The pathogenesis of fibromyalgia syndrome (FMS) is unclear. Transcranial ultrasonography revealed anechoic alteration of midbrain raphe in depression and anxiety disorders, suggesting affection of the central serotonergic system. Here, we assessed midbrain raphe echogenicity in FMS.
Methods
Sixty-six patients underwent transcranial sono...
The most important predictors for outcomes after ischemic stroke, that is, for health deterioration and death, are chronological age and stroke severity; gender, genetics and lifestyle/environmental factors also play a role. Of all these, only the latter can be influenced after the event. Recurrent stroke may be prevented by antiaggregant/anticoagu...
Because of the insidious character and variations in presenting symptoms, Charcot–Marie–Tooth (CMT) disease is challenging to diagnose in children. Diagnosis is based on clinical and nerve conduction studies, as well as genetic examination. Therefore, competent nerve imaging techniques and non-invasive alternatives to nerve conduction studies are a...
Qualitative assessment by the Heckmatt scale (HS) and quantitative greyscale analysis of muscle echogenicity were compared for their value in detecting intensive care unit-acquired weakness (ICU-AW). We performed muscle ultrasound (MUS) of eight skeletal muscles on day 3 and day 10 after ICU admission. We calculated the global mean greyscale score...
Purpose:
Brain death/death by neurologic criteria (BD/DNC) may be determined in many countries by a clinical examination that shows coma, brainstem areflexia, and apnea, provided the conditions causing reversible loss of brain function are excluded a priori. To date, accounts of recovery from BD/DNC in adults have been limited to noncompliance wit...
![Flowchart if CVST-TTS is suspected. Recommendations according to [31]....](publication/358731822/figure/fig2/AS:1144215207723008@1649813572524/Flowchart-if-CVST-TTS-is-suspected-Recommendations-according-to-31-A-Vaccination_Q320.jpg)
Cerebral venous and sinus thrombosis (CVST) after adenovirus-vectored COVID-19 ChAdOx1 nCov-19 (Oxford–AstraZeneca) and Ad26.COV2.S (Janssen/Johnson & Johnson) is a rare complication, occurring mainly in individuals under 60 years of age and more frequently in women. It manifests 4–24 days after vaccination. In most cases, antibodies against platel...
Headaches are a frequent reason for presentation to the emergency department (ED) and can pose a great challenge for the attending physicians. First and foremost, the distinction between a primary and secondary headache with potentially life-threatening implications can be difficult. Moreover, it often occurs that no specific headache diagnosis is...
Patients suffering from critical illness are at risk to develop critical illness neuromyopathy (CINM). The underlying pathophysiology is complex and controversial. A central question is whether soluble serum factors are involved in the pathogenesis of CINM. In this study, smooth muscle preparations obtained from the colon of patients undergoing ele...
Objective
The objective of this study is to find out whether gadolinium accumulation in the dentate nucleus (DN) after repeated gadolinium-based contrast agent (GBCA) administration in multiple sclerosis (MS) patients is related to tissue alteration detectable on transcranial ultrasound.
Methods
In this case–control study, 34 patients (17 with, an...
The most important predictors for outcomes after ischemic stroke, that is, for health deterioration and death, are chronological age and stroke severity; gender, genetics and lifestyle / environmental factors also play a role. Of all these, only the latter can be influenced after the event, even though recurrent stroke may be prevented by antiaggre...
The most important predictors for outcomes after ischemic stroke, that is, for health deterioration and death, are chronological age and stroke severity; gender, genetics and environmental factors also play a role. Of all these, only the latter can be influenced after the event, even though recurrent stroke may be prevented by antiaggregant/anticoa...
Background: The care of patients with headache in the emergency department (ED) represents a diagnostic and clinical challenge. Data on the prevalence and characteristics of headache patients in purely neurological EDs are sparse. The aim of the present study is to examine patient profiles with the cardinal symptom of headache in an academic neurol...
Objective
Venous thromboses and thrombocytopenia after vaccination with the adenovirus-vectored COVID-19 vaccine ChAdOx1 nCov-19 (AstraZeneca) have been linked to serum antibodies against platelet factor 4 (PF4)–polyanion complexes. We here report vaccine-induced isolated carotid arterial thrombosis.
Methods
Imaging and laboratory findings, treatm...
Objective
Ischemic stroke, as well as intracerebral hemorrhage (ICH), involving the insular cortex tends to be more severe. The impact of insular involvement on outcome of ICH remains enigmatic.
Methods
We analyzed 159 patients with supratentorial ICH. Depending on insular involvement the patients were classified into two groups (ICHnon-insular vs...
Background
Vaccine-induced cerebral venous and sinus thrombosis (VI-CVST) is a rare complication in recipients of the adenovirus-vectored coronavirus disease 2019 (COVID-19) vaccine ChAdOx1 nCov-19 (Vaxzevria®; AstraZeneca).Objectives
Development of a diagnostic and therapeutic standard.Materials and methodsAnalysis of clinical and basic research f...
Background and Objectives: Thus far, tumor control for choroidal melanoma after teletherapeutic radiation is clinically difficult. In contrast to brachytherapy, the tumor height does not necessarily have to shrink as a result of teletherapy. Therefore, the objective of this study was to evaluate tumor vascularization determined by color Doppler flo...
Citation: Fietzek, U.M.; Nene, D.; Schramm, A.; Appel-Cresswell, S.; Košutzká, Z.; Walter, U.; Wissel, J.; Berweck, S.; Chouinard, S.; Bäumer, T. The Role of Ultrasound for the Personalized Botulinum Toxin Treatment of Cervical Dystonia. Toxins 2021, 13, 365. https://doi.
Botulinum toxin (BT) therapy is a complex and highly individualised therapy defined by treatment algorithms and injection schemes describing its target muscles and their dosing. Various consensus guidelines have tried to standardise and to improve BT therapy. We wanted to update and improve consensus guidelines by: (1) Acknowledging recent advances...
Background:
Neuroimaging has been used to support a diagnosis of possible multiple system atrophy (MSA). Only blood pressure changes upon standing are included in the second consensus criteria but other autonomic function tests (AFT) are also useful to diagnose widespread and progressive autonomic failure typical of MSA. Additional diagnostic tool...
Fragestellung: Kennzeichnend für neuromuskuläre Erkrankungen sind die im neuromuskulären Ultraschall detektierbare Muskelatrophie sowie eine erhöhte Muskelechogenität. Software-basierte Graustufenanalyse (GS) und die visuelle
Graduierung anhand des Heckmatt Scores (HS) stellen hierbei Verfahren zur Quantifizierung von sonographischen Echogenitätsve...
Introduction:
Ageing-related processes such as cellular senescence are believed to underlie the accumulation of diseases in time, causing (co)morbidity, including cancer, thromboembolism and stroke. Interfering with these processes may delay, stop or reverse morbidity. The aim of this study is to investigate the link between (co)morbidity and agei...
Zusammenfassung
In der akademischen und öffentlichen Debatte wird der irreversible Hirnfunktionsausfall als Kriterium des Todes (Hirntodkriterium) immer wieder hinterfragt. Im vorliegenden Artikel werden 6 prototypische Thesen gegen das Hirntodkriterium diskutiert: 1) Nichtsuperiorität des Gehirns gegenüber anderen Organen, 2) Unsicherheit der Hirn...
Background
In the current consensus diagnostic criteria, the diagnosis of probable multiple system atrophy (MSA) is based solely on clinical findings, whereas neuroimaging findings are listed as aid for the diagnosis of possible MSA. There are overlapping phenotypes between MSA‐parkinsonian type (MSA‐P) and Parkinson's disease, progressive supranuc...
Background:
Detection of atrial fibrillation (AF) after cryptogenic stroke (CS) has therapeutic implications, but the most effective type and optimal duration of monitoring have still to be defined. This study that involved patients with CS or transient ischemic attack (TIA), all of whom carried an implantable cardiac monitor (ICM), sought to asse...
Objective
To investigate the risk factors of neutralizing antibody (NAB)–induced complete secondary treatment failure (cSTF) during long-term botulinum neurotoxin (BoNT) treatment in various neurologic indications.
Methods
This monocenter retrospective cohort study analyzed the data of 471 patients started on BoNT therapy between 1995 and 2015. Bl...
Aging-related processes such as cellular senescence are believed to underlie the accumulation of diseases in time, causing (co-)morbidity, including cancer, thromboembolism and stroke. Intervening into these processes may delay, stop or reverse morbidity. To study the link between (co-)morbidity and aging, by exploring biomarkers and molecular mech...
Background:
Symptomatic epileptic seizures are an important complication in subarachnoid haemorrhage (SAH) with a frequency of 0.9-25% with importance for patient outcome. The majority of previous studies investigated the incidence of symptomatic epileptic seizures after aneurysmatic SAH. Here we compared the seizure incidence and its impact on th...
Die Feststellung des irreversiblen Hirnfunktionsausfalls (IHA) erfolgt in Deutschland gemäß Richtlinie der Bundesärztekammer, deren vierte Fortschreibung seit Juli 2015 gültig ist. Im vorliegenden Beitrag erfolgt eine aktuelle Standortbestimmung. Internationale Fallberichte mit vermeintlich unzutreffender IHA-Diagnose werden aus Sicht der deutschen...
Objective
X‐linked dystonia‐parkinsonism (XDP) is a neurodegenerative movement disorder caused by a single mutation: SINE‐VNTR‐Alu (SVA) retrotransposon insertion in TAF1. Recently, a (CCCTCT)n repeat within the SVA insertion has been reported as an age‐at‐onset (AAO) modifier in XDP. Here we investigate the role of this hexanucleotide repeat in mo...
Background:
Intensive care unit-acquired weakness (ICU-AW) is associated with poorer outcome of critically ill patients. Microcirculatory changes and altered vascular permeability of skeletal muscles might contribute to the pathogenesis of ICU-AW. Muscular ultrasound (MUS) displays increased muscle echogenicity, although its pathogenesis is uncert...
Introduction
The standard ultrasonographic measurement tools (trace, ellipse) of cross‐sectional areas (CSA) of very small nerves typically yield rough measures in full square millimeters.
Methods
In 70 volunteers, the elliptically shaped CSAs of mid‐cervical vagus, accessory and phrenic nerves were estimated with three methods: two on‐board tools...
Ein spezielles Verfahren zur Feststellung des Todes ist die Diagnostik des irreversiblen Hirnfunktionsausfalls (IHA). Darunter versteht man den endgültigen, nicht behebbaren Ausfall der Gesamtfunktion des Großhirns, des Kleinhirns und des Hirnstamms bei einer durch kontrollierte Beatmung aufrechterhaltenen Herz- Kreislauf-Funktion. Die IHA-Diagnost...
INTRODUCTION: Intensive care unit-acquired weakness (ICU-AW) is
associated with weaning failure and unfavorable outcome in critically
ill patients. Muscular ultrasound (MUS) is a non-invasive diagnostic
tool that is able to display increased muscle echogenicity, which was
linked to neuromuscular dysfunction.
OBJECTIVES: To evaluate the prognostic v...
Background: The vagus nerve has been suggested to represent one major route of disease progression in Parkinson's disease (PD). Here, we examined whether patients with idiopathic PD exhibit an atrophy of the vagus nerve in comparison to age-matched controls.
Methods: In this cross-sectional study, performed between July 2017 and January 2018, we me...
To explore the molecular processes underlying some biological theme of interest based on public data, gene lists are used herein as input for the construction of annotated pathway maps, employing Cytoscape apps, and then high-throughput ("omics") gene expression data are overlaid onto these maps. Seeded with a published set of marker genes of the s...
The widely accepted concept of brain death (BD) comprises the demonstration of irreversible coma in combination with the loss of brainstem reflexes and irreversible apnea. In some countries the combined clinical finding of coma, apnea, and loss of all tested brainstem reflexes ("brainstem death") is sufficient for diagnosing BD irrespective of the...
The obliquus capitis inferior (OCI) muscle may be crucially involved in generating the tremulous component of spasmodic torticollis. This study was undertaken to evaluate the efficacy of a simplified ultrasonography-guided approach of botulinum neurotoxin injection into the OCI in the management of spasmodic torticollis. Here, a novel off-plane tec...
Spasticity is a symptom occurring in many neurological conditions including stroke, multiple sclerosis, hypoxic brain damage, traumatic brain injury, tumours and heredodegenerative diseases. It affects large numbers of patients and may cause major disability. So far, spasticity has merely been described as part of the upper motor neurone syndrome o...
Dear Editor;
External defibrillation in patients with implanted neuromodulatory devices is a crucial therapeutic challenge. We report a 63-year-old male patient with refractory epilepsy (RE) after recurrent ischaemic strokes in the middle cerebral artery and in the anterior cerebral artery territory 26 and 23 years ago. He received various therape...
There are several issues, which have to be acknowledged, when treating women with epilepsy (WWE). The need for counseling WWE in Germany with epilepsy on pregnancy-related matters was stressed in several papers and medical guidelines. Physicians treating WWE in Germany therefore should be aware of the information needs of their patients. We aimed t...
Background:
The guidelines of the German Medical Association and the German Society for Clinical Neurophysiology and Functional Imaging (DGKN) require a high procedural and technical standard for electroencephalography (EEG) as an ancillary method for diagnosing the irreversible cessation of brain function (brain death). Nowadays, digital EEG syst...
Background:
The clinical diagnosis of idiopathic Parkinson's disease (iPD) can be challenging. In these cases, additional diagnostic methods are available that can help to improve diagnostic accuracy.
Objectives, material and methods:
This article provides an overview of currently available and promising novel ancillary methods for the early and...
Zusammenfassung
Die transkranielle B-Bild-Sonographie (TCS) des Mittelhirns – insbesondere der Substantia nigra (SN) und der Raphe – wird zunehmend als Instrument zur Diagnostik des Parkinson-Syndroms und weiterer Hirnerkrankungen eingesetzt. Eine ausreichende Schulung und Einarbeitung vorausgesetzt, kann die TCS des Mittelhirns von Ärzten und medi...
Background and objectives:
Nowadays, there is an ongoing discussion about the risks and benefits of anesthetic treatment concerning outcome in status epilepticus (SE). Therefore, we performed a retrospective database analysis to examine the influence of treatment with anesthetic drugs and narcosis in SE on mortality and disability.
Methods:
All...
Background:
Recently, the Movement Disorder Society (MDS) published an adaptation of the previous United Kingdom Brain Bank Society (UKBBS) criteria for the diagnosis of idiopathic Parkinson's disease (iPD).
Objectives:
This article presents the changes in the current clinical diagnostic criteria for IPD. Furthermore, the new MDS criteria for pr...
Introduction:
X-linked recessive dystonia-parkinsonism (XDP, DYT3) is highly prevalent in the Philippines and manifests with varying phenotype. We sought to evaluate the significance of transcranial brain sonography as a biomarker for parkinsonism-predominant phenotype.
Methods:
90 Filipino participants were enrolled into a cross-sectional study...
The differentiation between the clinical and electroencephalographic changes in nonconvulsive status epilepticus (NCSE) and those in sporadic Creutzfeldt-Jakob disease (sCJD) is a crucial question.
A 77-year old woman was admitted because of fluctuating behavioural changes, adynamia and apraxia since several months for diagnostic. The diagnosis of...
Botulinum toxin (BT) therapy is an established treatment of spasticity due to stroke. For multiple sclerosis (MS) spasticity this is not the case. IAB-Interdisciplinary Working Group for Movement Disorders formed a task force to explore the use of BT therapy for treatment of MS spasticity. A formalised PubMed literature search produced 55 publicati...
Objective: We conducted a study on knowledge and attitude towards epilepsy in Afghanistan, where there is no previous report, where Islam coexist with shamanistic concepts derived from earlier beliefs and practices. Methods: A self-administered questionnaire consisting of 19 questions and 72 items, based on questions used in previous studies was di...
Introduction:
The involvement of the serotonergic system of the brainstem raphe in the pathogenesis of migraine is discussed. Here we studied brainstem alterations in migraineurs using transcranial sonography and examined their relation to clinical features and self-medication.
Methods:
We investigated 51 migraineurs (11 men, 40 women, mean age...
Purpose: Transcranial B-mode sonography (TCS) of brain parenchyma is increasingly used as a diagnostic tool for movement disorders. Accordingly, experimental B-Mode Assist software was developed to enable digitized analysis of the echogenicity of predefined brain regions. The aim of the study was to assess the reproducibility of digitized TCS image...
The molecular dysfunction in X-linked dystonia-parkinsonism is not completely understood. Thus far, only noncoding alterations have been found in genetic analyses, located in or nearby the TATA-box binding protein-associated factor 1 (TAF1) gene. Given that this gene is ubiquitously expressed and is a critical component of the cellular transcriptio...
A growing body of evidence supports a prodromal neurodegenerative process preceding the clinical onset of Parkinson's disease (PD). Studies have identified several different prodromal markers that may have the potential to predict the conversion from healthy to clinical PD but use considerably different approaches. We systematically reviewed 35 lon...
Enormous effort is being put into the identification and characterization of symptoms that may be used as predictive and progression markers in Parkinson’s disease (PD). An impressive number of PD patients and individuals at risk for or in the prodromal stage of PD are currently followed in longitudinal studies, however, there does not exist an ove...
Parkinson's disease (PD) is an example for a complex field of research, which is driven by the multifactorial etiology, the heterogeneity in phenotype and the variability in disease progression, as well as the presence of a long pre-diagnostic period, called prodromal PD, lasting up to decades (Postuma et al., 2010). The very slow, so far inevitabl...
Background
Neurological deficits, epileptic seizures, quantitative and qualitative disturbances of consciousness in the context of febrile (even nonneurological) disorders are relatively common. The spectrum ranges from childhood febrile convulsions to septic encephalopathy. Specific neurological disorders with fever as the leading symptom are the...
Background:
Enormous effort is being put into the identification and characterization of symptoms that may be used as predictive and progression markers in Parkinson's disease (PD). An impressive number of PD patients and individuals at risk for or in the prodromal stage of PD are currently followed in longitudinal studies; however, there does not...
Panic disorder has been associated with altered serotonin metabolism in the brainstem raphe. The aim of study was to evaluate the BR echogenicity on transcranial sonography (TCS) in panic disorder. A total of 96 healthy volunteers were enrolled in the "derivation" cohort, and 26 healthy volunteers and 26 panic disorder patients were enrolled in the...
Background:
A combination of preoperative magnetic resonance imaging (MRI) with real-time transcranial ultrasound, known as fusion imaging, may improve postoperative control of deep brain stimulation (DBS) electrode location. Fusion imaging, however, employs a weak magnetic field for tracking the position of the ultrasound transducer and the patie...
Objective
It was planned to investigate, whether certain electroencephalographic patterns obtained during the treatment of a status epilepticus (SE) were associated with a particular subtype of SE.
Methods
In a retrospective databank analysis all treatment episodes of a SE between January 1st 2000 and December 31st 2009 in the department of Neurol...
Ziel der Studie: Während der Behandlung eines Status epilepticus abgeleitete elektroenzephalografische Muster sollen hinsichtlich ihrer Assoziation zu bestimmten Subtypen eines Status epilepticus (SE) und ihrer prognostischen Bedeutung untersucht werden.
Methodik: In einer retrospektiven Datenbankanalyse wurden alle Behandlungsepisoden eines SE in...
Choroidal melanoma is the most frequently occurring intraocular tumor in adults. The aim of this work is to assess the potential of state-of-the art in-vivo and ex-vivo imaging modalities for the characterization of choroidal melanoma. Multimodal imaging of a choroidal melanoma was performed in a 53-year-old male patient. In-vivo ophthalmoscopy, ul...
The results of register studies suggest an association between Parkinson's disease (PD) and melanoma. We studied the frequency and profile of early markers of PD in patients with malignant melanoma.
100 participants were enrolled in a prospective observational study, of whom 65 had a history of high-risk cutaneous (n=53) or uveal (n=12) melanoma (3...
Botulinum neurotoxin A (BoNT A) is the first-line treatment for cervical dystonia. However, although BoNT A has a favorable safety profile and is effective in the majority of patients, in some cases the treatment outcome is disappointing or side effects occur when higher doses are used. It is likely that in such cases either the target muscles were...
Hintergrund
Im Rahmen der Hirntoddiagnostik werden regelmäßig toxikologische Untersuchungen zum Ausschluss therapeutischer Serumkonzentrationen nach Applikation zentral dämpfender Medikamente durchgeführt. Zu Propofol und Sufentanil fehlen einheitliche Empfehlungen zur Einordnung toxikologischer Befunde.
Fragestellung
Es soll ein Standardvorgehe...
Major depressive disorder (MDD) has been associated with an increased risk of subsequent Parkinson's disease (PD) in case-control and cohort studies. However, depression alone is unlikely to be a useful marker of prodromal PD due to its low specificity. In this longitudinal observational study, we assessed whether the presence of other potential ma...
Botulinum toxin (BT) therapy is used in neurology to treat muscle hyperactivity disorders including dystonia, spasticity, cerebral palsy, hemifacial spasms and re-innervation synkinesias as well as exocrine gland hyperactivity disorders. To increase its therapeutic effect and to decrease adverse effects in adjacent tissues, exact BT placement is im...
Transcranial B-mode sonography (TCS) of brain parenchyma is being increasingly used as a diagnostic tool in movement disorders. Compared to other neuroimaging modalities such as magnetic resonance imaging (MRI) and computed tomography, TCS can be performed today with portable machines and has the advantages of noninvasiveness and high resistance to...
In patients with Wilson's disease (WD) transcranial brain sonography typically reveals areas of increased echogenicity (hyperechogenicity) of the lenticular nucleus (LN). Correlation with T2-hypointensity on magnetic resonance images suggested that LN hyperechogenicity in WD is caused by trace metal accumulation. Accumulation of both, copper and ir...
A combination of magnetic resonance images with real-time high-resolution ultrasound known as fusion imaging may improve ophthalmologic examination. This study was undertaken to evaluate the feasibility of orbital high-field magnetic resonance and real-time colour Doppler ultrasound image fusion and navigation.
This case study, performed between Ap...
Background:
Tremulous Parkinson's disease (PD) and essential tremor are well known to be associated, but characteristics of progression of pure tremor state to PD remain unclear.
Objective:
In this prospective study a cohort of 16 patients suffering from a suggested new disease entity was clinically, pharmacologically, and sonographically analyz...
The detection of Parkinson's disease (PD) at stages earlier than current diagnostic criteria allow for may increase the efficacy of disease-modifying therapies. Here we studied the relationship between retrospectively reported prodromal non-motor and motor features of PD, their pre-diagnostic presentation to physicians, and the extrapolated potenti...
Citations
... 27 In addition, a recent comprehensive retrospective analysis of 5 centers in Germany between 2008 and 2021 demonstrated the benefit of surgical decompression in patients with larger stroke volumes. 30 Such evidence highlights the potential of our biomarker profile to rule in ICH in the setting of low D-dimer/high GFAP, and prompt neurosurgical referral may also have therapeutic utility. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281175482813-1689749767241_Q64/Sae-Yeon-Won-2.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/853327004831747-1580460420748_Q64/Silvia-Hernandez-Duran.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/659494468067339-1534247142602_Q64/Bedjan-Behmanesh.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281172023105-1688424054333_Q64/Joshua-Bernstock.jpg)
... Cerebellar edema can block aqueducts and the fourth ventricle and cause hydrocephalus and, in severe cases, herniation of cerebellar tonsils in the 1 2 3 4 2 2 2 2 5 6 2 foramen magnum, causing sudden death [3]. Numerous studies have reported that advanced age, low Glasgow Coma Scale (GCS) scores, and the development of hydrocephalus are substantial risk factors for adverse outcomes [3][4][5][6]. Both ischemic and hemorrhagic infarctions can result in cerebellar stroke, which is highly correlated with long-term hypertension and the use of anticoagulants or antiplatelets. ...
... [4], spinocerebellar ataxia [5] and Parkinson's disease [6]. In addition to these diagnostic applications, nerve HRUS cross-sectional area (CSA) measurements offer a unique opportunity to analyze human peripheral nerve size in vivo over a wide age range. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281088263165-1664990483251_Q64/Ramy_Abdelnaby.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281091570012-1666549438046_Q64/Ahmed-Shabib-3.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1092622336692227-1637512873369_Q64/Khaled-Mohamed-20.jpg)
... In the present study, muscle loss was assessed using ultrasound as a decrease in the RFCSA of ≥ 10% to define muscle wasting, and muscle wasting was predictive of prolonged hospital stay in critically ill patients with acute brain injury. Comparison of study results is difficult because there is no consensus on the optimal measurement protocol for muscle ultrasound, and image quality can be affected by factors related to the practitioner and the patient [56]. To more precisely characterize skeletal muscle wasting, integration of different parameters may be necessary. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281106867970-1670871595421_Q64/Felix-Klawitter.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/276500881395719-1442934355977_Q64/Hubertus-Axer.jpg)
... Consequently, NRF2 accumulates in the nucleus and activates the expression of cytoprotective genes via the ARE complex [81]. Furthermore, kinase proteins, including PI3K-AKT, protein kinase C (PKC), AMP-activated protein kinase (AMPK), and mitogen-activated protein kinases (MAPKs), which are activated in the brain by both acute and chronic exercise [93][94][95], promote NRF2 phosphorylation and increase its stability and subsequent transcriptional activity [83][84][85], seeking to maintain brain redox balance [96]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/273690818510867-1442264384398_Q64/David-Devos.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1118625079537664-1643712410482_Q64/Caroline-Moreau-3.jpg)
... Researchers in large numbers are working hard to make diagnostic and therapeutic progress with regard to cancerous tumors (Babich et al., 2022). Despite the fact that several studies has resulted in several significant breakthroughs, the difficult conditions present within tumour microenvironments remain a major obstacle to the development of novel cancer treatment approaches (Revskij et al., 2022). One of the most common approaches of treating cancer is chemotherapy, which is also sometimes referred to as chemotherapeutic therapy. ...
... The iron chelator Deferiprone (DFP) is Phase II for Parkinson's disease (NCT0094374), demonstrated good tolerability and reduced iron accumulation, although it didn't improve motor scores or cognitive impairment (Martin-Bastida et al., 2017). Conversely, a large phase II study for Parkinson's disease (NCT02655315), demonstrated that patients treated with DFP experienced worse symptoms than those receiving placebo, despite lower iron content in the substantia nigra (Devos et al., 2022). N-acetyl cysteine (NAC) is under investigation in Parkinson's disease clinical trials (NCT02212678) with potentially promising results targeting ferroptosis (Monti et al., 2019). ...
... It has been found that FM affects brain morphometry (24), and that FM patients may have a unique retinal signature (25). Other imaging studies have shown a trend towards decreasing volumes in the right anterior insular cortex (rAIC) of three subgroups showing an increased number of areas experiencing pain (26), and reduced echogenicity in the midbrain raphe area of patients with FM or depression and physical pain regardless of the presence or severity of the pain, FM or depressive symptoms (27). Neuro-inflammation is also important. ...
Reference: Fibromyalgia: one year in review 2023
![[object Object]](https://i1.rgstatic.net/ii/profile.image/417417063878656-1476531391808_Q64/Nurcan-Ueceyler.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281168368992-1686956536347_Q64/Jakub-Radziwon-2.jpg)
... 8 A person's self-confidence can affect behavior, thoughts, expectations and affect our attitudes towards ourselves and others and affect the way we face reality. 9 The great persuasive power of scientific pronouncements has led some to claim that scientific theories, models, or predictions may or even have themselves become self-fulfilling in a manner similar to that of the prophecy of Oedipus. 10 From a literary perspective, this is certainly an intriguing suggestion to someone with full expectations of a self-fulfilling prophecy. 11 ...
... Both CRP and fibrinogen are critical factors that occur during the acute phase response to inflammation and serve as key acute-phase proteins (46, 47). Activation of the coagulation system is widely acknowledged to be initiated by inflammation, resulting in an increase in prothrombin and antifibrinolytic factor levels (48,49). In contrast, elements within the coagulation system, including fibrinogen or fibrin, can independently trigger the onset of the inflammatory process and contribute to the development of subsequent tissue damage downstream (50). ...
