Tatsuo Kuroda's research while affiliated with Keio University and other places
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Publications (163)
Purpose
Survival rates of patients with high‐risk neuroblastoma are unacceptable. A time‐intensified treatment strategy with delayed local treatment to control systemic diseases has been developed in Japan. We conducted a nationwide, prospective, single‐arm clinical trial with delayed local treatment. This study evaluated the safety and efficacy of...
Introduction
Intractable lymphatic anomalies (LAs) include cystic lymphatic malformation (LM; macrocystic, microcystic, or mixed), generalized lymphatic anomaly, and Gorham–Stout disease. LAs can present with severe symptoms and poor prognosis. Thus, prospective studies for treatments are warranted. We conducted a prospective clinical trial of siro...
No standard diagnostic method or surgical treatment for congenital isolated hypoganglionosis (CIHG) has been established. This study aimed to analyze the clinical outcomes of patients with CIHG and identify the best surgical interventions provided thus far. Data on surgical interventions in 19 patients were collected between 1992 and 2020, includin...
Aim
To evaluate the use of donor‐derived cell‐free DNA (dd‐cfDNA) in diagnosing graft injuries in Japanese liver transplantation (LTx), including family‐related living donors.
Methods
A total of 321 samples from ten newly operated LTx recipients were collected to monitor the early dynamics of dd‐cfDNA levels after LTx. Fifty‐five samples from 55 r...
Objective:
To identify patients with biliary atresia (BA) with extremely poor outcomes of bile drainage surgery using the infant BA liver fibrosis (iBALF) score, a liver fibrosis marker based on standard blood analysis.
Summary background data:
Although primary liver transplantation (LTx) is beginning to be considered as an alternative to bile d...
Background:
Patients with intestinal failure (IF) often present with abnormal body composition characterized by high fat mass. However, the distribution of fat and its association with the development of intestinal failure-associated liver disease (IFALD) remain unclear. This study aims to investigate the body composition and its relationship with...
Introduction:
Reports of liver transplantation (LT) after Kasai portoenterostomy (KPE) in adult patients with biliary atresia are scarce. The aim of this study was to evaluate the outcomes and investigate the risk factors of LT after KPE in both pediatric and adult patients.
Methods:
We retrospectively reviewed a prospective database of patients...
Pallister–Hall syndrome (PHS) is defined as a group of characteristic manifestations caused by a monoallelic GLI3 pathogenic variant. A two-month-old infant was referred to our institution because of undetermined sex. The infant had atypical genitalia with postaxial polysyndactyly, a hypothalamic mass, and an imperforate anus. We identified a known...
Biliary complications after hepatectomy in living donors have yet to be eradicated. We hypothesized that a standardized upfront Glissonean approach and liver hanging maneuver (GH) would prevent mechanical and thermal injuries to the hilar plate of the remnant liver by determining the point of bile duct division and the final destination of hepatect...
Background
Some neuroblastoma (NB) cases are suitable for minimally invasive surgery (MIS), but indication and technical issue are unclear. We assessed the current status of MIS for abdominal NB after mass screening period in Japan.Methods
Preliminary questionnaires requesting the numbers of NB cases that underwent MIS from 2004 to 2016 were sent t...
Purpose
: The application of slide tracheoplasty (STP) in the treatment of congenital tracheal stenosis (CTS) has improved patient outcomes over the past few decades. We reviewed our experiences with the procedure, elucidated risk factors, and discussed important aspects of perioperative management to improve outcomes.
Method
: Patients with CTS u...
Background
5-Aminolevulinic acid (ALA)-based photodynamic therapy (PDT) is widely used in cancer therapy because of the tumor-specific accumulation of photosensitizing protoporphyrin IX (PpIX). We aimed to assess the susceptibility of human neuroblastoma cell lines to ALA-PDT and determine the mechanism of PDT.
Methods
We used four human neuroblas...
Background
In Japan, allogeneic hematopoietic stem cell transplantation is widely performed for recurrent neuroblastomas. This retrospective study aimed to investigate the prognosis of recurrent neuroblastoma in Japan and explore the effectiveness of allogeneic hematopoietic stem cell transplantation.
Methods
Clinical characteristics and data on t...
Background:
Erythropoietic protoporphyria (EPP) is a rare inherited disorder that causes the accumulation of protoporphyrin in the erythrocytes, skin, and liver. Severe protoporphyric hepatopathy results in liver failure, requiring both liver and bone marrow transplantation as a life-saving procedure and to correct the underlying enzymatic defect,...
Background
Minimally invasive surgery (MIS) is appropriate for the treatment of some neuroblastomas (NBs); however, the indications and technical issues are unclear. This study aimed to clarify the current status of MIS for mediastinal NB in Japan.
Methods
Preliminary questionnaires requesting the numbers of neuroblastoma cases in which MIS was pe...
Background
Infectious complications after solid organ transplantation can be fatal, and early diagnosis and intervention are important. To the best of our knowledge, no study has examined the diagnostic utility of presepsin, a known accurate biomarker, for infectious complications after liver transplantation. This study aimed to evaluate the utilit...
Considering that some biliary atresia (BA) survivors with native liver have reached reproductive age and face long-lasting complications, specific attention needs to be paid to pregnant cases. This study aimed to investigate the relationship between liver function, perinatal outcomes, and prognosis. A database review was conducted to identify pregn...
Background:
Evidence has been published on the successful applications of the anti-tumor necrosis factor alpha antibody infliximab, such as induction therapy, salvage treatment for acute cellular rejection, and treatment for chronic ulcerative inflammation, in intestinal transplant recipients. However, the optimal protocol for the effective use of...
Biliary stricture is a serious postoperative complication of liver transplantation. We report the case of a 2-year-old boy with severe biliary anastomotic stricture after left lobe living donor liver transplantation. As cannulation from the occluded B3 into the jejunum was impossible using the conventional technique, a gunsight approach was utilize...
The Japanese Biliary Atresia Society (JBAS) prepared for clinical practice guidelines for biliary atresia (BA) according to the Medical Information Network Distribution Service (MINDS) Handbook 2014. Twenty-five clinical questions (CQs) essential for daily clinical practice for BA were grouped into diagnosis, treatment, complications, and prognosis...
The occurrence of fetuses suspected of having ambiguous genitalia will likely increase in the future. Currently, the impact of prenatal genetic counseling on parents' understanding and psychological preparedness has not been addressed. We provided prenatal genetic counseling to parents of two fetuses suspected of ambiguous genitalia. Case 1: At 22...
Objectives
The efficacy of sodium phenylbutyrate (SPB) for hyperammonemia associated with congenital portosystemic shunt (CPSS) remains unknown. We show the effectiveness of oral SPB.
Case presentation
Our patient had CPSS with severe hypoplasia of extrahepatic portal veins. At 9 months of age, to assess the efficacy of oral SPB, we evaluated the...
Introduction
Decellularized tissue exhibits cell matrix-like properties, along with reduced antigenicity. We explored the potential of decellularized allogeneic trachea to restore the upper respiratory tract, focusing on pediatric application. This study specifically aimed at long-term observation of tissue regeneration using a micro-miniature pig...
Background:
Postoperative recurrence of tracheoesophageal fistula (TEF) is a frequent complication in the repair of esophageal atresia (EA). Based on the recent etiologic classification, a TEF that develops in a different new pathway from the original one is categorized as an acquired TEF. The TEFs that fall into this category have been reported t...
Purpose
The purpose of this study was to prepare clinical practice guidelines for biliary atresia according to the Medical Information Network Distribution Service (MINDS) Handbook for Clinical Practice Guideline Development 2014.
Methods
The guideline drafting group determined 25 clinical questions (CQs) essential for daily clinical practice. The...
In the October 2018 issue of International Journal of Clinical Oncology.
In this unprecedented COVID-19 pandemic, several key issues must be addressed to ensure safe treatment and prevent rapid spread of the virus and a consequential medical crisis. Careful evaluation of a patient’s condition is crucial for deciding the triage plan, based on the status of the disease and comorbidities. As functionality of the medical ca...
The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence-based medicine (EBM) techniques and aimed at improvement of the outcomes. Clinical questions (CQs) were de...
The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety and systematizing treatment, employing evidence‐based medicine techniques and aimed at improvement of the outcomes. Clinical questions (CQ) were decided ba...
The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence‐based medicine (EBM) techniques and aimed at improvement of the outcomes. Clinical questions (CQs) were de...
Background
Hirschsprung's disease is a congenital abnormality of the enteric nervous system (ENS) presenting severe constipation soon after birth due to the lack of ganglion cells in the distal gut. Surgery for Hirschsprung's disease requires an intraoperative histopathological diagnosis to assess the extent of aganglionosis. Confocal laser endomic...
Background:
Blood stream infection (BSI) is a life-threatening complication after living donor liver transplantation (LDLT). We aimed to explore the incidence and predisposing factors of BSI at our institution.
Methods:
We conducted a retrospective cohort analysis on all consecutive adults with BSI within six months after LDLT performed between...
Fluorescence-guided surgery with indocyanine green (ICG) for malignant hepatic tumors has been gaining more attention with technical advancements. Since hepatoblastomas (HBs) possess similar features to hepatocellular carcinoma, fluorescence-guided surgery can be used for HBs, as aggressive surgical resection, even for distant metastases of HBs, of...
The curability of chemotherapy-resistant hepatoblastoma (HB) largely depends on the achievement of radical surgical resection. Navigation techniques utilizing indocyanine green (ICG) are a powerful tool for detecting small metastatic lesions. We herein report a patient who underwent a second living donor liver transplantation (LDLTx) for multiple r...
Tumors comprise heterogeneous cell types including cancer stem cells (CSC), progenitor cells, and differentiated cells. Chemoresistance is a potential cause of relapse and a key characteristic of CSC, but the development of novel therapeutic approaches for targeting these cells has been limited. We previously established osteosarcoma-initiating (OS...
We report the case of a 53-year-old-man who developed human T-cell leukemia virus type-1-associated myelopathy (HAM) after ABO-incompatible liver transplantation for alcoholic liver cirrhosis. The living donor was seropositive for human T-cell leukemia virus type-1 (HTLV-1) and the recipient was seronegative for HTLV-1 before transplantation. After...
Introduction:
Lymphatic anomalies (LAs) refer to a group of diseases involving systemic dysplasia of lymphatic vessels. These lesions are classified as cystic lymphatic malformation (macrocystic, microcystic or mixed), generalized lymphatic anomaly, and Gorham-Stout disease. LAs occur mainly in childhood, and present with various symptoms includin...
Extrahepatic congenital portosystemic shunts (CPSSs) can be occluded by surgical or endovascular approaches. However, when the estimated portal vein (PV) pressure after the closure is high enough to induce symptoms associated with portal hypertension, partial closure is recommended to avoid life-threatening events. In this study, we attempted lapar...
Background/purpose:
This study aimed to assess the significance of tumor debulking surgery by using immune checkpoint inhibitors for advanced pediatric solid tumors in a murine model of advanced osteosarcoma.
Methods:
In C3H mice, 5 × 106 LM8 (osteosarcoma cell line with a high metastatic potential in the lungs originating from the C3H mouse) ce...
Background:
The risk factors for rapid growth and early metastasis of papillary thyroid carcinoma (PTC) and the role of coexisting Graves' disease in the clinical course of PTC remain uncertain in children.
Case description:
We report on a Japanese girl, whose PTC rapidly grew and metastasized within 4 years. Graves' disease was diagnosed by the...
We report the case of a 53-year-old-man who developed human T-cell leukemia virus type-1-associated myelopathy (HAM) after ABO-incompatible liver transplantation for alcoholic liver cirrhosis. The living donor was seropositive for human T-cell leukemia virus type-1 (HTLV-1) and the recipient was seronegative for HTLV-1 before transplantation. After...
Background:
Secondary cancer is the most life-threatening late effect of childhood cancer. We investigated the clinical features of secondary bone/soft tissue sarcoma among childhood cancer survivors (CCSs).
Methods:
We conducted a retrospective case-series study of 10 069 CCSs newly diagnosed with cancer between 1980 and 2009 across 15 Japanese...
Background:
The curability of hepatoblastoma (HB) largely depends on the achievement of radical surgical resection, even for metastatic tumors. However, the extension of the metastatic tumor when viewed through an endoscope with the conventional white-light mode is often unclear. Advancements in imaging technology utilizing indocyanine green (ICG)...
Backgrounds:
Multidisciplinary therapy has increased the risk of subsequent late effects, but detailed analyses on secondary cancers in childhood cancer survivors (CCSs) are limited in Asian countries.
Methods:
This was a retrospective cohort study comprising 10,069 CCSs who were diagnosed between 1980 and 2009 across 15 Japanese hospitals. We c...
Background
Despite the presence of ganglion cells in the rectum, some patients have symptoms similar to those of Hirschsprung's disease. A consensus has yet to be established regarding the terminology for these diseases. We defined this group of diseases as “allied disorders of Hirschsprung's disease” and compiled these guidelines to facilitate acc...
Background:
The Japanese Children's Cancer Group (JCCG) Neuroblastoma Committee (JNBSG) conducted a phase II clinical trial for high-risk neuroblastoma treatment. We report the result of the protocol treatment and associated genomic aberration studies.
Methods:
JN-H-07 was a single-arm, late phase II trial for high-risk neuroblastoma treatment w...
Children with single ventricle physiology have complete mixing of the pulmonary and systemic circulations, requiring staged procedures to achieve a separation of these circulations, or Fontan circulation. The single ventricle physiology significantly increases the risk of mortality in children undergoing non-cardiac surgery. As liver transplantatio...
Background. Multiple studies have failed to reveal an effective method for preventing the recurrence of primary sclerosing cholangitis (PSC) after liver transplantation (LTx). A national study conducted in Japan revealed several risk factors for the recurrence after living donor LTx (LDLTx); however, recipients of ABO-blood type incompatible (ABO-I...
PurposeTracheal cartilage reconstruction is an essential approach for the treatment of tracheal congenital abnormalities or injury. Here, we evaluated the use of allogeneic decellularized tracheas as novel support scaffolds. Methods
Six weaned pigs (4-week-old domestic males) were transplanted with allogeneic tracheal graft patches (three decellula...
Background/purpose:
The prognosis of patients with metastases remains unsatisfactory in certain pediatric solid tumors. In this study, we evaluated the efficacy of immune checkpoint inhibitors against such metastases using a murine model of osteosarcoma.
Methods:
Murine osteosarcoma LM8 cells were transplanted subcutaneously into C3H mice. The p...
Growing evidence suggests a relationship between antibody-mediated rejection (AMR) and early graft failure due to a previously unknown etiology in liver transplantation (LTx). We herein report a three-year-old boy who developed rapid graft failure due to de novo donor-specific antibody (DSA)-driven AMR a week after living donor LTx, requiring a sec...
Objectives:
More than two decades have passed since the first living donor liver transplantation was performed in Japan in 1989. There are many reports about problems in adherence to taking medication and medical follow-ups in children who received liver transplants, because there is no transition strategy for those children and parents or guardia...
Background and aim:
In preceding studies, we identified that some fluorescent agents cloud visualization of the myenteric plexus (MP) with confocal laser endomicroscopy (CLE). In this study, we evaluated the technical feasibility of MP visualization using probe-based CLE (pCLE) with cresyl violet (CV), which has been used clinically for chromoendo...
Many papers have reported on pregnancy and delivery after liver transplantation, but there have been no reports on pregnancy after ABO-incompatible liver transplantation. This paper reports the first successful pregnancy and delivery of a newborn after ABO-incompatible liver transplantation for fulminant hepatic failure. The patient was a 39-year-o...
Background
Biliary atresia commonly leads to liver fibrosis and cirrhotic complications, including esophageal varices.
Objective
To evaluate liver and spleen stiffness measurements using acoustic radiation force impulse (ARFI) imaging for diagnosing grade of liver fibrosis and predicting the presence of esophageal varices in patients treated for bi...
Purpose:
The current study aimed to assess the perinatal risk and clinical features of congenital cystic lung diseases (CCLD).
Materials and methods:
Of the 874 CCLD patients identified in a nationwide survey, 428 patients born between 1992 and 2012 and treated at 10 high-volume centers, were retrospectively reviewed.
Results:
Fetal hydrops wa...
Surgical procedures for representative pediatric diaphragmatic diseases, congenital diaphragmatic hernia and diaphragmatic eventration, are described in this chapter. In congenital diaphragmatic hernia, a repair through laparotomy under direct vision is the most common procedure. Patch repair is sometimes required for huge diaphragmatic defect. Rec...
Mesenchymal stem cells (MSCs) are defined as non-hematopoietic, plastic-adherent, self-renewing cells that are capable of tri-lineage differentiation into bone, cartilage or fat in vitro. Thus, MSCs are promising candidates for cell-based medicine. However, classifications of MSCs have been defined retrospectively; moreover, this conventional crite...
The outcome of LTx in pediatric patients with FHF of unknown etiology remains inferior to that of LTx in pediatric patients with cholestatic diseases. A higher incidence of steroid-resistant severe rejection has been increasingly recognized among the responsible factors. We assessed the efficacy of the administration of steroids and PGE1 via PVI in...
The ablated ganglion cells in myenteric and submucosal plexus.
(A) In the intact colon, PGP9.5 positive ganglion cells and GFAP positive glial cells were localized both in the myenteric plexus and in the submucosal plexus. (B) After the chemical treatment, ganglion cells and glial cells are disappeared from the all layer at the center region of the...
Gastrointestinal motility disorders, severe variants in particular, remain a therapeutic challenge in pediatric surgery. Absence of enteric ganglion cells that originate from neural crest cells is a major cause of dysmotility. However, the limitations of currently available animal models of dysmotility continue to impede the development of new ther...
The GFP expression in the autonomic nerve in P0-Cre/GFP mouse gut.
The subtype of the GFP+ cells in P0-Cre/GFP mouse gut evaluated by immunohistochemistry with the specific markers for parasympathetic and sympathetic nerve fibers. (A-C) CGRP, SubP and VAChT, parasympathetic nerve markers, did not colocalize with GFP in P0-Cre/GFP gut. (D) The limit...
Cell type specificity of the apoptotic cells.
ENS in the gut at 12 hours after chemical treatment was immunostained with the markers for ganglion cells, smooth muscle and apoptosis. The ganglion cell aggregation was highly positive for apoptosis marker, but negative for neuronal marker located between the smooth muscle layers. A limited number of s...
Direct effect on GFP by the BAC application.
The direct BAC effect for the fluorescence protein itself was evaluated with the fixed GFP+ cells with or without BAC application. The GFP intensity was slightly decreased after the BAC treatment observed with the fluorescence microscope. Scale bar, 20 μm
(TIF)
Background:
Complex lymphatic anomalies are intractable lymphatic disorders, including generalized lymphatic anomaly (GLA), Gorham-Stout disease (GSD), and kaposiform lymphangiomatosis (KLA). The etiology of these diseases remains unknown and diagnosis is confused by their similar clinical findings. This study aimed to clarify the differences in c...
Immunoassays (IAs) are widely used to measure concentration of serum estradiol (E2) despite some limitations including cross-reactivity. Liquid chromatography-tandem mass spectrometory (LC-MS/MS) for E2 measurement has a theoretically greater specificity and sensitivity than IAs. We report a case with unexpected discrepancy in E2 values measured by...
Background:
The epidemiology of secondary cancers in childhood cancer survivors has been unknown in Asian countries. Our aim is to assess the incidence and risk factors for secondary cancers through a nationwide survey in Japan.
Methods:
A retrospective cohort study comprising 10,069 children who were diagnosed with cancer between 1980 and 2009...
Overall survival proportions of 2-month survivors
Comparison of secondary cancer distribution among previous reports (all/2-month survivors and 5-year survivors)
Objectives:
Most biliary atresia (BA) patients suffer from liver fibrosis and often require liver transplantation. The aim of this study was to develop and validate a novel fibrosis marker for BA patients aged <1 year-the infant BA liver fibrosis (iBALF) score-subsequent to the previously reported fibrosis marker for BA patients aged ≥1 year.
Met...
Aim The current study aimed to assess the perinatal risk of congenital cystic lung diseases (CCLD) and to establish a suitable surgical strategy in consideration of postoperative lung growth and problems during adulthood.
Methods Among 874 CCLD patients identified in a nationwide survey, 428 patients were born between 1992 and 2012 and treated at 1...
Intestinal volvulus without malrotation is a rare disease that causes volvulus of the small intestine despite normal intestinal rotation and fixation. We encountered a neonate with this disease who developed early jaundice and was suspected to have a fetal onset. This patient was characterized by early jaundice complicating intestinal volvulus with...
Background:
Early initiation of enteral nutrition is recommended after some surgical procedures. This study retrospectively analyzed the effects of addition of early enteral nutrition (EEN) support during the postoperative phase in patients after living-donor liver transplantation (LDLT).
Material and methods:
The subjects were adult patients wh...
A 7-year-old boy undergoing home parenteral nutrition with totally implantable central venous access device for chronic intestinal pseudo-obstruction experienced repeated episodes of fever with a temperature above 39.0 °C despite the antibiotic treatment. The fever was considered to be catheter-related blood stream infections, as no other etiology...
Aim:
Recent randomized trials have failed to prove the benefit of steroid-free immunosuppression in liver transplantation for hepatitis C virus (HCV)-related cirrhosis. Furthermore, there is a lack of data on the use of basiliximab in living donor liver transplantation (LDLT). This pilot study evaluated the safety and efficacy of a steroid minimiz...
Background
Living donor liver transplantation in children often results in venous complications, leading to portal hypertension. Spleen stiffness measurements have been recently proposed as a new, noninvasive parameter for portal hypertension in cirrhotic patients.
Objective
To evaluate the diagnostic value of spleen stiffness measurements by acous...
Stem cell therapy offers the potential of rebuilding the enteric nervous system (ENS) in the aganglionic bowel of patients with Hirschsprung's disease. P0-Cre/Floxed-EGFP mice in which neural crest-derived cells express EGFP were used to obtain ENS stem/progenitor cells. ENS stem/progenitor cells were transplanted into the bowel of Ret(-/-) mouse,...
Purpose:
Intestinal neuronal dysplasia Type B (IND-B) has been proposed to be an allied disorder of Hirschsprung's disease (ADHD). The original histological criteria included hyperganglionosis, giant ganglia, ectopic ganglion cells and an increased AChE activity in the lamina propria. The criteria for IND-B have been gradually revised. The present...
Fetuses with concomitant duodenal atresia (DA) and esophageal atresia (EA) might develop in utero gastric rupture as well as neonatal respiratory complication due to dilated stomach and duodenum. Our patient with the typical “double bubble” appearance was highly suspected to have DA in the second trimester. Follow-up examinations revealed a massive...
Background:
We present our attempts at reducing the length of incision in living donor left-side hepatectomy without laparoscopic approach.
Methods:
The chief surgeon initially made a 10-cm upper midline incision and performed all procedures through a minilaparotomy without abdominal wall lifting or pneumoperitoneum. For the procedures in the la...
Background & Aims
Although liver fibrosis is an important predictor of outcomes for biliary atresia (BA), postsurgical native liver histology has not been well reported. Here, we retrospectively evaluated postsurgical native liver histology, and developed and assessed a novel scoring system—the BA liver fibrosis (BALF) score for noninvasively predi...
Mowat-Wilson syndrome (MWS) is a multiple congenital anomaly syndrome characterized by moderate or severe intellectual disability, a characteristic facial appearance, microcephaly, epilepsy, agenesis or hypoplasia of the corpus callosum, congenital heart defects, Hirschsprung disease, and urogenital/renal anomalies. It is caused by de novo heterozy...
The International Society for the study of Vascular Anomalies (ISSVA) classification divides vascular lesions into two major entities: neoplasms originating from the vascular endothelium and vascular malformations. Although this concept has been widely accepted, little has been established regarding vascular lesions in deep organs, such as infantil...
Background
The use of nuclear medicine for the management of malignant tumor, such as radioguided surgery and sentinel lymph node biopsy (SLNB), has been widely accepted in the adult practice. However, there are very few studies to apply those techniques for pediatric diseases. The aim of this is to investigate the feasibility of application of nuc...
Recently, liver transplantation (LT) has been increasingly performed for unresectable hepatoblastoma (HB) with acceptable results. We conducted a national survey of cases undergoing living donor liver transplantation (LDLT) for HB to evaluate their outcomes. Thirty-nine patients (28 males and 11 females with a median age at LDLT of 3.6 years) who h...
Citations
... In cases of rejection, and particularly acute rejection, the use of dd-cfDNA proved to be more sensitive and diagnostically valuable than liver function tests (LFTs), enabling an earlier and more accurate detection. Many studies have indicated that LT recipients experiencing acute rejection exhibit higher serum levels of dd-cfDNA compared to those without rejection, with the median dd-cfDNA percentage being three-fold higher comparing to before rejection diagnosis levels [50,[56][57][58][59]. The sensitivity and specificity of dd-cfDNA-based acute rejection diagnosis differentiated, ranging between 72 and 100% and 53-91% based on different cutoff levels. ...
... BDP was known to have a prognostic value in BA, and an increase in BDP was associated with fibrosis progression in BA [21]. The preoperative iBALF score predicted the poor outcome of bile drainage surgery in BA patients and may be considered as a candidate for primary liver transplantation [30]. The AUC of prognosis for BA-specific staging combined with iBALF and severe BDP was higher than BA-specific staging alone, suggesting that combining these features would make it more appropriate for assessing BA prognosis. ...
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... Briefly, by maintaining ventral retraction of the tape around the hepatoduodenal ligament, the right Glissonean pedicle is gently and bluntly dissected off the liver surface preserving the Laennec's capsule from the dorsal side of the hepatic hilum toward the cranial edge of the hilar plate. Next, the tape around the hepatoduodenal ligament is pulled caudally and the right Glissonean pedicle is fully dissected off the liver surface from the ventral side of the hepatic hilum and the Glissonean pedicle is encircled by a tape [20]. Intraoperative central venous pressure was maintained at 5-8 mmHg, and circulatory dynamics remained stable during hepatectomy. ...
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... CTR adversely affects perioperative respiratory management following TEF/EA repair. Granulation formation of the CTR by tracheal tube contact easily causes respiratory insufficiency [20]. Furthermore, patients with this condition often have other respiratory anomalies such as CBPFM [10,11] or unilateral pulmonary agenesis [14], similar to those in this study. ...
... Early cancer detection improves treatment outcomes, and a technique that combines both detection and treatment is very advantageous because it can cut treatment costs tremendously. Photodynamic diagnosis, which has many advantages over the standard white light cystoscopy, is recommended by the European Association of Urology (EAU) as a diagnostic procedure in cases of suspected carcinoma in situ [55]. Most cancer symptoms tend to be unspecific, and most small flat lesions can easily be missed by standard white light cystoscopy. ...
... Sixty-six cases of liver transplantation for EPP have been reported (Endo et al. 2022, A c c e p t e d M a n u s c r i p t 13 donor liver transplantation. Only four cases of living-donor liver transplantation have been reported (Tanaka et al. 1994, Wahlin et al. 2011, Yamashita et al. 2020, and our report is the only one that describes the detailed perioperative management and prognosis. ...
... The CIBMTR conducted a retrospective review showing some benefit for allo-HCT in patients without prior auto HCT (Hale et al. 2013). The Japan Children's Cancer Group (JCCG) (Hara et al. 2022) reported recently improved outcomes with allo-HCT. ...
Reference: Solid Tumours
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... These results illustrate the exacerbated inflammatory response to severe surgical and traumainduced tissue injury and the possibility of using these biomarkers especially PSEP for early prediction of oncoming septic complications. In line with these findings, multiple recent studies detected significantly higher perioperative serum PSEP levels in patients admitted to SICU and developed infectious complications after esophagectomy [17], liver transplantation [18], cardiac surgery [19], and gastrectomy [20], and these studies concluded that PSEP is a valuable early indicator for PO infectious complication's detection than leukocyte count, CRP and PCT. ...
... However, there is no favorable model to predict the prognosis of liver failure during pregnancy. Although MELD 12 is sometimes used to evaluate pregnant women with hepatobiliary-related diseases 13 such as liver dysfunction due to biliary atresia 14 and cirrhosis 15 , its e cacy is relatively limited, and the calculation is complicated. ...
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... Compared with the controversy of minimally invasive surgery for abdominal NB, minimally invasive surgery for thoracic NB has been more widely recognized [16][17][18]. At present, it has been suggested that thoracoscopic surgery can be used as a standard surgical method for mediastinal tumors, regardless of the degree of malignancy of the tumor [18][19], without the limitation of tumor size [20]. One reason is that many studies have shown that compared with abdominal NB, thoracic NB has better biological characteristics and is limited [21], so it can bring a better prognosis, so it is easier to accept even if it cannot be gross-total resected [19]. ...
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