T Kikuchi's scientific contributions
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Publications (5)
Anti-hepatitis C virus immunoglobulin M antibody titers were measured by enzyme-linked immunosorbent assay in 28 patients with chronic hepatitis C. Nine patients were treated with alpha-interferon at a dosage of 3 MIU/day for 4 weeks. Anti-HCV IgM was positive in 12 of the 28 patients, and these 12 patients also had significantly higher anti-HCV an...
The lymphocyte subpopulations in the peripheral blood and liver were studied in 17 patients with chronic active hepatitis type C (CAH C) by immunoenzymatic and immunofluorescence techniques, using mono-specific T cell antibodies and other reagents. The peripheral blood subsets showed no significant differences between the patients with CAH C and no...
To clarify the relationship between autoimmune hepatitis (AIH) and the hepatitis C virus (HCV), we investigated the prevalence of antibodies to HCV (anti-HCV) by an enzyme-linked immunosorbent assay in patients with AIH, primary biliary cirrhosis (PBC), rheumatoid arthritis and multiple myeloma. The antibody was detected in 9 out of 18 patients wit...
We examined peritoneoscopic findings of six patients with severe type of acute hepatitis, then compared it with eight patients with fulminant hepatitis. There were no liver atrophy in peritoneoscopic findings in patients with severe type of acute hepatitis, whereas two patients with fulminant hepatitis showed liver atrophy. There were various types...
Citations
... Similar properties, such as antitumor [36], anti-inflammation, antibacterial [37], anti-oxidation [38], antifibrosis and scavenging free radicals [39] were also discovered for rhein. Scoparone, geniposide and rhein are considered the main bioactive compounds of Yin-Chen-Hao-Tang and their synergistic effects contribute to the therapeutic purpose of YCHT reported for treating liver fibrosis [40], primary biliary cirrhosis [41], cholestasis, hepatitis [35], or pancreatic carcinoma [42]. Despite the crucial properties, seldom articles have simultaneously investigated these three bioactive compounds of YCHT. ...
... Ces résultats donnent à penser que, comme dans l'HF due au l'HBV, l'HF due au HCV pourrait induire une immunité humorale forte et rapide. (4) reported that IgM response was not observed or was weak in acute HCV infection. We investigated the IgM response with the use of a third generation assay system of anti-HCV, which has good sensitivity, and reassessed the clinical significance of IgM anti-HCV in acute hepatitis (AH). ...
... In the present study, we detected a significant upregulation of ions, including Fe ++ , Ca ++, and Mg ++, in patients diagnosed with HCV hepatitis. The absence of K + and LDH release in the perforated or the extracellular compartment suggests that the release of Mg ++ induced by ethanol occurs through the operation of a specific transport process (Onji et al., 1992). A significant decrease in the K + ion concentration in sera of the patients has suggested its role and is in agreement with previous findings. ...
... The discrepancies in HCVAb levels reported in the different studies could be explained by different patient selection methods or by epidemiological and/or genetic factors. An increased frequency of false-positive tests for HCV due to the presence of R F or hypergammaglobulinaemia has been demonstrated by some authors in rheumatoid arthritis and chronic liver diseases [40,41]. Other studies did not confirm this phenomenon in MC, nor in rheumatoid arthritis and Sjogren's syndrome [5,37,42,43]. ...
Reference: Hepatitis C Virus and Mixed Cryoglobulinemia
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