Tatiana O. Kolesnikova's research while affiliated with Saint Petersburg State University and other places

... Mammalian neocortex (isocortex) controls multiple central nervous system (CNS) functions, including memory, speech, personality traits, behavior, emotions, motivation, perception, movement control, learning and consciousness (Jawabri and Sharma, 2022;Molnár et al., 2019). Neocortex also modulates the autonomic nervous system (ANS) that regulates cardiovascular, locomotor, gastrointestinal and respiratory processes via connections between the hypothalamus and cingulate gyrus (Costa et al., 2023b;Mizuno-Matsumoto et al., 2020). With six-layered horizontal subdivision (El-Drieny et al., 2015), neocortical major functional units are microcolumns, assembled in large groups and highly overlapping with each other to produce tight associative connections (Narayanan et al., 2017). ...

... Numerous studies demonstrate that grooming in mammals is an innate, preprogrammed behavior, consisting of fixed action pa erns generated in the brainstem and specified by a genetic program [36]. In rodents, grooming accounts for up to 30-50% of daily activity and rodent grooming follows a complex sequence from head to tail that is evolutionarily conserved [38]. Significantly, grooming behavior is not dependent on tactile sensory feedback, but is, instead, modulated by basal ganglia in various parts of the brain [36]. ...

... According to the recent World Health Organization (WHO), depression is a major global health problem with 3.8% of the population, of which 5-6% are adults older than 60 years [48]. Since the 1980s there has been strong interest in evaluating the relationship between depression and the immune system as it has been noted that inflammatory diseases, for example, rheumatoid arthritis and fibromyalgia, are accompanied by depression [47][48][49][50]. Finding confirmed the presence of abnormal cytokines and interleukins in depression that can modulate brain neurotransmission by bidirectionally influencing the hypothalamic-pituitary-adrenal/gonadal (HPA-G) axis and intestinal/vaginal microbiota [51][52][53]. ...

... Extensive research has delved into the intricate involvement of numerous genes and signaling pathways in the development of epilepsy (Perucca et al., 2020). Recognizing the pivotal role of genetic factors in epilepsy and its treatment, ongoing efforts utilize various genetic and genomic technologies to analyze the disorder's genetic foundations (Shevlyakov et al., 2023). Highthroughput sequencing analysis of gene expression, complemented by advanced bioinformatics tools, has emerged as a cutting-edge approach for investigating disease onset and progression, offering insights into the underlying mechanisms of epilepsy. ...

... Today, extensive molecular and genetic tools are available for zebrafish studies (also to model many human diseases) as they share similar genetic, endocrine, and physiological features to higher vertebrates [11]. Indeed, the zebrafish shares 70% of its genome and over 80% of disease-related proteins with humans [12] and has been used for studying the causal mechanisms of many human diseases as well as for finding new preventive and curative treatments [9,[12][13][14]. More than 10,000 researchers [15], belonging to 1595 labs and from 31 countries around the world [16], use zebrafish as animal models. ...

... Thus, alterations in brain signaling and behavior of zebrafish due to microbiota dysbiosis can be effectively analyzed using established protocols. Indeed, the utility of zebrafish as a powerful model system to screen numerous antimicrobial drugs based on their putative CNS effects has been reviewed (Kotova et al., 2023). Several investigations in rodents have shown that gut biota dysfunction is associated with stress response, locomotion changes, anxiety-like behavior, depression-like behavior, nociceptive responses and social behaviors (Wang et al., 2022a, b, c;Olorocisimo et al., 2023;Huang et al., 2023). ...

... Two excellent reviews by Allan Kalueff's group provide translational insights into epilepsy from zebrafish models [10,11]. One review discusses recent advances and current challenges in the development of experimental models of mTOR-dependent epilepsy and other related mTORopathies [10]. ...

... Two excellent reviews by Allan Kalueff's group provide translational insights into epilepsy from zebrafish models [10,11]. One review discusses recent advances and current challenges in the development of experimental models of mTOR-dependent epilepsy and other related mTORopathies [10]. ...

... 65−69 Capitalizing on the growing utility of zebrafish assays as a powerful in vivo drug screening platform, we have recently tested a battery of 10 novel N-benzyl-2-phenylethylamines (NBPEAs) with the 2,4-or 3,4-dimethoxy substitutions in the phenethylamine moiety and the −OCF 3 , −F, −Br, and −Cl substitutions in the ortho position of the phenyl ring of the Nbenzyl moiety. Testing their acute behavioral and neurochemical effects, we have previously identified four interesting neuroactive compounds for further analyses 70 (Figure 1), including two compounds with pronounced beneficial (anxiolytic/antidepressant-like) acute behavioral effects with increased brain serotonin and dopamine turnover (N-(2trifluoromethoxybenzyl)-2-(2,4-dimethoxyphenyl)ethylamine, 24H-NBOMe(F)) and N-(2-trifluoromethoxybenzyl)-2-(3,4dimethoxyphenyl)ethylamine, 34H-NBOMe(F)), one compound with anxiogenic-like profile but no overt neurochemical profiles (N-(2-fluorobenzyl)-2-(3,4-dimethoxyphenyl)ethylamine, 34H-NBF) acutely, and a behaviorally inert compound with overt neurochemical activity similar to 24H-NBOMe(F) and 34H-NBOMe(F), N-(2-chlorobenzyl)-2-(3,4dimethoxyphenyl)ethylamine (34H-NBCl). Their ability to cross the zebrafish blood-brain barrier and enter the brain as well as chemical synthesis, chemical structures, and analytical data have already been reported previously. ...

... Despite that previous zebrafish models of exposure to chronic stress have been described, the neurobehavioural description is rather scarce, with only a handful of studies presenting some information about the behavioural effects of stress in zebrafish models, while many others hypothesise their efficacy (14,15,16,17). Moreover, as oxidative stress was previously demonstrated as a major component of the processes comprising the response to stress, the description of the oxidative parameters variation in stressful conditions is limited, with regards to the zebrafish models of chronic stress exposure (18). ...