Tao Liu's research while affiliated with First Affiliated Hospital of China Medical University and other places
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Publications (3)
Gene-edited pig-to-human xenotransplantation continues to make breakthroughs and is expected to enter clinic to solve the global shortage of donor organs. However, which gene combination is suitable for which organ transplantation remains unclear. In this study, we utilized CRISPR/Cas9 gene editing technology, PiggyBac transposon system and somatic...
During the initial stage of liver regeneration (LR), hepatocytes and liver sinusoidal endothelial cells (LSECs) initiate regeneration in a hypoxic environment. However, the role of LSECs in liver regeneration in hypoxic environments and their specific molecular mechanism is unknown. Therefore, this study aimed to explore the miRNA–mRNA network that...
Allogeneic kidney transplantation (renal allograft) is the most effective treatment for advanced kidney disease. Previous studies have indicated that ferroptosis participates in the progression of acute kidney injury and renal transplant failure. However, few studies have evaluated the prognostic value of ferroptosis on renal transplantation outcom...
Citations
... Our previous study revealed that, under hypoxic culture conditions, LSECs maintained fenestration and proliferated via regulation of the SENP1/HIF-1α/VEGF signaling pathway (17,28). Thus, SENP1 has been suggested to be involved in regulating the maintenance of a healthy LSEC phenotype under hypoxic conditions, assisting LSEC function in promoting liver regeneration. ...
... CDKN1A acts as a cell cycle regulator involved in genome stability, and low expression of CDKN1A contributes to poor prognosis in chromophobe renal cell carcinoma (Ohashi et al., 2020). CDKN1A has been shown to be a member of ferroptosis-associated signature genes to predict graft loss after renal allograft transplantation (Fan et al., 2021). Moreover, the prognosis of KIRP patients can also be accurately predicted by the risk model constructed by using CDKN1A as a ferroptosis-related gene signature (Da et al., 2022). ...
