Sruthi Sarvepalli's research while affiliated with St. John's University and other places
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Publications (2)
Most lung cancer instances are non-small cell lung cancers (NSCLC). As stated by recent literature, cycloxygenase-2 (COX-2) is upregulated in lung adenocarcinomas. COX-2 relates to enhanced cell proliferation and reduced apoptosis; both of which are essential for an invasive tumor growth and metastasis. Thus, COX-2 inhibition forms an important che...
Applicability of hydrogels as drug delivery systems is on the rise due to their highly tunable degree of polymeric crosslinking to attain varying rates of payload release. Sustaining the release of therapeutic payloads at certain physiological sites has been the need of the hour to treat disorders such as peritoneal or pleural malignancies. These d...
Citations
... Several drug delivery strategies have been developed using modern inhalation devices such as dry powder inhalers (DPI) and metered dose inhalers (MDI) with major focus on aerodynamic particle size distribu-tion and dose uniformity [6]. Other techniques include nano-and micro-particles [7][8][9], porous particles [10], liposomes [11], lipid based formulations [12,13], most of which are developed as a measure to improve the bioavailability of the drug [14]. However, these strategies solve only a part of the problem with insufficient emphasis on rapid elimination of the particles by lungs' defense mechanisms, short halflife, and poor patient compliance. ...
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... However, the shear thinning process may disrupt chemical bonds, potentially affecting viral retention crucial for the application of scaffold-mediated lentiviral transduction. While on-site crosslinking biomaterials have been used for cell delivery towards cartilage defect and other intracavitary applications [33,34], their incomplete gelation may lead to leakage of polymer solution towards off-target sites. Therefore, scaffolds with defined geometry have been explored for various applications such as tissue engineering, and delivery of biological factors and cells [35]. ...
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