Stella Pelengaris's research while affiliated with The University of Warwick and other places

... It outperformed state-of-the-art existing studies as shown in Table 6. Jaccard index and F1 score of the model are compared with U-Net [54], UNetþþ [55], DIST [33], MicroNet [56], ASPP Unet [40], SCPP-Net [57], Nuclei-SegNet [39], DenseRes-Unet [15], and DAN-NucNet [18]. The DAN-NucNet [18] is the second high performing model which has 0.84 F1 score and 0.74 Jaccard index. ...

... Xu et al. [23] proposed a multi-channel deep learning architecture in which three separate deep learning models were used to perform colon gland segmentation task and combined the results of different channels through a fusion network. Raza et al. [24] proposed the MIMO-Net, which has multiple-input and multiple-output for instance segmentation of colon glands. Furthermore, Yang et al. [25] proposed a deep active learning framework for the instance segmentation task using limited gland labels. ...

... The different performance of our network with different designs on NH-haze2023 dataset. Bolded indicates the best performanceSingle input Multi-scale inputMulti-scale output[44] Single-scale output Normal resblock[45] Res FFT-conv[46] Ours FLBlock ...

... Although the precise means by which DHA promotes these phenotypes remains to be determined, it appears to destabilize Myc protein by promoting its ubiquitin-dependent proteasomal degradation [28,45]. Because many tumors have been proposed to be dependent upon or "addicted" to high-level Myc expression [46,47], its loss may selectively impair their survival. ...

... A 2014 systematic review (Walker et al., 2014) examining the treatment of depression in cancer patients only identified 7 publications that met the inclusion criteria. Two of the studies examined the effect of pharmacologic therapies (Pezzella et al., 2001;Costa et al., 1985) and 1 explored pharmacologic versus psychologic treatment effects (Veitenhansl et al., 2004). Recently, the relationship between depression and inflammation was explored in cancer patients treated for depression. ...

... The total mass of β-cells changes over time: it continues to do so during adult life and it has become apparent during the past decade that the pathogenesis of both type 1 and type 2 diabetes involves failure to maintain an appropriate β-cell mass (Bonner- Weir, 2000;De León et al., 2003;Lee et al., 2006;Steil et al., 2001). The total mass is the combined result of three processes: proliferation (cell division), apoptosis (programmed cell death), and neogenesis (regeneration from a pool of rapidly dividing cells, which themselves derive from pluripotent stem cells, or possibly de-differentiated β-cells, or alternatively trans-differentiated pancreatic cells); these processes are influenced by the levels of both glucose and insulin (Beith et al., 1998;Bouwens and Rooman, 2005;Dor et al., 2004;Efanova et al., 1998;Johnson and Alejandro, 2008;Lipsett and Finegood, 2002;Rooman et al., 2002;Young et al., 2008). As a result, there is an interplay between the fast, ultradian fluctuations of glucose and insulin and the slower (>days) changes in β-cell mass. ...

... Additionally, to explore CKE effect on c-MYC expression in DMBA/TPA induced mice, we performed IHC and qPCR analysis of Skin and tumor tissue obtained from all grouped mice. According to reports, the development of SSC is influenced by the activation of protooncogenes like c-MYC overexpression and/or the inactivation of tumor suppressor genes like p53 mutation (34,(40)(41)(42)(43). c-MYC was one of the first oncogenes to be identified as being involved in the development of cancer. ...

... Blood glucose levels increased from Day 2, peaking at >25 mmol/l on Day 7. Blood glucose levels fell rapidly following Myc deactivation and were largely normalised at 3 weeks, by which time glucose levels were identical to those of wild-type littermates. Glucose levels remained slightly above mean pre-treatment levels, which, as previously shown, are generally slightly lower than average for wild-type mice [33]. Importantly, transgenic and wild-type mice had an essentially normal response to glucose tolerance tests on Days 26 and 57 (3 weeks after c- Myc was 'switched off') (ESMFig. ...

... IGF-II, a known mitogen, is structurally related to insulin and may contribute to expansion of the β-cell population in times of need (e.g. during diabetes, obesity or pregnancy) [6][7][8][9][10]. The bioactivities of insulin, IGF-II and IGF-I are mediated via interaction with one or more members of a closely-related family of receptors; the insulin receptor (IR), which exists in two isoforms (A and B), and the IGF type-1 receptor (IGF1R). ...

... Human and mouse C-MYC is expressed ubiquitously during development in growing tissues, and in adult tissue compartments possessing high proliferative capacity (e.g. skin epidermis and gut), however it is undetected in cells that have exited the cell cycle (Semsei et al., 1989;Mattsson et al., 2006). The expression of human and mouse NANOG was also demonstrated in a variety of somatic cells (Hart et al., 2004;Ambady et al., 2010). ...