Tomas Hudlicky's research while affiliated with Brock University and other places

... The number of unnatural derivatives of narciclasine reported in the literature is very small compared with those derived from pancratistatin. Thus, our group previously published efforts towards the total syntheses of narciclasine analogs, namely compounds 5-9 shown in Figure 1 [11][12][13][14]. 10-Aza-narciclasine (7) is the only derivative of narciclasine synthesized by our group that displayed activity comparable to that of the natural product [12]. ...

... The more elaborate synthesis of the C-ring coupling precursor, which contains all the necessary chiral centers of the final product, begins with the enzymatic dihydroxylation of ortho-dibromobenzene (13, Scheme 3). This is accomplished by a whole-cell fermentation process [20] with a recombinant strain of E. coli JM109 (pDTG601A [21]) that over-expresses toluene dioxygenase and was successfully used for the oxidative de-aromatization of various aromatic substrates [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] employed in the synthesis of natural products. Once dibromodiene diol 12 was obtained, it was subjected to acetonide protection and a nitroso Diels-Alder reaction in a one-pot procedure to form the bicyclic oxazine 21. ...

... There are not as many unnatural derivatives reported for the latter alkaloid compared to the research volume with pancratistatin. We have published several fully synthetic approaches to C-7 and C-10 analogues, namely compounds 3, 4, and 5, shown in Figure 1 [30][31][32][33]. Only one of these, 10-azanarciclasine (4), displayed activity comparable to the natural product. ...

... Morphine is an NP extracted from the milk of the poppy plant (Papaver somniferum) [53]. This plant is a perennial herb mainly found in the Mediterranean region and some parts of Asia. ...

... 29 In 2021, Thomson and co-workers synthesized 1,5,8trimethoxy-1H-isochromene-3-carboxylate through a seven-step reaction in the presence of a palladium catalyst. 30 Also in 2021, Chen and co-workers prepared a 1-cyano isochromene compound easily with high efficiency by using 1-methoxy-1Hisochromene and trimethylsilyl cyanide in the presence of Fe(OTf) 3 catalyst. 31 In continuation of the ongoing work by our team on catalytic reactions, 32,33 the purpose of this research was to create a novel catalyst with high reactivity through a simple procedure. ...

... Dearomatizations are strategic transformations for assembling complex cyclic, bridged, or spirocyclic scaffolds because multiple bonds are forged from readily available aromatics (1) [2][3][4] . Numerous dearomatizations have featured as key steps in the synthesis of prized bioactive targets [5][6][7][8][9] where brevity is paramount, such as in the syntheses of the anti-viral drug oseltamivir (Tamiflu, 2) 10 and the pain management opiate oxycodone (3) 11 (Fig. 1). ...

... Capitulating to the mob, the journal retracted the paper (Kramer, 2020). It can still be found online (Hudlicky, 2020). As with Gilley's article, there was no data fraud or error because there was no original data. ...

... A reflection on the current state of affairs". 24 This contribution is a self-described "essay", which was commemorative in nature, celebrating Prof. Dieter Seebach on the 30th anniversary of the publication of a review of similar name. 25 According to editorial staff at Angewandte Chemie, Hudlický's essay was peer reviewed. ...

... Other metals such as Pd [19][20][21][22], Ru [23], Au [24][25][26][27], Ag [28][29][30], Cu [31,32], and electrophiles have then been engaged, and two pathways have been identified depending on the nature of the catalyst, 5-exo-dig and 6-endo-dig, resulting in various cyclic products, with the outcome of the process being mainly dependent on the carbophilic or oxophilic properties of the catalytic species (Scheme 2). Citation: Melot, R.; Michelet, V. Coinage Metal-Catalyzed Asymmetric Reactions of ortho-Alkynylaryl and Heteroaryl Aldehydes and Ketones. ...

... 2019年, Hudlicky课题组 [41] 发表了calyciphylline A- 图 2 Stockdill课题组 [40] 对于ABC三环骨架的合成研究 Figure 2 Synthesis of the ABC tricyclic ring system by the Stockdill group [40] 图 3 Bonjoch课题组 [38] 对于ABC三环骨架的合成研究 Figure 3 Synthesis of ABC tricyclic ring system by the Bonjoch group [38] 评 述 2 Himalensine A的ABCD四环骨架合成 研究 2017年, Bonjoch课题组 [39] 报道了himalensine A中 ABCD四环骨架的合成(图5 [39] 对于ABCD四环骨架的合成研究 Figure 5 Synthesis of ABCD tetracyclic ring system by the Bonjoch group [39] 图 6 Dixon课题组 [36] 对于(−)-himalensine A的全合成 Figure 6 Total synthesis of (−)-himalensine A by the Dixon group [36] [42] . 该工作为复杂虎皮楠生物碱 的全合成提供了新颖的策略思路. ...