Ta Xiao's research while affiliated with China Academy of Chinese Medical Sciences and other places
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Publications (30)
Background
Malignant transformation of the epidermis is an essential process in the pathogenesis of cutaneous squamous-cell carcinoma (cSCC). Although evidence has demonstrated that CD147 plays key roles in various tumors, the role of CD147 in epidermal malignant transformation in vivo remains unclear.
Methods
Epidermal CD147-overexpression or kno...
A Correction to this paper has been published: https://doi.org/10.1038/s41388-021-01641-8
Following the publication of the above article, the authors have realized that one of the data panels featured in Fig. 5D was selected incorrectly. Specifically, the wrong image was selected for the A1 (28‑30), HCT116 experiment. The authors have revisited their original sources to identify the correct data panel, and can confirm that the error aro...
Long non-coding RNAs (lncRNAs) represent an important class of RNAs comprising more than 200 nucleotides, which are produced by RNA polymerase II. Although lacking an open reading framework and protein-encoding activity, lncRNAs can mediate endogenous gene expression by serving as chromatin remodeler, transcriptional or post-transcriptional modulat...
EphA2 (EPH receptor A2) (erythropoietin‑producing hepatocellular receptor tyrosine kinase subtype A2) plays a crucial role in human cancers, and is a promising target for the development of new anticancer drugs. In this study, we showed that the interaction of Annexin A1 (ANXA1) and EphA2 increased EphA2 stability by inhibiting its proteasome degra...
Abstract Eph receptors and the corresponding Eph receptor-interacting (ephrin) ligands jointly constitute a critical cell signaling network that has multiple functions. The tyrosine kinase EphA2, which belongs to the family of Eph receptors, is highly produced in tumor tissues, while found at relatively low levels in most normal adult tissues, indi...
EphA2 is an important oncogenic protein and emerging drug target, but the oncogenic role and mechanism of ligand-independent phosphorylation of EphA2 at tyrosine 772 (pY772-EphA2) is unclear. In this study, we established nasopharyngeal carcinoma (NPC) cell lines with stable expression of exogenous EphA2 and EphA2-Y772A (phosphorylation inactivatio...
Overexpression of ANXA1 and EphA2 has been linked to various cancers and both proteins have attracted considerable attention for the development of new anticancer drugs. Here we report that ANXA1 competes with Cbl for binding EphA2 and increases its stability by inhibiting Cbl-mediated EphA2 ubiquitination and degradation in nasopharyngeal carcinom...
CD147, also known as extracellular matrix metalloproteinase inducer (EMMPRIN), is a transmembrane glycoprotein that is highly expressed in tumor cells, particularly melanoma cells, and plays critical roles in tumor cell metastasis through the regulation of matrix metalloprotease (MMP) expression. In this study, we identified Fyn as a novel interact...
HDAC7 plays a crucial role in cancers, and is the main drug target of several HDAC inhibitors. However, the role and mechanism of HDAC7 in nasopharyngeal carcinoma (NPC) are still unclear. In this study, we observed that HDAC7 was significantly upregulated in the NPC tissues relative to normal nasopharyngeal mucosa (NNM) tissues, HDAC7 expression l...
Our phosphoproteomics identified that phosphorylation of EphA2 at serine 897 (pS897-EphA2) was significantly upregulated in the high metastatic nasopharyngeal carcinoma (NPC) cells relative to non-metastatic NPC cells. However, the role and underlying mechanism of pS897-EphA2 in cancer metastasis and stem properties maintenance remain poorly unders...
Annexin A1 (ANXA1) is dysregulated in the various tumors. However, the role and mechanism of ANXA1 in the cancers are poorly understood. In this study, we first showed a clinically positive correlation between ANXA1 and autophagy-associated protein SQSTM1 expression in nasopharyngeal carcinoma (NPC) and ANXA1-regulating SQSTM1 expression through au...
RACK1 is upregulated in the various types of human cancers, and considered to play a role in the development and progression of human cancer. However, the role and mechanism of RACK in the colon cancer are poorly understood. In this study, we detected RACK1 expression in 63 normal colonic mucosa, 60 colonic inflammatory polyps, 60 colonic adenomas,...
TRAF6, a well-known adapter molecule, plays pivotal role in TLR/IL-1R associated signaling pathway. Although TRAF6 has been shown to have oncogenic activity in various malignant tumors, the details remain unclear. In this study, we demonstrated that TRAF6 facilitates Ras (G12V) and EGF-induced cellular transformation through EGFR. Silencing of TRAF...
Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment, but little is known about how miRNA regulates this phenomenon. In this study, we investigated the function and mechanism of miR-125b in NPC radioresistance, one of upregulated miRNAs in the radioresistant NPC cells identified by our previous microarray analysis. We...
MiR-125b is aberrantly expressed and has a role in the various types of tumors. However, the role and mechanism of miR-125b in nasopharyngeal carcinoma (NPC) are unclear. In this study, we investigated the role and mechanism of miR-125b in NPC. We observed that miR-125b was significantly upregulated in the NPC tissues relative to normal nasopharyng...
Raf kinase inhibitory protein (RKIP) functions as a chemo-immunotherapeutic sensitizer of cancers, but regulation of RKIP on tumor radiosensitivity remains largely unexplored. In this study, we investigate the role and mechanism of RKIP in nasopharyngeal carcinoma (NPC) radioresistance. The results showed that RKIP was frequently downregulated in t...
Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment. Clinical tumor-node-metastasis (TNM) staging has limited accuracy in predicting NPC radioresponse and determining its therapeutic regimens. To construct a risk score model for predicting NPC radioresistance, immunohistochemistry was used to assess the expression of...
Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment, but little is known about how miRNA regulates this phenomenon. In this study, we investigated the function and mechanism of miR-203 in NPC radioresistance, one of downregulated miRNAs in the radioresistant NPC cells identified by our previous microarray analysis. W...
Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment, but little is known about how miRNA regulates this phenomenon. In this study, we investigated the function and mechanism of miR-23a in NPC radioresistance, one of downregulated miRNAs in the radioresistant NPC cells identified by our previous microarray analysis. W...
The role and underlying mechanism of Raf kinase inhibitory protein (RKIP) in nasopharyngeal carcinoma (NPC) metastasis remain unclear. Here, we showed that RKIP was downregulated in the NPC with high metastatic potentials, and its decrement correlated with NPC metastasis and poor patient survival, and was an independent predictor for reduced overal...
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in southern China and southern Asia, and poses one of the most serious public health problems in these areas. Early diagnosis, predicting metastasis, recurrence, prognosis and therapeutic response of NPC remain a challenge. Discovery of diagnostic and predictive biomarkers is...
Citations
... After newborn nude mice were injected with MDCK cells, the tissue characteristics were similar to adenocarcinoma, and the tumours could migrate, forming lung metastasis and spinal cord metastasis [27]. Spontaneous malignant transformation is an important trigger of tumorigenesis, and this process has been found to be associated with the abnormal expression of some key molecules, such as p53[28], EGFR [29], CD147 and RSK2 [30]. The mechanism of spontaneous tumorigenesis in continuous cell lines in vitro is different from that of induced tumorigenesis [23]. ...
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... FYN was found to regulate autoimmunity by binding to B-lymphocyte surface antigen CD19 [49] and interacting with immunoglobulin superfamily member CD147 [50]. Evidence has shown that FYN plays a role in cancer pathogenesis and drug resistance [51]. ...
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... Compared with laboratory experiments, bioinformatics technology has a great advantage in collating, analyzing, and visualizing large amount of biological information quickly and accurately by computer, with a good reproducibility [13]. Biomarkers and therapeutic targets of many diseases as well as tumors were identified by bioinformatics [14][15][16]. In this study, AR-related public datasets (GSE75011, GSE46171) were downloaded from Gene Expression Omnibus (GEO) database, and weighted gene co-expression network analysis (WGCNA) was performed to gain AR-related genes (ARRGs). ...
... By implementing this methodology, MYC and ATF5-derived CPPs were shown to restrict tumor growth and have now progressed to clinical trials [5][6][7][8][9][10][11]. In line with the above studies, dominant-negative domains of ANXA1, p50, connexin-43, and Grb-7 were shown to inhibit gastric and colon cancers [12], breast cancer [13], glioma [14], and human epidermoid carcinoma [15]. The U.S. Food Drug Administration has authorized 15 peptide-based drugs in recent years [16]. ...
... ALW-II-41-27 is a small-molecule inhibitor that has been demonstrated to selectively bind to the ATP-binding pocket of the EphA2 receptor kinase domain (13). Although the compound has been shown to have EC 50 values on a number of kinases in vitro at 10 uM (including CSF1R, DDR1/2, Kit, Lck, and PDGFRα/β) (14), this and other recent studies show EC 50 effects of the inhibitor at 200 nM or less on EphA2 kinase activity, allowing more directed and targeted therapeutic dosing (14)(15)(16). ...
... Ephrin receptor A2 (EphA2), a 130 kDa transmembrane glycoprotein, is a member of the Ephrin receptor family, which is the most famous class of receptor tyrosine kinases (RTKs) [23]. Although the role of other members of the Eph family has also been explored in tumours, EphA2 is extremely arresting [24]. ...
... ANXA1 has been extensively implicated in the progression of various cancers. Previous studies have demonstrated its regulatory role in promoting growth and metastasis in nasopharyngeal carcinoma (Feng et al. 2020) and lung cancer (Cai et al. 2018). Additionally, ANXA1 has been shown to promote PTC growth via MYC (Ying et al. 2021) and enhance PTC proliferation and migration through the IL-6/ JAK2/STAT3 pathway (Zhao et al. 2021). ...
... 31 HDAC7 has been reported to promote the proliferation, migration, and invasion of nasopharyngeal carcinoma by downregulating miR-4465 and upregulating EphA2. 32 Silencing HDAC7 in glioblastoma resets the tumor suppressor activity of STAT3. 25 Additionally, miR-489 has been found to target HDAC7, thereby suppressing tumor growth and invasion in CRC. ...
... FYN was a nonreceptor tyrosine kinase (RTK) member of the Src family kinase (SFK) (55). It was reported that FYN promoted tumor progression in glioma (56), melanoma (57), colon cancer (58), gastric cancer (59), and pancreatic cancer through various mechanisms (60). Furthermore, FYN was found to suppress LUAD by downregulating PI3K/AKT and inhibiting the epithelial-tomesenchymal transition (61). ...
... Phosphorylation of serine/threonine residues in Eph receptors can trigger ligand-independent signalings, as exemplified by S897-phosphorylated EphA2, which activates AKT and PI3K, promoting the migration and invasion of cancer cells. A mutation at the S897 site abolishes the ligand-independent promotion of cell motility [11,106]. Ligand-independent EphB1 signaling promotes lung cancer cell invasion and migration through CDH2-induced EMT [41]. ...
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