Timofei Grigoriev's research while affiliated with Moscow Institute of Physics and Technology and other places
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Publications (16)
High-strength composite hydrogels based on collagen or chitosan–genipin were obtained via mixing using highly porous polylactide (PLA) microparticles with diameters of 50–75 µm and porosity values of over 98%. The elastic modulus of hydrogels depended on the filler concentration. The modulus increased from 80 kPa to 400–600 kPa at a concentration o...
The paper proposed a new porous material for wound healing based on chitosan and C-phycocyanin (C-PC). In this work, C-PC was extracted from the cyanobacteria Arthrospira platensis biomass and purified through ammonium sulfate precipitation. The obtained C-PC with a purity index (PI) of 3.36 ± 0.24 was loaded into a chitosan sponge from aqueous sol...
Pharmaceuticals including antibiotics are among the hazardous micropollutants (HMP) of the environment. Incomplete degradation of the HMP leads to their persistence in water bodies causing a plethora of deleterious effects. Conventional wastewater treatment cannot remove HMP completely and a promising alternative comprises biotechnologies based on...
Pharmaceuticals including antibiotics are among hazardous micropollutants (HMP) of the environment. Incomplete degradation of the HMP leads to their persistence in water bodies causing a plethora of deleterious effects. Conventional wastewater treatment cannot remove HMP completely, and a promising alternative is comprised by biotechnologies based...
Restoring the anatomical and functional characteristics of the cornea using various bioma- terials is especially relevant in the context of a global shortage of donor tissue. Such biomaterials must be biocompatible, strong, and transparent. Here, we report a Viscoll collagen membrane with mechanical and optical properties suitable for replacing dam...
The fibrous porous structure of polymers can mimic the extracellular matrix of the native tissue, therefore such polymers have a good potential for use in regenerative medicine. Organs and tissues within the body exhibit different mechanical properties depending on their functionality, thus artificial scaffolds should have mechanical behaviors simi...
Highly porous polymer materials have been studied a lot for applications in biotechnology and biomedicine, because of their high surface area and percolated pore structure. Varying processing conditions, in this study, can tune the morphology, mechanical, and physicochemical characteristics of the materials. In the present work, cross‐linked poly(v...
Restoring the anatomical and functional characteristics of the cornea with the help of various biomaterials is relevant, especially in the context of a global shortage of donor tissue. Such biomaterials must be biocompatible, strong, and transparent. Here, we report a Viscoll collagen membrane with mechanical and optical properties suitable for rep...
The possibility of creating a biofuel cell based on a metal stent was shown in this study. Given the existing stent implantation approaches, the integration of a biofuel cell into a stent naturally entails capacity for biofuel cells to be installed into a human body. As a counter electrode, a hydrogel based on iota-carrageenan, polyvinyl alcohol, a...
In dentistry, maxillofacial surgery, traumatology, and orthopedics, there is a need to use osteoplastic materials that have not only osteoinductive and osteoconductive properties but are also convenient for use. In the study, compositions based on collagen hydrogel were developed. Polylactide granules (PLA) or a traditional bone graft, a mixture of...
Collagen's unique properties are ideal for creating tissue and organ equivalents. Rapid development of methods for creating such objects has revealed that collagen biomaterials have poor mechanical properties, which complicates their use. A potential solution is increasing the collagen concentration in the initial solution; however, there is little...
Wound healing is a complex set of body responses to damaged tissues, which manifests itself through local destructive-inflammatory changes and general reactions. There are numerous coatings used currently in clinical practice to treat wounds. These coatings serve to develop a wet anti-bacterial environment, which is essential to facilitate the heal...
Although collagen based materials are widely used in corneal tissue engineering with promising results. The usage of such materials for the improvement of corneal biomechanical properties is still unclear. In this study, we aimed to investigate a new Viscoll collagen-based membrane for the improvement of corneal biomechanical characteristics.The ri...
In this work, the high‐frequency acoustic microscopy is applied for imaging of internal microstructure and measurement of elastic characteristics of the biodegradable polymers based on D,L‐lactide, L‐lactide, ε‐caprolactone, and their copolymers. Acoustic microscopy results (images of microstructure in the volume and values of sound speed) have bee...
Citations
... Crude C-PC was extracted from pretreated (threefold freezing/thawing cycle) wet biomass, as described in [44]. The C-PC crude extracts were purified via ammonium sulfate precipitation. ...
... Examples include plastic biodegradation by adhesion on cell surface with following enzymatic hydrolysis; this process is extensively studied with the focus on the enzymes polyethylene hydrolase (PETase) and mono(2hydroxyethyl) terephthalic acid hydrolase (MHETase) (Chia et al. 2020). Other examples include heavy metal phycoremediation by their uptake by and enzymatic reduction (e.g., by chromium reductase) in the microalgal cells (Priya et al. 2022), and xenobiotics degradation Ovis-Sánchez et al. 2023;Vasilieva et al. 2023) e.g., by nitrilase (Vingiani et al. 2019). ...
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... The cornea was preserved throughout and was of uni form thickness, with no visible changes throughout its thickness. The study suggests tha collagen-based hydrogel has potential as an artificial stroma equivalent for corneal strom regeneration, with promising results in terms of biocompatibility and integration into th corneal stroma [106] (Figure 5). The studies underscore the promising prospects of colla gen-based hydrogels for corneal regeneration applications. ...
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... Such materials are characterized by their polymer composition, sponge-wall thickness, degree of porosity, and orientation. All of the above can significantly affect the mechanical properties of the material and the survival rate of scaffolds in a living organism [7,8]. To improve biocompatibility, as well as regulate the physical-chemical and mechanical properties, modification of scaffolds with solutions of biopolymers, such as collagen and chitosan, is used [9]. ...
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... [52] While PB is widely employed as a very well-working substance with "artificial peroxidase" activity that also participates in electron transfer [46], others can also be used. Examples include carbon-based materials such as CNT, MWCNT, graphene oxide, graphite, and conducting polymers, such as PEDOT:PSS [53,54]. ...
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... In our previous study [18], we demonstrated that collagen hydrogels prepared from a concentrated solution of type I collagen met the majority of these criteria. However, the ability of cells within such a carrier to exert a clinically relevant effect in vivo has not been investigated. ...
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... Образец РП, использованный в качестве матрицыносителя и условно обозначенный как «Chitosan-soft» (Ch-S), обладал следующими параметрами: степень пористости 98%, толщина стенок 600-1200 нм, размер пор 70-200 мкм, деформация при сжатии 50,14%, модуль текучести -0,369 МПа, условный предел текучести -24,15 кПа. Эффективность данной лекарственной формы была экспериментально подтверждена в ходе предшествующих доклинических испытаний по разработке биополимерных РП на основе хитозана [4,5]. Выбранные для исследования антисептики отличались механизмом противомикробного действия и избирательностью влияния на различные компоненты бактериальной клетки. ...
... Biomaterials serve dual purposes in both clinical and experimental contexts (19)(20)(21)(22). ...
