Tsuyoshi Hamada's research while affiliated with Japanese Foundation for Cancer Research and other places

... Furthermore, necrosectomy is less often required during early EUS-D. In our meta-analysis of 235 cases of POPFCs, 48 there were no significant differences in clinical success and AE between early and delayed EUS-D, although all studies included in the analysis were retrospective. ...

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Drainage for fluid collections post pancreatic surgery and acute pancreatitis: similar but different?

... Cancer remains a leading cause of death worldwide, posing a significant burden on global health. 1,2 The high incidence of cancer may be caused by several factors, such as genetic mutations, environmental factors, insufficient physical activity, diverse lifestyles, unstable behaviors related to diet, smoking, and alcohol consumption. [3][4][5][6][7] The current treatment methods for different stages of various cancers include chemotherapy, radiation therapy, and surgical procedures for solid tumors, or a combination of the above. ...

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Drug repurposing for cancer therapy

... Severe bleeding associated with lumen-apposing metal stent placement for walled-off necrosis: bloody memory in WONderland Lumen-apposing metal stents (LAMSs) may facilitate endoscopic ultrasound (EUS)-guided treatment of walled-off necrosis (WON) as a transluminal port for necrosectomy [1,2]. However, this modality has a risk of potentially lethal bleeding [3,4]. ...

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Severe bleeding associated with lumen-apposing metal stent placement for walled-off necrosis: bloody memory in WONderland

... Therefore, the utility of CNN-based stratification of risk of post-ERCP pancreatitis should be investigated in patients receiving ERCP overall. In addition, scoring systems based on different sets of clinical parameters from the current study have been reported for prediction of post-ERCP pancreatitis [34,35]. Therefore, future research is warranted to investigate whether integration of deep learning-based image recognition with these scoring systems improves predictive ability. ...

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Computed tomography-based prediction of pancreatitis following biliary metal stent placement with the convolutional neural network

... Their BART model, utilizing seven robust and relevant variables, yielded AUCs ranging from 0.67 to 0.83 (median: 0.74) through five-fold crossvalidation. The relatively elevated AUC could potentially be attributed to a richer dataset, as their investigation analyzed 75 clinicopathologic, immune, microbial, and genomic factors within 815 stage II-III patients across two comprehensive U.S.-wide prospective cohorts, resulting in the identification of seven consistent survival predictors [21]. Additionally, Gupta et al. pursued a study employing data mining techniques and extant CRC risk prediction models, wherein deep autoencoders achieved exceptional performance outcomes, attaining 95% AUC. ...

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Classification and Diagnostic Prediction of Colorectal Cancer Mortality Based on Machine Learning Algorithms: A Multicenter National Study

... There are no apparent causal factors associated with the oncogenesis and progression of pancreatic cancer; however, the major modifiable risk factors are tobacco smoking, obesity, diabetes mellitus, and alcohol intake [3]. Mutations in tumor protein 53, cyclin-dependent kinase inhibitor 2A, Kirsten rat sarcoma, and small mothers against decapentaplegic homolog 4 (SMAD4) have been recognized as major drivers of pancreatic carcinogenesis [4]. Surgical resection remains the preferred treatment for resectable pancreatic tumors. ...

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Harnessing Plant Flavonoids to Fight Pancreatic Cancer

... The WONDER-02 trial has been designed and will be implemented by the WONDERFUL (WON anD pERipancreatic FlUid coLlection) study group in Japan, which consisted of expert endoscopists, gastroenterologists, interventional radiologists, and epidemiologists at high-volume centres in Japan (5,6,8,25,(28)(29)(30). ...

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WONDER-02: plastic stent vs. lumen-apposing metal stent for endoscopic ultrasound-guided drainage of pancreatic pseudocysts—study protocol for a multicentre randomised non-inferiority trial

... The optimal timing to perform necrosectomy for patients with pancreatic necrosis is still evolving [30]. According to the 2020 clinical practice update from the American Gastroenterological Association, the optimal timing for pancreatic debridement should be around four weeks [31]. ...

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Early versus delayed necrosectomy in pancreatic necrosis: A population-based cohort study on readmission, healthcare utilization, and in-hospital mortality

... Sarcopenia at cancer diagnosis may serve as a surrogate for various cancer-related factors with negative impacts on survival times, including impaired nutritional status, unfavorable metabolic alterations, and sustained systemic inflammation [10]. Further research suggests that clinical outcomes of cancer patients may depend on postdiagnostic alterations in skeletal muscle status due to the invasiveness of surgery [11,12] or the toxicity of chemotherapy [13][14][15]. A better understanding of the pathogenesis of skeletal muscle alterations in the context of postdiagnostic clinical course of cancer patients would help to develop and implement new management strategies of the patients [16]. ...

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Skeletal muscle status and survival among patients with advanced biliary tract cancer

... IPMN is the most common reason for significant MPD dilatation. At the same time, a correlation was noted between the degree of duct dilatation and the likelihood of malignant tumor development [6]. According to Hamada T. et al. [6] among all patients with IPMN, the number of patients with MPD dilatation Giant dilatation of pancreatic duct associated with congenital anomaly | 3 (H and E, × 200). of more than 5 mm is 10%, and 26% of them had malignancy. ...

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Giant dilatation of pancreatic duct associated with congenital anomaly of the pancreatic ductal system and small neuroendocrine tumor