Topul Rali's research while affiliated with ETH Zurich and other places

... One of the distinctive features of plasma NEFA (and tissue fatty acid composition) in temperate marine teleosts is a high ratio of n-3/n-6 fatty acids (4.7 to 14.4) due to elevated levels of DHA and EPA, which are common in cold-water food chains and have important roles in the function of cold-adapted membranes in fishes (Henderson and Tocher, 1987; Hazel and Williams, 1990; Ballantyne et al., 1993). The tissue lipids of tropical marine teleosts, on the other hand, contain less DHA and more AA and its elongation product docosatetraenoic acid (22:4n-6), resulting in lower n-3/n-6 ratios (Sinclair et al., 1983; Gibson et al., 1984; Hansel et al., 1993). In fact, Sinclair et al. (1984) demonstrated that the relative n-6 fatty acid content in fishes increased as sampling occurred closer to the equator. ...

... To the best of our knowledge, this is the first report of the antifungal activity of compounds 1 to 14 against the three phytopathogenic fungi studied. In addition, no reports have been found in the literature of antifungal activity against other phytopathogenic fungi for compounds 1 to 3, 8 to 10 and 12 to 14, while antifungal activity has been reported against C. cladosporoides and C. sphaerospermum for 4 [44], and Penicillium oxalicum for 11 [46]. The maximum concentration evaluated was 200 µg/mL. ...

... After a 75-day study, it was shown that the provision of durian seed flour and Kelakai leaf flour had a very significant effect on the growth in length and weight of Nile tilapia reared. Treatment B, providing feed formulation of peeled with durian seed flour and Kelakai leaf flour as much as 5% of body weight per day resulted in the highest growth in length and weight of fish (Amid & Mirhosseini, 2012;Liu et al., 1998;Sifa et al., 2002). Thus the treatment of provision feed formulations of peeled durian seed flour and Kelakai leaf flour made a positive contribution to the growth of the length and weight of Nile tilapia. ...

... Compared with 3,20-dihydroxylupane, the downfield of H-3 (+1.34), C-3 (+2.4) and upfield of C-2 (-3.9) of 1 indicated that the fatty acid was esterified with 3-OH [19,20], which was confirmed by the correlation of H 4.54 (H-3) and C 172.7 (C-1') in the HMBC spectrum ( Figure 3). Thus, the structure of compound 1 was elucidated and named as lupan-20-ol-3()-yl 3-hydroxyoctadecanoate. ...

... Among the other Ficus species, F. septica extract showed strong antibacterial activity against E. coli, both ethyl acetate (leaves), and methanol (leaves and stem) extracts. A similar study reported that the methanol extract of F. septica leaves displayed antimicrobial activity, this extract contains two indolizidine alkaloids, the novel ficuseptine 4,6-bis-(4-methoxyphenyl)-1,2,3-trihydrolndolizidinium chloride, and antofine [26]. A study performed by Vital et al. [27] showed the presence of alkaloids, quaternary base, tannin, 2-deoxysugars, and benzopyrone nucleus in leaves of F. septica extract, and this extract revealed antimicrobial activity inhibiting the growth of S. aureus, E. coli, and Candida albicans with inhibition zone diameter of 13.83±4.01, ...

... Diuretic drugs are clinically used to the treatment of oedema, hypertension, urolithiasis and others diseases (Orjala et al., 1992;Pietrow and Karellas, 2006;Rose, 1991;Wright et al., 2007). Urolithiasis is a disturbance that affects kidney, which is considered a systemic disorder associated with bone loss and fractures, chronic kidney disease, hypertension, increased risk of coronary artery disease, metabolic syndrome, and type-2 diabetes mellitus (Sakhaee et al., 2012). ...

... In this regard, antofine and other related natural or synthetic alkaloids have been the focus of several studies due to their ability to exhibit a large spectrum of interesting biological properties. Antofine and its natural derivatives were found to be distributed mainly in the Asclepiadaceae family plants Apocynaceae (Staerk et al. 2002), Lauraceae (Othman et al. 2017), and Moraceae (Damu et al. 2009;Baumgartner et al. 1989). These alkaloids were largely studied not only for their anticancer activity (Staerk et al. 2002;Chemler 2009;Gao et al. 2007a;Bour, et al. 2014), but also for their anti-inflammatory action (Yang et al. 2007), antifungal effect (Dhiman et al. 2012), and antiviral activity (Wu et al. 2013;Wang et al. 2014). ...

... Studies of the chemical composition of P. aduncum have focused mainly on the volatile compounds of the leaves [9][10][11]. In this paper, as a continuation of our studies on the essential oil compositions of Cuban aromatic species, we report the chemical composition of P. aduncum subsp. ...

... O xidative dearomatization reactions are found in the biosynthesis of many biologically active compounds in nature. 1 In chemical synthesis, many oxidative methods mediated by mainly transition metal or hypervalent iodine compounds have been developed for the dearomatization of arenols. 2 In this context, dearomative spirolactonization of arenols tethered to a carboxyl group as an intramolecular nucleophile have been developed using iodine-based catalysis (Scheme 1a). 3 Compared with spirolactonization, oxidative spiroetherification of arenols tethered to a hydroxy group and spiroamination of arenols tethered to a secondary amido group have been less explored, 2,4 despite their usefulness for the synthesis of core structures of many biologically important compounds. 5 Conventionally, these reactions were best performed using hypervalent iodine compounds as stoichiometric oxidants under acidic conditions. 4 Recently, the oxidative cyclization of arenols under stoichiometric (R 4 N + [Br 3 ] − /K 2 CO 3 ) 6 or catalytic (10 mol % RuCl 3 / KBrO 3 ) 7 conditions has also been reported. ...

... Phytochemical research of the alcoholic extract of M. tenuiflora green propolis led to the isolation of six compounds 1-6 ( Figure 1). Their NMR spectroscopic data (Figures S1-S12) match well with previous reports, including two flavones quercetin 3methyl ether (1) and 3,3'-O-dimethylquercetin (2), and four flavanones eriodictyol 5-O-methyl ether (3), 5,4'-dihydroxy-6,7dimethoxyflavanone (4), licoflavanone (5), and macarangaflavanone B (6). [6][7][8][9][10][11] From previous studies, propolis from Asian and European regions contained a significant concentration of flavonoids, while Brazilian propolis was only accompanied by terpenoids and prenylated coumaric acids. [12] Our current result can be seen as new evidence for the presence of flavonoids in Brazilian propolis. ...