Tohru Kobayashi's research while affiliated with National Center for Child Health and Development and other places
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Publications (135)
b> Introduction: A feature of the management of extremely preterm infants in Japan is proactive circulatory management using early routine echocardiography performed by neonatologists. Methods: This study was a post hoc analysis of the Patent ductus arteriosus and Left Atrial Size Evaluation in preterm infants (PLASE) study, which is a prospective...
Aim
The present study aimed to estimate the total numbers of obstetric diseases diagnosed, total amounts of medical expenses claimed for obstetric diseases, their averages per livebirth, and yearly trends in Japan.
Methods
This is a secondary analysis of the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) (...
Importance
Kawasaki disease is an acute systemic vasculitis that primarily affects infants and young children. No reproducible risk factors have yet been identified, but a possible association between maternal folic acid supplementation and Kawasaki disease has been reported previously.
Objective
To investigate the associations of exposure to mate...
Background
Many prenatal factors are reported to be associated with congenital heart defects (CHD) in offspring. However, these associations have not been adequately examined using large‐scale birth cohorts.
Methods and Results
We evaluated a data set of the Japan Environmental and Children's Study. The primary outcome was a diagnosis of CHD by ag...
Background:
Neurological impairment is not rare in infants with acute liver failure (ALF). This study aimed to investigate the perioperative risk factors for neurological impairment following liver transplantation (LT) in infantile ALF.
Methods:
Retrospective analysis was performed in infants who were younger than 1 year with ALF who subsequentl...
Background:
Early-onset atopic dermatitis is a strong risk factor for food allergy, suggesting that early effective treatment may prevent transcutaneous sensitization.
Objective:
We tested whether enhanced treatment of atopic dermatitis to clinically affected and unaffected skin is more effective in preventing hen's egg allergy than reactive tre...
Background
Coronary arterial aneurysms (CAAs) associated with Kawasaki disease (KD) significantly affect prognosis. However, the clinical course of CAAs and factors associated with CAA regression have not been well analyzed.
Methods and Results
The cohort of the Z‐Score 2nd Project Stage study, a multicenter, retrospective, cohort study involving...
Background:
Kawasaki disease (KD) is an acute systemic vasculitis (inflammation of the blood vessels) that mainly affects children. Symptoms include fever, chapped lips, strawberry tongue, red eyes (bulbar conjunctival injection), rash, redness, swollen hands and feet or skin peeling; and enlarged cervical lymph nodes. High fevers and systemic inf...
Background
Physiological skin properties of neonates and infants change drastically after birth and are implicated in the onset of atopic dermatitis and other diseases. Studies have measured physiological skin properties in infants; however, how these properties change over time remains unclear. No reports have measured ceramide in the stratum corn...
The long-term prognosis of patients with Kawasaki disease (KD) complicated by coronary artery aneurysms (CAA) is still unclear. The present, multicenter registry study aimed to study the factors associated with coronary events (CE) and determine an appropriate management method for patients with KD complicated with CAA. Patients with KD with onset...
The influence of family allergic history on food allergy in offspring in Japan is unknown. We analyzed data from a nationwide birth cohort study using logistic regression models to examine the associations of maternal, paternal, and both parental histories of allergic diseases (food allergy, atopic dermatitis, asthma, and rhinitis) with their child...
Background: Balloon atrial septostomy (BAS) is an essential catheterization procedure for congenital heart lesions. Recently, a balloon catheter for static BAS was approved for the first time in Japan as an alternative to the conventional pull-through BAS. Despite the expected increase in the use of static BAS, reports on its safety are scarce worl...
Objectives:
In the present study, we aimed to determine the changes in the administration rate of benzodiazepines for pediatric patients with suspected nonconvulsive status epilepticus (NCSE) before and after the introduction of simplified electroencephalography (sEEG) in the emergency department.
Methods:
This retrospective cohort study include...
The remote prognosis of patients with Kawasaki disease (KD) complicated by coronary artery aneurysms (CAA) is still unclear. The present, multicentric registry study aimed to study the factors associated with coronary events (CE) and determine an appropriate management method for patients with KD complicated with medium-sized or large CAA from 2015...
Recent advances in genome editing technology are accompanied by increasing public expectations on its potential clinical application, but there are still scientific, ethical, and social considerations that require resolution. In Japan, discussions pertaining to the clinical use of genome editing in human embryos are underway. However, understanding...
Background
Atopic dermatitis (AD) is a chronic and inflammatory skin disease that causes health-related burdens associated with pruritus and poor quality of life. Our previous study demonstrated that moisturizer (2e) application has a primary preventive effect on AD. However, this effect was not observed in recent randomized control trials. Thus, t...
The effects of allogeneic hematopoietic stem cell transplantation (allo‐HSCT) on systemic chronic active Epstein–Barr virus infection (sCAEBV) are yet to be analyzed in a large number of patients. Using the Japanese registry database, Transplant Registry Unification Management Program, we investigated the outcomes of 102 sCAEBV patients who underwe...
Background:
Although overall survival of ALF has improved, neurological restoration after recovery from ALF may not always be satisfactory. The purpose of this study was to investigate the occurrence and possible causes of NI in children with ALF following LT.
Methods:
We retrospectively examined all children younger than 16 years old with ALF w...
Background
The role of antibiotics in the treatment of Shiga toxin-producing Escherichia coli (STEC) infection is controversial.
Objectives
To evaluate the association between treatment (antibiotics, antidiarrheal agents, and probiotics) for STEC infection and hemolytic uremic syndrome (HUS) development.
Patients and methods
We performed a popula...
Background
Kawasaki disease (KD) is a systemic vasculitis complicated with coronary artery abnormalities (CAAs). Intravenous immunoglobulin reduces the occurrence of CAAs, but significant number of KD patients with CAAs still exists. Thus, new approaches to prevent and attenuate CAAs are warranted. Atorvastatin has been shown to promote endothelial...
Background and aims
Systemic chronic active Epstein-Barr virus infection (sCAEBV) is classified as T- or NK-cell neoplasms in the WHO classification revised in 2017. Although allogeneic stem cell transplantation (allo-HSCT) is efficacious for sCAEBV, the effects are yet to be analyzed in a large number of cases due to the disease rarity. To investi...
Background: Kawasaki disease (KD) is a form of self-limiting vasculitis that causes coronary artery abnormalities in children. Although clinical trials of monoclonal antibodies and anti-cytokine biologics that block cytokine cascades have been conducted, the studies have revealed contradictory results. To examine the effectiveness of treatment with...
Background
There is inconsistent evidence suggesting the clinical relevance of the early detection of future needs of preterm patent ductus arteriosus (PDA) surgery. We tested the hypothesis that echocardiographic indices at 3 days of age predict the future need for PDA surgery.
Methods
We analyzed a database including the clinical and echocardiog...
Kawasaki disease (KD) is an acute systemic vasculitis that mainly affects infants and young children. The etiology of KD has been discussed for several decades; however, no reproducible risk factors have yet been proven. We used the Japan Environment and Children’s Study data to explore the association between the causal effects of exposure during...
Objectives
To test the performance of the Son risk score which was created to predict coronary artery abnormalities from baseline variables in North American patients with Kawasaki disease.
Study design
The dataset from Post RAISE, the largest prospective cohort study of Japanese patients with Kawasaki disease to date, was used for the present stu...
A correction to this paper has been published: https://doi.org/10.1007/s00380-021-01882-3
Recently, targeted therapy has been developed for idiopathic pulmonary arterial hypertension (IPAH). Studies evaluating the prognosis of IPAH have been conducted in adults. However, there is no nationwide survey of pediatric patients with IPAH regarding the long-term prognosis in Japan. Therefore, we investigated the clinical outcomes of Japanese p...
Background:Stent implantation for vascular stenosis associated with congenital heart diseases is commonly performed as an off-label procedure in Japan because there is no officially approved stent for any congenital heart disease.
Methods and Results:We analyzed data from the Japanese Society of Congenital Interventional Cardiology Registry collect...
Background
Examining the predictors of summative assessment performance is important for improving educational programs and structuring appropriate learning environments for trainees. However, predictors of certification examination performance in pediatric postgraduate education have not been comprehensively investigated in Japan.
Methods
The Ped...
Background:In Japan, the choice of pediatric medical devices is limited because of 2 “device lag” problems: Japan lags behind the USA and Europe in device development, and development of pediatric devices lags behind that of adult devices. We aimed to identify the problems with and impediments to pediatric medical device development as recognized b...
Background
The role of therapeutic intervention, particularly antibiotics, for Shiga toxin-producing Escherichia coli (STEC) related infection is controversial.
Methods
We performed a population based matched case-control study to assess the association between treatment (antibiotics, antidiarrheal agents and probiotics) for STEC related infection...
In a meta-analysis of three GWAS for susceptibility to Kawasaki disease (KD) conducted in Japan, Korea, and Taiwan and follow-up studies with a total of 11,265 subjects (3428 cases and 7837 controls), a significantly associated SNV in the immunoglobulin heavy variable gene (IGHV) cluster in 14q33.32 was identified (rs4774175; OR = 1.20, P = 6.0 × 1...
Aims
The associations of 2 nonsynonymous single nucleotide polymorphisms (Arg16Gly and Gln27Glu) in the adrenoceptor β2 (ADRB2) gene with response after albuterol use are conflicting. We conducted a meta‐analysis to examine the cumulative evidence of the effects of these 2 variants on percent forced expiratory volume in 1 second (FEV1.0%) after alb...
Background:Although advances in cardiac surgery have led to an increased number of survivors with congenital heart disease (CHD), epidemiological data regarding the pregnancies and deliveries of patients with repaired CHD are scarce.
Methods and Results:In this study, we retrospectively reviewed the clinical outcomes of pregnancies and deliveries o...
Systemic chronic active Epstein-Barr virus infection (sCAEBV) was defined as a T- or NK-cell neoplasm in the 2017 World Health Organization (WHO) classification. To clarify the clinical features of sCAEBV under this classification and review the effects of chemotherapy, we performed a nationwide survey in Japan from 2016 through 2018 of patients wi...
As a summary of this guideline, Table 21 shows the frequency of each examination, treatment, and lifestyle guidance according to the severity classification of KD. Authors would be pleased if it could be used as a reference for medical staff who handle the remote stage of KD. On the other hand, the higher the severity, the more likely it is that va...
Studies on the effect of cytochrome P450 2C9 (CYP2C9), vitamin K epoxide reductase complex subunit 1 (VKORC1), and cytochrome P450 4F2 (CYP4F2) polymorphisms on warfarin maintenance dose in children are conflicting. We conducted a systematic review and meta-analysis to evaluate the effect of these polymorphisms on warfarin maintenance dose in child...
Objective: Previous studies showed the efficacy of glucocorticoids on prevention of coronary artery lesions (CAL) among Kawasaki disease (KD) patients, and clinical guideline for KD in Japan was changed regarding glucocorticoid use in 2012. However, little is known regarding how the guideline change had impacts on healthcare utilizations and clinic...
Background:
In 2015, infliximab was approved for the treatment of patients with intravenous immunoglobulin-refractory Kawasaki disease (KD) in Japan. However, limited real-world data exist on the usefulness of infliximab for acute KD patients. We conducted a postmarketing surveillance study in patients with acute KD refractory to conventional ther...
Various microorganisms and pathogenic molecules have been reported to cause Kawasaki disease (KD). However, little is known for the key molecules that contribute to the development of coronary arteritis in KD. Using the comprehensive lipidomics in combination with a bioinformatic approach, we demonstrate that the blood levels of oxidized phosphatid...
Aims:
Coronary arteritis is a life-threatening complication that may arise in the acute stage of Kawasaki disease (KD), the leading cause of systemic vasculitis in childhood. Various microorganisms and molecular pathogens have been reported to cause KD. However, little is known about the key molecules that contribute to the development of coronary...
Background:
Albuterol is one of the most frequently used medications in clinical practice and seeing varying responses to albuterol between individuals is not uncommon. Multiple studies have been conducted to investigate the associations of differing responses due to albuterol, particularly with regards to the two nonsynonymous single nucleotide...
Background: Albuterol is one of the most frequently used medications in clinical practice and seeing varying responses to albuterol between individuals is not uncommon. Multiple studies have been conducted to investigate the associations of differing responses due to albuterol, particularly with regards to the two nonsynonymous single nucleotide po...
Background:
Head trauma in children is one of the most common causes for emergency department visits. Although most trauma cases are minor, identifying those patients who have clinically important traumatic brain injury (ciTBI) is challenging. The Pediatric Emergency Care Applied Research Network (PECARN) head trauma prediction rules identifying c...
Objectives:
Cuffed endotracheal tubes are being used increasingly for pediatric patients on mechanical ventilation. Appropriate placement of the tube tip for Microcuff (Kimberley-Clark, Roswell, GA) pediatric endotracheal tube is guided by the intubation depth mark on the device. However, inappropriately deep tip position is sometimes observed dur...
Background: Noncompaction cardiomyopathy is characterized by a left ventricle with a prominent trabecular meshwork. The clinical courses of the growing number of pediatric cases with noncompaction cardiomyopathy remain only partially elucidated.
Methods: We enrolled patients with cardiomyopathies from the database of Specific Pediatric Chronic Dise...
Peripheral blood stem cell transplantation (PBSCT) is being increasingly performed as an alternative to bone marrow transplantation (BMT); however, PBSCT has not been proven to have equivalent outcome to BMT. We conducted a meta-analysis to compare survival rates and treatment-related complications between PBSCT and BMT for pediatric hematologic ma...
Background:
Kawasaki disease (KD) is an acute inflammatory vasculitis (inflammation of the blood vessels) that mainly affects children between six months and five years of age. The vasculitis primarily impacts medium-sized blood vessels, especially in the coronary arteries. In most children, intravenous immunoglobulin (IVIG) and aspirin therapy ra...
Background: Acute coronary syndrome (ACS), which is emerging in adults long after confirmed (followed-up or lost-to-follow), or missed Kawasaki disease (KD), is poorly characterized.
Methods and Results: A Japanese retrospective nationwide hospital-based questionnaire survey of ACS during 2000–09 was conducted to characterize such patients. Among a...
Background:
No echocardiographic indices for predicting the need for preterm patent ductus arteriosus (PDA) surgery have been tested with an adequate sample size. We tested the hypothesis that some echocardiographic indices have better predictive ability for the need for PDA surgery.
Methods:
We prospectively collected data from infants with ges...
Kawasaki disease is an acute systemic vasculitis in children. Antiplatelet medicines are commonly used for Kawasaki disease to attenuate vasculitis and prevent thromboembolism; however, the mechanisms have not been elucidated. The objective of this study is to assess the effectiveness of antiplatelet medications for Kawasaki disease. We used Medlin...
Introduction:
Training in scholarship is an essential component of postgraduate education. Previous studies worldwide on the research activities of pediatric residents were questionnaires targeting program directors or surveys conducted in a limited number of institutions; however, no nationwide studies have been conducted. The objective of this s...
Purpose
The purpose was to establish an estimated fetal weight (EFW) reference for twin pregnancies in Japan and to compare the growth of twins with singletons.
Methods
We retrospectively investigated Japanese women who delivered live-born twins at our center during the period from 2010 to 2016. The main exclusion criteria were monoamniotic twins,...
Background: As a source of cells for hematopoietic cell transplantation (HCT), peripheral blood stem cells (PBSC) have become a major alternative to bone marrow, the most common source of cells. A meta-analysis showed that the use of PBSC in adults is not superior with respect to overall survival, and the incidence of chronic graft-versus-host dise...
Background and aims
Chronic active Epstein-Barr virus infection (CAEBV) is classified into T- or NK-cell neoplasms in the new WHO classification revised in 2017. Allogeneic stem cell transplantation (allo-HSCT) has recently been reported to be an effective treatment for this disorder. Conversely, effects of chemotherapies on CAEBV have not yet been...
Background
Atopic dermatitis is the first clinical manifestation of the atopic march, with the highest incidence in the first year of life. Those affected often go on to develop other allergic diseases including food allergy, asthma, and allergic rhinitis. Recent evidence suggests that sensitization to foods may occur through a defective skin barri...
Importance
Few studies with sufficient statistical power have shown the association of the z score of the coronary arterial internal diameter with coronary events (CE) in patients with Kawasaki disease (KD) with coronary artery aneurysms (CAA).
Objective
To clarify the association of the z score with time-dependent CE occurrence in patients with K...
Kawasaki disease (KD), an acute childhood panvasculitis, presents a variety of ocular complications as well as conjunctival injection among the principal symptoms. However, most pediatricians are unfamiliar with the ophthalmological complications of KD. A 2-year-old girl was referred to us from the ophthalmology department due to injected bulbar co...
Objective:
To assess the safety and efficacy of infliximab (IFX) for the treatment of patients with Kawasaki disease (KD).
Study design:
This was a nationwide survey of 274 Japanese institutions exploring how IFX was used to treat patients with KD. The patients' sex, age, treatment course, pre- and post-IFX therapy blood test results, coronary a...
Background:Giant coronary aneurysm is the most severe sequela in Kawasaki disease, occurring in approximately 0.2% of patients in Japan. Regression is rare, while myocardial infarction (MI) and sudden death are relatively common. Herein, we reviewed patients with giant coronary aneurysm in a 10-year period.
Methods and Results:A nationwide question...
Kawasaki disease (KD) is a systemic vasculitis in infants. In KD, encephalopathy is rarely (0.1%) associated, however, clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) has previously been reported in some pediatric patients. Here, we report on a 2-year-old girl who had KD complicated with MERS. The patient experi...
Background:
Kawasaki disease is an acute vasculitis of childhood that leads to coronary artery aneurysms in ?25% of untreated cases. It has been reported worldwide and is the leading cause of acquired heart disease in children in developed countries.
Methods and results:
To revise the previous American Heart Association guidelines, a multidiscip...
The standard treatment for Kawasaki disease (KD) is high-dose intravenous immunoglobulin (IVIG). Some patients experienced recurrent fever after IVIG following defervescence. However, little is known about the frequency of such episodes and the clinical outcome for such patients. We classified 195 KD patients into 4 groups based on their fever patt...
There are no specific therapies for Kawasaki disease patients, because the causes of the disease have not been identified. Currently, treatment with intravenous immunoglobulin (2 g/kg single infusion) plus aspirin (30 mg/kg/day) is considered the standard therapy. However, 20 % of patients do not become afebrile despite completion of intravenous im...
In Kawasaki disease (KD), endothelial damage and an elevation in coagulant factors provoke thrombosis. Lupus anticoagulant (LA) is strongly associated with the risk of thrombosis in patients with antiphospholipid syndrome; however, there has been no report of positive LA in KD patients. A previously healthy, 2-year-old boy was admitted due to fever...
Previous chapters described initial and rescue treatment for patients with Kawasaki disease. Other immunosuppressive agents, such as biological agents, methotrexate, cyclophosphamide, and plasma exchange, may also be effective for patients with Kawasaki disease. However, most of these agents have not been carefully evaluated for their efficacy in s...
Background: Infliximab (IFX) therapy is increasingly used in the treatment of intravenous immunoglobulin (IVIG)-resistant patients with Kawasaki disease (KD).
Purpose: To analyze the effects and safety of IFX therapy in IVIG-resistant patients with KD.
Methods: Fifty-five patients who were administered IFX after initial IVIG between December 2008 a...
Several scoring systems have been developed to predict formation of coronary artery lesions in patients with Kawasaki disease. The initial objective of such scoring systems was to identify indications for cardiac catheterization and intravenous immunoglobulin treatment. Currently, the objective is to predict response to initial intravenous immunogl...
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the benefits and harms of using TNF-α blockers (i.e. infliximab and etanercept) to treat children with Kawasaki disease. © 2016 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Objectives:
The Pediatric Emergency Care Applied Research Network (PECARN) head trauma prediction rules are used to assist computed tomography (CT) decision-making for children with minor head trauma. Although the PECARN rules have been validated in North America and Europe, they have not yet been validated in Asia. In Japan, there are no clinical...
To obtain the risk estimates of autism spectrum disorder (ASD) in the offspring exposed to serotonin reuptake inhibitors (SSRI) in utero, we performed systematic review and meta-analysis of relevant studies. Five case-control and three cohort studies were eligible for the analysis. The SSRI group had significantly higher risk of ASD than the SSRI n...
Background
Despite its shortcomings, warfarin is still the most commonly prescribed anticoagulant to prevent thromboembolism in children. In adults, numerous studies confirmed the robust relationship between warfarin maintenance doses and single nucleotide polymorphisms of cytochrome P450 2C9 (CYP2C9), vitamin K epoxide reductase (VKORC1), and cyto...
Background:
Several coronary artery Z-score models have been developed. However, a Z-score model derived by the lambda-mu-sigma (LMS) method has not been established.
Methods:
Echocardiographic measurements of the proximal right coronary artery, left main coronary artery, proximal left anterior descending coronary artery, and proximal left circu...
Background
Kawasaki disease (KD) is a form of self-limiting vasculitis that causes coronary artery abnormality in children. Based on reports of elevated plasma level of cytokines such as tumor necrosis factor-α in KD patients, clinical trials of monoclonal antibodies that block cytokine cascades have been conducted. However, the studies have reveal...
A diagram of ORAI1 four trans-membrane protein and the positions of the three variants affecting ORAI1 protein sequence.
(PDF)
Prediction of impact of the amino acid sequence alterations on ORAI1 function.
(PDF)
Association results of the SNPs tagged by rs3741596 with KD.
(XLS)
Kawasaki disease (KD; MIM#61175) is a systemic vasculitis syndrome with unknown etiology which predominantly affects infants and children. Recent findings of susceptibility genes for KD suggest possible involvement of the Ca2+/NFAT pathway in the pathogenesis of KD. ORAI1 is a Ca2+ release activated Ca2+ (CRAC) channel mediating store-operated Ca2+...
Haplotypes and genotype combinations with two associated variants of the ORAI1 gene in this study.
(PDF)
List of the identified variants.
(XLS)
Distribution of rs3741596 alleles in HapMap populations.
(PDF)
Association result of the c.59G>C variant of ORAI1 gene with KD.
(XLS)
miRNAs which bind differently to the surrounding sequences of the 3'-UTR SNPs tagged with rs3741596
(XLS)
Frequencies and positions of the group of variants tagged by rs3741596.
(XLS)
Recent reports described the NUP98-NSD1 fusion as an adverse prognostic marker for acute myeloid leukaemia (AML) and PRDM16 (also known as MEL1) as the representative overexpressed gene in patients harbouring NUP98-NSD1 fusion. PRDM16 gene expression levels were measured via real-time polymerase chain reaction in 369 paediatric patients with de nov...
Introduction: The severity of coronary artery aneurysms (CAA) in patients with Kawasaki disease (KD) has been recently classified according to the z-score. However, it is not known whether this classification can predict coronary events such as stenosis, obstruction, and thrombosis.
Methods: In this multicenter retrospective study, data on height,...
Despite extensive research efforts over decades, the teratogenic profile of valproic acid (VPA) remains obscure. We performed cumulative and conventional meta-analyses of cohort studies to determine the time profiles of signal emergence of VPA-associated congenital malformations (CMs) and to define risk estimates of each of the CMs. Fifty nine stud...
Backgrounds: In Japan, infliximab (IFX) has been used in patients with Kawasaki disease (KD) who did not respond to initial treatment. However, nationwide surveillance of the IFX for KD patients has not been reported. The objective of the present study is to reveal epidemiological and clinical features of KD patients treated with IFX.
Method: This...
Background: In Japan, 2 guidelines are published, the clinical guidelines for medical treatment of acute stage Kawasaki disease(KD)(2012) and guidelines for diagnosis and management of cardiovascular sequelae in KD(2013). Patient Condition Adaptive Path System (PCAPS) is a technique to structure clinical knowledge. It places “patient condition” as...
Kawasaki disease (KD; MIM611775) is a systemic vasculitis syndrome with unknown etiology which predominantly affects infants and children. Recent findings of susceptibility genes for KD have suggested up-regulation of Ca2+/NFAT pathway as one of the main pathophysiological processes in KD. In this study, we focused on ORAI1, a gene for a channel in...
Backgrounds and Objectives: RAISE protocol demonstrated that IVIG plus prednisolone (PSL) therapy reduced the incidence of coronary artery abnormalities (CAAs) in children with high risk of refractory Kawasaki disease (KD). However, this protocol has longer hospital stay because PSL is tapered over the next 15 days when CRP was under 5mg/L. We prop...
Background: Although RAISE study demonstrated that intravenous immunoglobulins (IVIG) plus prednisolone (PSL) therapy for refractory Kawasaki disease (KD) reduced coronary artery aneurysm, the study population included a few incomplete KD. The aim of study was to evaluate the efficacy of RAISE protocol for incomplete KD.
Methods: Children with inco...
Background and Objective: Long term prognosis of Kawasaki disease (KD) with giant aneurysm is not yet well understood. We conducted a nationwide survey of KD with giant aneurysm for recent 10 years, and analyzed cardiac events of those patients.
Methods: Nationwide epidemiological survey of KD has been conducted every 2 years since 1970 in Japan. W...
Background: Sporadic cases of acute coronary syndrome (ACS) have been reported in adults with coronary sequelae presumably due to Kawasaki disease (KD). However, ACS in adults with a confirmed (whether followed-up or lost to follow-up) as well as unconfirmed history of KD is poorly characterized. Methods: To investigate ACS in such adults after KD...
Objective
Cough is so common that the best method for evaluating nocturnal cough in children is required.Methods
We developed a cough monitoring system by evaluating 50 child volunteers, and validated the cough monitor in 20 samples from 10 children with cough overnight. Coughs were recorded using a video camera and digital sound recording. At the...
Approximately one decade has passed when the original version of "Guidelines for Medi cal Treatment of Acute Kawasaki Disease" was published. Since then, many clinical stud ies have investigated and new evidences regarding diagnosis and acute phase treatment have been piled up. Based upon the background, Research Committee of the Japanese Society o...
Citations
... In our recent review [122], RCTs evaluating food sensitisation and food allergy prevention through skin intervention included trials using moisturizers in eight studies [75,115,[123][124][125][126][127], a nonsteroidal topical agent (pimecrolimus) in one study [128] and our PACI study [129,130] using a subclinical inflammationtargeted proactive treatment with betamethasone valerate (Potent in the UK and Medium in the USA) for body. All clinical trials [75,115,[123][124][125][126][127] by moisturizer application could not reduce food allergy onset. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281247269711-1716740100997_Q64/Kiwako-Yamamoto-Hanada.jpg)
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... Once CAAs have developed, they remain without regression in about 30% of the cases, and persistent CAAs pose a life-long risk of thrombosis beyond childhood. 1,2 Flow turbulence in cavernous CAAs is thought to cause the thrombosis, but atherosclerotic changes in the vessel walls have been reported in the convalescent phase of Kawasaki disease and they might also contribute to the cardiovascular events. 3 Given the rise in newly diagnosed cases of Kawasaki disease, there is presumably a substantial number of adult patients who carry these pathological conditions, which could be an issue when following and treating adult patients with a history of Kawasaki disease. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/273842077696000-1442300447241_Q64/Masaru-Miura.jpg)
... 9 A recent meta-analysis comparing different IVIG infusion regimens in patients with Kawasaki disease found that high-dose IVIG regimens are likely to be more effective and may even reduce the need for additional treatment compared to medium-or low-dose IVIG regimens, with little or no difference in the number of adverse events between groups. 10 We decided to test whether the higher IVIG dose would not be more effective in patients with NS. We started with 250 mg/kg/day for 3 days or 750 mg/kg/month administration and have not observed any adverse effects so far. ...
... Water content; levels of NMF, ceramide, cholesterol, and lactic acid; and SC thickness were estimated using a confocal Raman spectrometer (CRS; Model 3510 Skin Composition Analyzer; RiverD B.V., Rotterdam, The Netherlands). Transepidermal water loss (TEWL) and SC hydration were measured using a Tewameter (TM300; Courage + Khazaka electronic GmbH, Köln, Germany) and Corneometer (CM 825; Courage + Khazaka electronic GmbH), as previously reported [25]. Measurements were performed at 0 (1-7 days old), 1 (±14 days), 2 (+1 month), 6 (5-10 months), and 12 (11-24 months) months ( Figure 1). ...
... 29 The initial decreased shear stress and disturbed blood flow pattern are responsible for the CAA sequelae. 30 These results underscore the importance of early echocardiography in KD management. ...
... Risk factors for the development of AD during the first 2 years of life were maternal and paternal history of AD, while wheezing bronchitis was mostly associated with a maternal history of asthma [46]. There is evidence for parental history playing an important role in the development of both inhalant and food allergies of offspring from infancy to childhood, with multiple food sensitizations being more frequent among children with a parental history of allergic rhinitis [48,62,63]. Maternal allergic disorders were significant risk factors for allergic diseases in early childhood, and maternal asthma was found to result in a threefold higher asthma risk in children [57,58]. ...
... If difficulties are to be encountered or the child is older than 6-8 weeks and has thickened septum, static balloon atrial dilation and cutting balloon or blade septostomy should be considered. 2,5,6 Here, we report and describe an improvised technique for rescue atrioseptostomy, in unusual circumstances, where the FDAapproved atrioseptostomy balloon catheters were not available in our institution due to international shortage. It can be debated that static atrial septostomy using a 9 mm balloon for a 3.5 kg term baby is too small. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/331469374410771-1456039865542_Q64/Hikoro-Matsui.jpg)
... Much research examining public attitudes about gene editing in the medical field has focused on which medical changes are acceptable to the public and the demographic characteristics associated with opinions. In general, results from public opinion research indicate support for therapeutic uses of gene-edited and aversion for non-disease uses that are cosmetic or otherwise alter physical characteristics (Gaskell et al., 2017;Treleaven and Tuch, 2018;Critchley et al., 2019;McCaughey et al., 2019;Jedwab et al., 2020;Watanabe et al., 2020;McFadden et al., 2021a;Kobayashi et al., 2022). ...
... We showed emollient applications were associated with asthma [73]. We also showed twice-daily emollients increased eczema onset compared with once-daily applications by the PAF study [74,75]. ...
... In another study, the 3-year OS rates for patients treated using chemotherapy followed by HSCT and those treated using HSCT only were 65% and 82%, respectively [21]. In a recent study conducted using the Japanese registry database Transplant Registry Unification Management Program (TRUMP), the 3-year OS rate for patients with CAEBV who underwent HSCT (median age, 21 years) was 72.5% [54]. Age (≥ 15 years), disease activity, elevated soluble interleukin-2 receptor level, and conditioning without radiotherapy are independently associated with poor survival. ...
