Tobias Runge's scientific contributions

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Publications (3)

ULTRASMALL PARTICLES OF IRON OXIDE ENHANCED MR-IMAGING OF ISCHEMIC ACUTE RENAL FAILURE AND CYCLOSPORINE NEPHROTOXICITY IN A RAT MODEL ON A CLINICAL 3T SCANNER
  • Article

October 2014

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13 Reads

Transplant International

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T. Runge

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U. Attenberger

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[...]

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U. Goettmann
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Ultrasmall Particles of Iron Oxide-enhanced MR Imaging of Ischemic Acute Renal Failure in a Rat Model on a Clinical 3 T Scanner

December 2011

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5 Reads

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Tobias Runge

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[...]

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Uwe Gottmann

PURPOSE To assess if the novel ultrasmall particle of iron oxide (P904) can be used to visualize ischemic acute renal failure (IARF) in a rat model. METHOD AND MATERIALS In this IRB approved study 6 Lewis-rats were subjected to 45 minutes unilateral ischemia. After 36 h the rats were injected 516 µmol/kg P904 (Guerbet) and MR-imaging was performed another 36h after the P904-injection. Imaging was performed on a clinical 3T scanner (Siemens TimTrio) with a dedicated 8-element rat coil (Rapid) with T2w-TSE sequences in coronal (TR/TE 2000/114ms, acquisition time 2:33min) and axial (3090/115ms, 3:47min) orientation with identical acquired spatial resolution of 0.3x0.3x1.0mm³. Signal to noise measurements (SNR) were performed in the cortex, medulla and pyelon of the IARF-kidney and the contralateral kidney which served as internal control. Immediately after the MR-exam the rats were sacrificed and histology was assessed as gold standard including Perl´s Prussian blue staining to demonstrate iron (i.e. P904) and ED-1 immunohistochemistry to detect rat macrophages. RESULTS Apparent visual differences between the IARF-kidneys and controls were encountered. Signal decay was mainly seen in the medulla of the IARF kidneys. The SNR of the IARF vs. control were: cortex 20.0 vs.10.9 (p=0.007), medulla 7.2 vs. 18.9 (p<0.001) and pyelon 17.1 vs. 28.3 (p=0.03). In all IARF-kidneys the histology confirmed the predominantly medullary presence of abundant iron and ED1-positive macrophages (50.5 vs. 4.7 per high power field, p<0.001) in conjunction with typical changes of IARF while being normal in the control group. CONCLUSION P904 seems to be a suitable contrast agent to non-invasively detect IARF in a rat model with good correlation to histology. This suggests that P904-enhanced MR-imaging holds promise for non-invasive assessment of inflammatory renal diseases. CLINICAL RELEVANCE/APPLICATION USPIO-enhanced functional MR-imaging appears to be a promising tool to non-invasively detect inflammatory renal diseases.

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