T Müller's research while affiliated with University Hospital Regensburg and other places

... For each specimen, imaging was carried out with high-resolution confocal laser scanning microscopy. First, the membranes were searched for predilection sites with increased cell adherence that have been previously defined [8,12]. Nodal points of the warps, or stitches, connecting the hollow fibers and contact points of adjacent hollow fibers were identified. ...

... 38 All ECLS techniques leverage a gas exchange device, referred to as the oxygenator or artificial lung, to provide different degrees of oxygenation, carbon dioxide removal, and circulatory support. 39 While many forms of ECLS have been used as a BTLT in patients with ESLD, 19,40,41 ECMO is by far the most common 42,43 and is the focus of this article. ECMO uses vascular access cannulas, a mechanical pump, and an oxygenator to pump venous blood from the patient via negative pressure and return the blood to the patient via positive pressure after gas exchange has occurred. ...

... 1,2 A combination of factors determines that ECMO patient mortality rates are significant. [3][4][5] These include the fact that patients qualifying for ECMO cannulation are already in an unstable and critical condition, the invasive nature of the procedure involved (generally jugular or femoral venous and/or arterial cannulation), and the potential physiologic or mechanical complications associated with ECMO. An international study showed that hospitals with higher volumes of ECMO patients achieved lower mortality rates than facilities that were dealing with fewer ECMO cases. ...

... Furthermore, unspecific protein binding to the membrane gradually reduces the efficiency of gas exchange. Both aspects are ascribed to the low hemocompatibility of the gas permeable membranes that are in direct contact with the blood [3,4,[13][14][15][16]. ...

... There are diverse underlying diseases causing terminal situations of gas exchange such as including sepsis, trauma, asphyxia, drowning, fat embolisation, pneumonia and other reasons of pulmonary failure with and without cardiac weakness. The amelioration of the percutaneous technique by 'Seldinger' for application of appropriate cannulae has mainly contributed to simplification of the complete technique, such as vascular access allows the application of a pumpless lung assistance by arterio-venous shunt under all possible circumstances such as emergency transportation, intensive care in different medical and emergency units [6]. An arterio-venous shunt up to two liters/min demands for increase of cardiac output in another wise cardiac healthy individuums well tolerated for weeks [2]. ...

... ,26 Krivitski et al. describe dpMO monitoring alone as inaccurate, explaining that the increase in dpMO depends rather on thrombus location than size, 20 which is supported by Lehle et al. stating that increasing dpMO is a rare device related indicator of MOT.21 Consequently, we presume that the large difference in maximum dpMO of both Neo2 and Neo3 experiments could be a result of different thrombus locations and geometries. We ascribe the final ...

... Therefore, patients who are already physiologically compromised must be transported to a distant area for an extended period of time and isolated from their usual caregivers. (Stevenson 2002, Waydas 1999, PA-PSRS, 2005. Improvements in technology and the wide range of diagnostic capability available with a CT scan make it a frequent choice for imaging. ...

... Wilm et al. showed that cellular deposits on PMP membranes mainly consist of leukocyte cells and Von Willebrandpositive endothelial cells. 3 Due to clinical pressures, we were unable to carry out an autopsy of the oxygenator used in this patient, which would have yielded more information. ...

... Gemäß dem Hagen-Poiseuille-Gesetz (V = π×r4×Δp 8×η×l ) sollte die Kanüle so kurz, aber so großkalibrig wie möglich sein. Die klassische Variante der Anlage umfasst die Punktion der rechtsseitigen V. femoralis, um die abführende Kanüle (21)(22)(23)(24)(25) in der V. cava inferior zu platzieren, und die Punktion der rechtsseitigen V. jugularis interna (Kanüle 17-21 Fr), um das Blut in die V. cava superior zurückzuführen [5]. Die Spitzen der beiden Kanülen sollten etwa 20 cm auseinander liegen, um eine Rezirkulation des oxygenierten Blutes so gering wie möglich zu halten (s. ...

... 46 Bein t et al. performed a retrospective multivariate analysis on 40 patients with arDs who underwent aV-ecco2-r and moderate hypercapnia (PaCO2≤55 mmHg). 47 During spontaneous breathing, high sweep gas flows and high blood flows decreased spontaneous tidal volumes supporting lung protection. ...