Tytti Kärkkäinen's research while affiliated with Medix Biochemica and other places

... IGFBP-1 levels were not significantly different between patients with or without diabetes (p = 0.5230 for the AL group and p = 0.6708 for the PR group) and between those with a BMI ≥ 30 kg/m 2 and those with a BMI < 30 kg/m 2 (p = 0.6985 for the AL group and p = 0.2001 for the PR group). Age is another parameter related to increased circulating IGFBP-1 levels 52 . We analyzed the correlation between serum IGFBP-1 levels and age ( Supplementary Fig. S1) and found a moderate, significant correlation in the PR group (r = 0.3806, p = 0.0347) compared with a weak and not statistically significant correlation in the AL group (r = 0.2184; p = 0.1940). ...

... However, a recent French report (9) found that the incidence of cases of latex anaphylaxis is decreasing as a result of the identification of at-risk patients, improved testing, and preventive measures. In addition, many manufacturers are decreasing latex in a variety of products (10). There is currently no cure for latex allergy, and avoidance of latex-containing products is mandatory for affected individuals. ...

... The role of a long standing subclinical inflammation in the genesis of preterm labour has been highlighted by Ghezzi et al. [35], who showed that higher amniotic levels of C-reactive protein in low-risk patients undergoing genetic amniocentesis are significantly associated with the risk of a premature delivery. Moreover, the risk of preterm labour seems to be higher in women with uterine contractions but intact membranes who show increased levels of insulin-like growth factor-binding protein-1 (IGFBP-1) in the cervical secretion [37]. The activation and release of IGFBP-1 by decidua is part of the biochemical cascade which is elicited by a inflammatory trigger such as vaginosis and may lead to preterm labour [38]. ...

... The primary problem in the diagnosis of PROM is to distinguish small amounts of amniotic fluid from other body fluids which may be present in the vagina. A number of non-invasive methods, based on; cytologic, biochemical or biophysical differences between amniotic fluid and other body fluids, have been proposed and used [7] . ...

... According to studies, it is considered more sensitive and specific than the Amnisure test [19]. Those with intact membranes are essentially excluded by a negative test result [20]. It has been proposed that if a patient tests negative, further c-reactive protein (CRP) and white blood cell (WBC) counts must be done to exclude infections [21]. ...

... IGFBP-1, which is a major protein of human decidua, constitutes a subgroup of the IGFBP system. IGFBP-1 has a higher concentration in amniotic fluid than in serum; its concentration gradually increases in the amniotic fluid in the mid-trimester in comparison with its concentration in the maternal plasma 24 . ...

... Serum GH, IGFBP-3, and IGFBP-1 were measured by commercial assays: GH by a noncompetitive assay (DELFIA GH, Wallac Oy, Turku, Finland) (15), IGFBP-3 by radioimmunoassay (Diagnostic System Laboratories Inc., Webster, TX), and IGFBP-1 by enzyme-linked immunosorbent assay (ELISA) (Medix Biochemica, Kainiainen, Finland). This IGFBP-1 kit measures the non-and lesser phosphorylated isoforms of IGFBP-1 (13,16). ...

... The selected anti-CRP mAb has an ultrahigh picomolar level affinity for CRP binding. 29 Similar to the bio-BSA/SA pair, the binding between CRP and the specific anti-CRP mAb resulted in an increase in the TRL-signal at RT, whereas the nonspecific mAbs had no significant impact on the signal (Figure 3, Figure S2). Within the studied concentration ranges, the observed TRL signal between the protein complex and mAb alone peaked at the approximate ratio of 5:1 (mAb/CRP) independent of the protein concentration level. ...

... In the present study, PAH patients showed increased plasma IGFBP-1 levels compared to healthy controls. It is important to note that the present PAH patients were older than the controls, and that IGFBP-1 may increase with age [25]. However, in the present patient and control cohorts, we found no correlations between age and plasma IGFBP-1. ...

... Crosstalk between sex hormones and the insulin/IGF axis has been identified, as estrogens were reported to increase the expression of IGF-1 in the uterus, while [114] progesterone was found to increase the synthesis of IGF-binding proteins and antagonize estrogen-induced cell proliferation [115,116]. To date, there is limited and inconsistent data on the role of IGF-1 in endometrial cancer [117][118][119][120][121]. The biological actions of IGF are mediated through its receptors, especially IGF-1R, which undergoes autophosphorylation of its domain and activates the RAS-RAF-MAP kinase and the PI3K-PDK1-Akt/PKB signaling pathways, which results in cell proliferation and a decrease in cell apoptosis [122]. ...