Teruo Amagasa's research while affiliated with Tokyo Medical and Dental University and other places

Publications (399)

Article
This clinico-statistical study includes 597 cases of oral squamous cell carcinoma treated at the Maxillofacial Surgery Section of Tokyo Medical and Dental University between January 2002 and December 2011. There were 373 male and 224 female patients (male to female ratio, 1.7 : 1), and the median age was 67 years. The tongue (53.3%) was the most co...
Article
We examined the usefulness of a double-staining method using iodine solutions of different concentrations for the excision of T1, T2 squamous cell carcinomas (SCCs) of the tongue. We studied 127 patients who were given a diagnosis of T1, T2 SCCs of the tongue at Maxillofacial Surgery, Tokyo Medical and Dental University from 2000 through 2010. The...
Chapter
At a World Health Organization workshop held in 2005, the term “oral potentially malignant disorders” (OPMDs) was recommended instead of “premalignant lesions and conditions.” This chapter describes two OPMDs, namely, oral leukoplakia and erythroplakia. Oral leukoplakia is a newly defined entity of white plaques of questionable risk after excluding...
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Full-text available
We examined the changes in psychological distress and quality of life (QOL) during the perioperative period in oral cancer patients undergoing surgery and investigated the relationship between patient's psychological distress and QOL. Methods. Fifty patients participated. The Hospital Anxiety and Depression Scale (HADS; Japanese version), as a psyc...
Article
The purpose of this study was to evaluate the stability and viability of mandibular bone regeneration using a poly(l-lactide) (PLLA) mesh and autogenous particulate cancellous bone and marrow (PCBM). Sixty-two procedures were undertaken at eight hospitals (22 malignant tumours, 30 benign tumours, five cysts, two osteomyelitis, two trauma, and one a...
Article
Oral carcinogenesis is a complex process involving multiple genes. However, the genetic changes involved in this process are not apparent in identical oral squamous cell carcinomas (OSCCs). According to pathological characteristics, samples of normal tissue, oral dysplastic lesions (ODLs), and invasive cancers were obtained from identical OSCCs usi...
Article
The incidence and mortality statistics for oral squamous cell carcinoma (OSCC) were 10th and 12th, respectively, in human cancers diagnosed worldwide in 2008. In this study, to identify novel tumor-suppressive microRNAs (TS-miRNAs) and their direct targets in OSCC, we performed methylation-based screening for 43 miRNAs encoded by 46 miRNA genes loc...
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Bone development is a dynamic process that requires cell motility and morphological adaptation under the control of actin cytoskeleton. This actin cytoskeleton system is regulated by critical modulators including actin-binding proteins. Among them, profilin1 (Pfn1) is a key player to control actin fiber structure, and it is involved in a number of...
Article
To explore the mechanism of bone destruction associated with oral cancer, we identified factors that stimulate osteoclastic bone resorption in oral squamous cell carcinoma. Two clonal cell lines, HSC3-C13 and HSC3-C17, were isolated from the maternal oral cancer cell line, HSC3. The conditioned medium from HSC3-C13 cells showed the highest inductio...
Article
Confocal immunofluorescence tiling imaging revealed the spatio-temporal distributions of osterix and sclerostin in femurs from 3-day-old, 2-week-old and 4-week-old rats to be reciprocally exclusive at the tissue level. Further quantitative three-dimensional immuno fluorescence morphometry demonstrated the increasing distribution of sclerostin in th...
Article
Tumor metastasis to bone is a serious pathological situation that causes severe pain, and deterioration in locomoter function. However, the mechanisms underlying tumor metastasis is still incompletely understood. CIZ/NMP4 is a nucleocytoplasmic shuttling protein and its roles in tumor cells have not been known. We, therefore, hypothesized the role...
Article
The epithelial-mesenchymal transition (EMT) plays a crucial role in normal and disease processes including tumor progression. In this study, we first classified epithelial-like and mesenchymal-like oral squamous cell carcinoma (OSCC) cell lines based on expression profiles of typical EMT-related genes using a panel of 18 OSCC cell lines. Then, we p...
Article
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Recently, epithelial-mesenchymal transition (EMT) has been demonstrated to contribute to malignant transformation during cancer progression. To perform the function-based screening of EMT-related microRNAs (miRNAs), we first generated an in vitro model using a pancreatic...
Article
The upper lip is formed by the fusion of facial processes, a process in which many genetic and environmental factors are involved. Embryonic hypoxia is induced by uterine anemia and the administration of vasoconstrictors during pregnancy. To define the relationship between hypoxia and upper lip formation, hypoxic conditions were created in a whole...
Article
Recently an increase in the serum levels of a bone formation marker after anti-tumor necrosis factor (TNF)-α therapy in rheumatoid arthritis patients has been reported. However, there remains no direct evidence that TNF-α antagonist could accelerate bone formation under inflammatory condition. Cavity-induced allosteric modification (CIAM) compound,...
Article
Subapical mandibular surgeries have been used to correct vertical malocclusion and interdental problems associated with mandibular deformity. Subapical surgery to the anterior part of the mandible is applicable in many patients with anterior open bite and deepbite. Surgery of the posterior part of the mandible is needed less frequently than surgery...
Article
In conventional orthognathic surgery, Le Fort I osteotomy (L1), sagittal splitting ramus osteotomy (SSRO), and two-jaw surgery (L1+SSRO) have been used to correct severe reversed occlusion caused by maxillary hypoplasia in patients with cleft lip and palate. However, these methods produce a limited amount of movement for osteotomized jaw bone, and...
Article
Although vascular invasion (VI) is recognized as an important predictor of lymph node metastasis and a significant prognostic factor in head and neck squamous cell carcinoma (HNSCC), there is currently no common definition for the pathological evaluation of VI status. We reviewed the medical records of 63 consecutive resected primary oral tongue SC...
Article
Osteoporosis causes fractures that lead to reduction in the quality of life and it is one of the most prevalent diseases as it affects approximately 10% of the population. One of the important features of osteoporosis is osteopenia. However, its etiology is not fully elucidated. Dok-1 and Dok-2 are adaptor proteins acting downstream of protein tyro...
Article
The purpose of this study was to investigate the detailed oral function and perception (warm, cold, tactile and thermal pain) of the oral mucosa of 10 postoperative mandibular cancer patients. The age of the patients ranged from 59 to 82 years. Oral function was evaluated using the low-adhesive color-developing chewing gum method, the Occlusal Pres...
Article
Bone regeneration therapy based on the delivery of osteogenic factors and/or cells has received a lot of attention in recent years since the discovery of pluripotent stem cells. We reported previously that the implantation of capillary networks engineered ex vivo by the use of cell-printing technology could improve blood perfusion. Here, we develop...
Article
The epithelial-mesenchymal transition (EMT) has a crucial role in normal and disease processes including tumor progression. In this study, we first classified epithelial-like and mesenchymal-like oral squamous cell carcinoma (OSCC) cell lines based on expression profiles of typical EMT-related genes using a panel of 18 OSCC cell lines. Then, we per...
Article
Although epidermal growth factor receptor (EGFR) is particularly important in the pathogenesis of head and neck squamous cell carcinomas (HNSCCs), conflicting data have been reported on the correlation between EGFR copy number and survival and the association between EGFR copy number and protein expression. Anatomical site of the tumour in HNSCCs m...
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Objectives: This study investigated the effects of reclining position on swallowing functions in the patients who had undergone surgery for oral tumors. Subjects and methods: 53 Patients after oral tumor surgery who had undergone the videofluoroscopic swallowing study in the sitting position and reclining position were sampled. We measured Oral...
Article
A clinicopathological study was made of 41 patients with squamous cell carcinoma of the upper gingiva. All patients had been treated at the Maxillofacial Surgery Department of the Tokyo Medical and Dental University hospital, consisting of 15 men and 26 women, mean age 62 years, range 38-85 years. According to the T classification there were 8 case...
Article
Regeneration of bone requires the combination of appropriate drugs and an appropriate delivery system to control cell behavior. However, the delivery of multiple drugs to heal bone is complicated by the availability of carriers. The aim of this study was to explore a new system for delivery of a selective EP4 receptor agonist (EP4A) in combination...
Article
The purpose of this study was to clarify the clinico-pathological findings of Warthin's tumors. Twenty cases of Warthin's tumors treated at our clinic during the past 22 years and their medical charts and imaging films were reviewed. Warthin's tumors occurred more frequently in middle-aged or elderly men than in women. Solitary tumors were signific...
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Extracapsular spread (ECS) of lymph node metastasis in head and neck cancers, including oral squamous cell carcinomas (OSCCs), is known to reflect tumour aggressiveness, and is significantly associated with high rates of loco-regional recurrence, distant metastasis, and poor outcome. The purpose of this study was to confirm ECS as an important prog...
Article
KeywordsOral premalignant lesion–Potentially malignant disorders–Leukoplakia–Erythroplakia–Malignant transformation–Epithelial dysplasia
Article
We investigated the effects of acerogenin A, a natural compound isolated from Acer nikoense Maxim, on osteoblast differentiation by using osteoblastic cells. Acerogenin A stimulated the cell proliferation of MC3T3-E1 osteoblastic cells and RD-C6 osteoblastic cells (Runx2-deficient cell line). It also increased alkaline phosphatase activity in MC3T3...
Article
In this review article, the clinical and histopathological characteristics of oral premalignant lesions, and primarily oral leukoplakia, are noted and the risk factors for malignant transformation of oral leukoplakia are discussed. Malignant transformation rates of oral leukoplakia range from 0.13 to 17.5%. The risk factors of malignant transformat...
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The purpose of this study was to characterize the radiobiological properties of stem/progenitor cells derived from apical papilla-derived cells (APDCs) compared to bulk APDCs. APDCs were isolated from freshly extracted human third molars with immature apices. Multipotent spheres, which are thought to contain an enriched population of stem/progenito...
Article
Keratocystic odontogenic tumor is a cystic lesion that behaves more aggressively than other jaw cysts. One of its characteristic histologic features is a parakeratinized uniform layer of lining epithelium. A jaw cyst lined with orthokeratinized epithelium is called an orthokeratinized odontogenic cyst. These keratinized jaw cysts are thought to be...
Article
Detection thresholds for Semmes-Weinstein monofilaments (SW tester), a 5-Hz rectangular electric stimulus and a warming stimulus were measured in the normal lower lip and chin area of 242 subjects (87 males, 155 females). Differences in terms of the stimulated region, gender and age were examined and the coefficients of variance (CVs) of the thresh...
Article
This study compared dento-facial changes after two-jaw surgery with or without horseshoe osteotomy of the maxilla in mandibular protrusion patients with open bite or long face. Twenty adult patients who underwent orthognathic surgery to correct mandible protrusion were enrolled in this study. The subjects were divided into two groups based on surgi...
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Although chromosomal instability (CIN) has been detected in many kinds of human malignancies by means of various methods, there is no practical assessment for small clinical specimens. In this study, we evaluated CIN in fine-needle aspiration (FNA) biopsied oral squamous cell carcinomas (SCCs) using fluorescence in situ hybridization (FISH) analysi...
Article
Detection thresholds to Semmes-Weinstein monofilaments, 5-Hz rectangular electric stimulation and warming were measured in 38 affected sides of neurosensory disturbance of the lower lip and chin after dental and oral surgery treatment. The ages of the patients ranged from 11 to 72 years. The examination periods were within 1, 6, 12 and 24 months af...
Article
To determine whether staining with iodine solution provides an efficient criterion for determining the area of resection for the lesions surrounding squamous cell carcinoma (SCC) and leukoplakia of the tongue, we determined the optimum density of iodine solution and staining procedure and analyzed the color of lightly stained lesions (LSLs) in rela...
Article
To determine whether the measurement of staining with 3% Lugol's solution provided efficient criteria for determining the area of resection for oral carcinomas and oral potentially malignant disorders, the authors analyzed the color of unstained lesions (USLs) in relation to histopathological findings. After vital iodine staining, USLs were seen in...
Article
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To evaluate the diagnostic accuracy of cone-beam CT in assessing mandibular invasion by lower gingival carcinoma and compare it with that of panoramic radiography. Fifty patients with squamous cell carcinoma of the lower gingiva who were examined by both panoramic radiography and cone-beam CT before surgery were included in this study. Five radiolo...
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Human T-cell leukemia virus type I (HTLV-I) is associated with adult T-cell leukemia, HTLV-I-associated myelopathy/tropical spastic paraparesis and various autoimmune-like disorders. T-cell immune suppression is also associated with HTLV-I infection. Mechanisms of diverse immune dysregulation in HTLV-I infection are obscure. Here, we investigated a...
Article
In the rat tibial bone marrow cavity, following colchicine injection, there is a phase of osteogenesis in which bone trabeculae replace the necrotic bone marrow tissues and fill the marrow cavity. The newly formed bone is subsequently resorbed by osteoclasts and normal bone marrow is restored. In this study, we correlated these morphologic events w...
Article
Human osseous dysplasia (OD) is a benign fibro-osseous neoplasm of periodontal ligament origin in which normal bone is replaced with fibrous connective tissue containing abnormal bone or cementum. However, cellular differentiation and proliferation in OD have not been fully elucidated. In vitro culture systems have distinct advantages for analytica...
Article
Bone regeneration for the defects in revision surgery of joint replacement is an increasingly important issue. To repair bone defects, bone cell activation by growth factors using synthetic resorbable scaffold is a useful and safe option. We examine the efficiency of nanogel-crosslinking hydrogel as a novel synthetic scaffold for BMP to stimulate o...
Article
Amplification of chromosomal DNA is thought to be one of the mechanisms activating cancer-related genes in tumors. To identify the most likely target for amplification in the region 19q13.12-q13.2, detected previously in SKN-3 cells by a genome-wide screening of DNA copy-number aberrations in a panel of oral squamous-cell carcinoma (OSCC) cell line...
Article
TNF-alpha is a major etiologic factor of inflammatory bone diseases such as periodontitis and rheumatoid arthritis. In addition, patients with metabolic diseases such as chronic heart disease and diabetes have significantly increased plasma levels of TNF-alpha. Several lines of evidence show inhibition of osteoblastogenesis by TNF-alpha in vitro. T...
Article
Cyclin D1 gene ( CCND1 ) numerical aberrations are independent prognostic indicators of head and neck squamous cell carcinomas (HNSCCs). High epidermal growth factor receptor gene (EGFR) copy number is associated with poor prognosis in lung cancer, but such findings are controversial in oral SCCs (OSCCs). We analyzed copy number status in CCND1 and...
Article
Cyclin D1 gene (CCND1) numerical aberrations are independent prognostic indicators of head and neck squamous cell carcinomas (HNSCCs). High epidermal growth factor receptor gene (EGFR) copy number is associated with poor prognosis in lung cancer, but such findings are controversial in oral SCCs (OSCCs). We analyzed copy number status in CCND1 and E...
Article
Microvascular free flap transfers have become a preferred reconstructive technique; however, rare complications may still prove devastating. This study reviewed 213 consecutive freetissue transfers in order to assess the incidence and causes of complications in patients undergoing microvascular free flap reconstruction in the oral and maxillofacial...
Article
Synovial chondromatosis is characterized by the formation of osteocartilaginous nodules (free bodies) under the surface of the synovial membrane in joints. Free bodies and synovium isolated from synovial chondromatosis patients expressed high levels of BMP-2 and BMP-4 mRNAs. BMP-2 stimulated the expression of Sox9, Col2a1, and Aggrecan mRNAs in fre...
Article
Cyclin D1 gene (CCND1) numerical aberrations are independent prognostic indicators of head and neck squamous cell carcinomas (HNSCCs). High epidermal growth factor receptor gene (EGFR) copy number is associated with poor prognosis in lung cancer, but such findings are controversial in oral SCCs (OSCCs). We analyzed copy number status in CCND1 and E...
Article
Microvascular free flap transfers have become a preferred reconstructive technique; however, rare complications may still prove devastating. This study reviewed 213 consecutive free-tissue transfers in order to assess the incidence and causes of complications in patients undergoing microvascular free flap reconstruction in the oral and maxillofacia...
Article
The aim of this study was to survey the current state of the temporomandibular joint disorder treatment in our clinic and to confirm the therapeutic outcomes. The subjects in this study were recruited from among the patients with temporomandibular disorders who attended the Temporomandibular Disorder Special Clinic, Department of Oral Surgery, Hita...
Article
Erysipelas is a superficial edematous dermatitis. It is most commonly caused by β-hemolytic streptococci. Recently, it has become a rare disease because of the development of antibacterial agents. A case of facial erysipelas caused by odontogenic infection was presented. The patient visited our hospital with the chief complaint of flare and swellin...
Article
Array-based comparative genomic hybridization (array-CGH) has good potential for the high-throughput identification of genetic aberrations in cell genomes. In the course of a program to screen a panel of 21 oral squamous-cell carcinoma (OSCC) cell lines for genome-wide copy-number aberrations by array-CGH using our in-house bacterial artificial chr...
Article
Recent studies indicate that dental pulp is a new source of adult stem cells. The human tooth with an immature apex is a developing organ, and the apical pulp of this tooth may contain a variety of progenitor/stem cells, which participate in root formation. We investigated the hard tissue regeneration potential of apical pulp derived cells (APDCs)...
Article
Engagement of glucocorticoid-induced TNFR-related protein (GITR) enables the costimulation of both CD25(-)CD4(+) effector (Teff) and CD25(+)CD4(+) regulatory (Treg) cells; however, the effects of GITR-costimulation on Treg function remain controversial. In this study, we examined the effects of GITR ligand (GITRL) binding on the respective function...
Article
To show the characteristic MRI features of synovial chondromatosis (SC) of the temporomandibular joint (TMJ). All patients with histologically proven SC of the TMJ who underwent MRI at our clinic were examined. In 14 patients (male-to-female ratio, 2:12; average age 46+/-14 years), clinical and conventional radiographic findings were reviewed. In a...
Article
CCN3/NOV activates the Notch signal through the carboxyl terminal cysteine-rich (CT) domain. CCN3 transfection to Kusa-A1 inhibited osteogenic differentiation and cell proliferation, which is accompanied by upregulation of Hes/Hey, Notch downstream targets, and p21, a CDK inhibitor. Upregulation of Hes/Hey and p21 was abrogated by the deletion of C...
Article
JunD is an activator protein-1 (AP-1) component though its function in skeletal system is still not fully understood. To elucidate the role of JunD in the regulation of bone metabolism, we analyzed JunD-deficient mice. JunD deficiency significantly increased bone mass and trabecular number. This bone mass enhancement was due to JunD deficiency-indu...
Article
The identification of circulating endothelial progenitor cells (EPCs) has revolutionized approaches to cell-based therapy for injured and ischemic tissues. However, the mechanisms by which EPCs promote the formation of new vessels remain unclear. In this study, we obtained early EPCs from human peripheral blood and late EPCs from umbilical cord blo...
Article
Nerve sheath myxoma is a benign tumor originating from the endoneurium. This tumor rarely occurs in the skin, and nerve sheath myxoma involving the oral cavity is extremely rare. Only 19 cases have been reported to date. This report describes a case of nerve sheath myxoma of the buccal softtissues. A 53-year-old man presented with a painless nodule...
Article
Full-text available
Array-based comparative genomic hybridization (array-CGH) has good potential for the high-throughput identification of genetic aberrations in cell genomes. In the course of a program to screen a panel of oral squamous-cell carcinoma (OSCC), cell lines for genomic copy-number aberrations by array-CGH using our in-house arrays, we identified a 3-Mb h...
Article
In order to define the diagnostic value of cyclin D1 gene (CCND1) numerical aberration as a clonal marker in oral squamous cell carcinomas (OSCCs), we investigated copy number changes of the CCND1 in 32 OSCC primary tumors(PTs) and matched lymph node metastases(LNMs) taken by fine-needle aspiration(FNA) biopsies using fluorescence in situ hybridiza...
Article
Cronkhite-Canada syndrome (CCS) is a rare, sporadically occurring and non-familial syndrome. We report a case of CCS with hypogeusia. A 68-year-old male was suffering from diarrhea and anorexia. Endoscopic examination revealed gastrointestinal polyposis. He visited our clinic complaining of taste disturbance. Together with hyperpigmentation of skin...
Article
Cyclin D1 (CCND1) and p16 alterations have been detected in oral squamous cell carcinomas (SCCs), suggesting that abnormalities of these genes may play an important role in the genesis or progression of oral SCCs and serve as independent prognostic indicators. The detection of CCND1 and p16 aberrations using a simple and sensitive method would be v...
Article
Oral leukoplakia and its malignant transformation are reviewed in this article. Oral leukoplakia is defined as a predominantly white lesion of the oral mucosa that can not be characterized as any other definable lesion; however, the lesion must be confirmed histopathologically by biopsy in order to discuss malignant transformation of oral leukoplak...
Article
Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Since tumor metastasis shortens patients' lifetime, establishment of therapy for anti-metastasis is very important. Osteopontin (OPN), which abundantly expressed in bone matrix, is involved in cell adhesion, migration, extracellular matri...
Article
The human tooth with immature apex is a developing organ available for investigation. In this tooth, especially in the apical pulp, the proliferation and differentiation of various cells are activated to make a complete tooth. We investigated the notion that unique cells are included in the apical pulp of human tooth with immature apex. Human impac...
Article
Background: To assess tissue characterization of oral tongue cancer and prediction of subclinical cervical lymph node metastasis, we investigated whether intraoral ultrasonography could be used in conjunction with a computer-aided diagnosis (CAD) system. Methods: The study population comprised 109 patients with presurgical, clinical T1N0 or T2N0...
Article
The cyclic peptide WP9QY (YCWSQYLCY) was designed to mimic the most critical tumor necrosis factor alpha (TNFalpha) recognition loop on TNF receptor I, and it prevents interactions of TNFalpha with its receptor. We undertook this study to compare the effects of the WP9QY peptide on collagen-induced arthritis (CIA) in mice with those of anti-TNFalph...
Article
We previously reported that GITR acts as a costimulatory molecule in both CD25− CD4+ conventional and CD25+ CD4+ Treg cells using agonistic anti-GITR mAb (DTA-1) (J. Immunol. 2004, 172:7306). However, CD4 T cell responses by the binding of natural ligand, GITRL and the physiological importance of GITR-GITRL pathway have not been well understood. In...
Article
Full-text available
Facial nerve neuropathy is a rare postoperative complication in orthognathic surgery. Once it has occurred, however, it is not only physically but also mentally a serious problem. We describe here two cases of unilateral peripheral facial nerve palsy following orthognathic surgery. Case 1: A 19-year-old male having mandibular prognathism with facia...
Article
Oral leukoplakia and its malignant transformation are reviewed in this article. Oral leukoplakia is defined as a predominantly white lesion of the oral mucosa that can not be characterized as any other definable lesion; however, the lesion must be confirmed histopathologically by biopsy in order to discuss malignant transformation of oral leukoplak...
Article
生体内吸収性のポリ-L-乳酸(PLLA)メッシュと骨髄海綿骨細片(PCBM)用いた下顎骨再生法を中心にして,下顎骨の再構築法について述べた。腫瘍57例(悪性腫瘍23例,良性腫瘍34例)の6か月後の臨床評価では,著効が30例(52.6%),有効が17例(29.8%),無効が10例(17.5%)であった。1-11(平均5.3年)年の長期観察では,39例中,31例(79.5%)が10%未満の吸収に留まった。メッシュに起因する有害事象はみられなかった。再生骨への義歯装用は21例,歯科インプラント施行例は4例であった。本法は従来の骨移植法に比べて,手術侵襲が少なく,形態と機能回復に優れている。今後,局所の血行不良例,高齢者や8cmを越えるような広範囲の区域切除例に対しては,血行の確保とともに,骨形成を...
Article
Historically, arsenic trioxide (AT) was commonly used in endodontic treatment because it acts quickly and devitalizes the pulp within two days. However, it is cytotoxic to gingiva and bone. If it diffuses out of the cavity it can readily cause widespread necrosis of gingiva and bone, which can lead to osteomyelitis of the jaws. This article present...
Article
Full-text available
Many different factors are known to cause and perpetuate the symptoms of temporomandibular disorders (TMD). However, the roles of parafunctional factors have not been clearly elucidated. We found one of these habits in the clinical setting. This parafunctional habit involves daily light touching of the upper and lower teeth, when the mouth is close...
Article
This study investigated neurosensory disturbances in patients after orthognathic surgery in relation to differences in mandibular splitting methods and degree of surgical skill. Forty-five patients who had undergone bilateral sagittal split ramus osteotomies (SSRO), and 21 (group L) who had undergone intraoral inverted L ramus osteotomies (ILRO), w...
Article
The effect of acupuncture in sensory paralysis was evaluated in 43 patients. Thiry-two cases in the study group were after mandibular third molar extraction and 11 cases by postoperative injury of orthognathic surgery. Treatment was performed in four forms: needles only (A), A with moxibustion (AK), electrical needle stimulation (ESA) using LEP 400...
Article
Full-text available
Whether MR imaging is superior to CT in evaluating the presence and extent of mandibular invasion by squamous cell carcinoma remains controversial. The purpose of this study was to directly compare the diagnostic accuracy of MR imaging and that of CT. MR and CT images in 51 patients with squamous cell carcinoma of the oral cavity were evaluated for...
Article
Full-text available
Retroviral integrase (IN) catalyzes the integration of viral cDNA into a host chromosome. Additional roles have been suggested for IN, including uncoating, reverse transcription, and nuclear import of the human immunodeficiency virus type 1 (HIV-1) genome. However, the underlying mechanism is largely unknown. Here, using a yeast two-hybrid system,...
Article
One hundred and four patients with pleomorphic adenoma diagnosed at the Maxillofacial Surgery Department, Tokyo Medical and Dental University Hospital during 15 years from January 1988 to December 2002, were reviewed. The results were as follows: 1. Of the 104 patients with pleomorphic adenoma, 34 were males and 70 were females, and the male to fem...
Article
This study assessed the clinicopathological and immunohistochemical characteristics of benign and malignant vascular lesions using Factor VIII Related-Antigen (FVIIIRAg), CD31, CD34, VEGF, Ki-67, SMA (smooth-muscle actin), and D2-40. Eighty-one cases were collected: 15 VN (vascular neoplasms) (mean age of 43.34 ± 19.45 years old, 1.2:1 male:female...
Article
Obstructive sleep apnea syndrome (OSAS) is a life-threatening breathing disorder. We describe a patient with micrognathia and OSAS who underwent mandibular advancement by bilateral mandibular distraction osteogenesis. A 36-year-old man had micrognathia due to neonatal bilateral temporomandibular joint ankylosis. He also had severe OSAS. Conservativ...
Article
The EGFR/Ras/Raf/MEK/ERK pathway is a major pathway involved in the control of growth signals, cell survival and differentiation. Mutations of signaling components, such as EGFR (c-erbB1), Ras, and B-Raf, have been shown to play roles in the genesis of human cancer, while point mutation of ERK has not been reported. In this study, we present eviden...

Citations

... 2 In the present patients, perception on the resected side was improved at all measurement points in terms of tactile and cold sensation, although sensitivity on the resected side remained below the normal range. Results for the lower lip, tongue, and chin were broadly similar to those described by Mochizuki et al. 12 Bare bone graft avoids the need for secondary revision and involves epithelialization of the exposed iliac bone surface in the oral cavity. This method carries an expectation of improved gingival perception on 12 reported that recovery of warmth perception in the lower lip, tongue, and chin on the resected side was slower than that of cold or tactile perception. ...
... These observations suggest that CCND1 is a pivotal downstream target gene in EGFR-driven tumorigenesis. Therefore, the genetic statuses of not only EGFR but also CCND1 are needed to predict the therapeutic effects of EGFR inhibitors [19,41]. In our observations, OSCC patients with two concomitant events have the worst prognosis ( Figure 2B, Table 4). ...
... Apart from this, venous congestion, bleeding, partial flap necrosis, and orocutaneous fistula formation were more common in free fibula cases. Other authors reported a similar trend of higher complication rates between bone-containing free flaps compared with pure soft-tissue ones [29][30][31]. We used the fibula as a double paddle for lining and covering both based on different skin perforators. ...
... We summarized our case and 58 previously reported cases of facial palsy after orthognathic surgery [1][2][3][4][5]. The data consisted of 26 males and 33 females (average age was 23.4 years old). ...
... Despite the high incidence, studies indicate that dentists still have difficulties in diagnosing oral The diagnosis must be made based on a thorough anamnesis, identifying risk factors such as the presence or absence of symptoms, delayed healing of mucosal lesions, smoking, drinking, oral HPV infection, long-term exposure to sunlight, old age, genetic diseases and lack of oral hygiene. All of these aspects must be considered together with early diagnosis [24][25][26][27][28][29][30][31][32][33][34][35][36] . ...
... They are most often localized at the lower extremities, however the facial localization prevailed during the first part of the 20 th century [3,4]. Actually, erysipelas is among the rare infections causing acute inflammatory redness of the face [5,6]. Cellulitis and erysipelas are usually thought to be caused by group A streptococci, and other microorganisms such as Staphylococcus aureus may be less frequent causes [2]. ...
... Sleep apnea is a common disorder with significant adverse health consequences. 1 The narrowing of airway causes increase in negative intrathoracic pressure during sleep, which results in sleep fragmentation and excessive daytime somnolence. The prolonged consequences are obesity, glucose intolerance, hypertriglyceridemia, and hypertension, described as a deadly quartet. ...
... Most oral cancers are preceded by precursor conditions collectively identified as "oral potentially malignant disorders" (OPMD). This risk of malignancy in an OPMD can be present in a lesion during the initial diagnosis or can develop later [9]. Therefore, it is of paramount importance that patients diagnosed with OPMD are investigated with biopsy and followed up with adequate time intervals to prevent and or early detect malignant transformation. ...
Citing chapter
... The participants comprised 296 men and 712 women, with a mean age of 28 years (13)(14)(15)(16)(17)(18)(19) years, n=144; 20-29 years, n=483; 30-39 years, n=236; 40-49 years, n=102; 50-59 years, n=39; ≥60 years, n=4). ...
... By contrast, for advanced (late stage T2 to T4) and posterior region cancers, multidisciplinary combination therapy with preoperative 5FU intra-arterial chemoradiotherapy (5FU 100 ~ 300 mg for 21 days) with cannulation from the super cial temporal artery followed by surgical treatment in the form of maxillary resection and neck dissection is preferred. [9] The radiation dose is 40 to 50 Gy for primary lesions and 30 to 40 Gy for cervical lymph node metastasis. The maxillary resection line is determined preoperatively according to the tumour extension. ...