Song Zou's research while affiliated with Sichuan University and other places
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Publications (12)
Interleukin 37 (IL‐37), a member of the IL‐1 family, is considered a suppressor of innate and adaptive immunity and, hence is a regulator of tumor immunity. However, the specific molecular mechanism and role of IL‐37 in skin cancer remain unclear. Here, we report that IL‐37b‐transgenic mice (IL‐37tg) treated with the carcinogenic 7,12‐dimethylbenzo...
Interleukin-37b (hereafter called IL-37) was identified as fundamental inhibitor of natural and acquired immunity. The molecular mechanism and function of IL-37 in colorectal cancer (CRC) has been elusive. Here, we found that IL-37 transgenic (IL-37tg) mice were highly susceptible to colitis-associated colorectal cancer (CAC) and suffered from dram...
Patients with psoriasis tend to have significant comorbidities, such as hyperlipemia, diabetes mellitus, and obesity, which belong to metabolic disorders. The specific mechanism through which psoriasis increases the metabolic disorder risk is uncertain. In this study, we demonstrated that the dysbiotic gut microbiota of 6-month-old psoriasis-like m...
Background:
Although outflow tract (OT) ventricular arrhythmias (VAs) are generally regarded as benign, the relationship between circulation pressure and VAs has received considerable attention in recent years. Previous studies have shown that the ratio of main pulmonary artery (MPA) to ascending aorta (AA) diameter is associated with pulmonary pr...
Aims:
After myocardial infarction (MI), injured cardiomyocytes recruit neutrophils and monocytes/macrophages to myocardium, which in turn initiates inflammatory and reparative cascades, respectively. Either insufficient or excessive inflammation impairs cardiac healing. As an endogenous inhibitor of neutrophil adhesion, EDIL3 plays a crucial role...
Psoriasis is an immune-mediated systemic disease with associated comorbidities, including metabolic syndrome (MetS) which contributes substantially to premature mortality in patients with psoriasis. However, the pathological mechanisms underlying this comorbidity are unclear. Studies have shown that the pathological parameters of psoriasis mediate...
Patients with psoriasis tend to have significant comorbidities, such as hypertension, diabetes mellitus and obesity, which belong to metabolic disorder. The specific pathways through which psoriasis increases metabolic disorder risk is uncertain. The gut microbiome and gut associated metabolites as important regulators of host energy and substrate...
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Background and objective:
Systematically review the current published literature on the impact of exercise training (ET) in chronic heart failure (CHF) patients who were conducted cardiac resynchronization therapy (CRT).
Methods:
PubMed, EMBASE, and the Cochrane Library of Controlled Trails databases were searched for trials comparing the additi...
Introduction:
Hemodynamically-instable ventricular arrhythmias (VAs) are rare in patients with pulmonary hypertension (PH). To the best of our knowledge, only 1 case has been reported so far. Moreover, the pathogenesis of this kind of arrhythmia remains obscured and its treatment is challenging. Here we report another case and presented the substr...
PurposeIn radiofrequency ablation near coronary arteries (CA), coronary angiography is traditionally recommended to estimate distance between catheter and CA. This study aimed to investigate the feasibility of an alternative approach for intuitively demonstrating spatial location of catheter and CA during ablation of ventricular arrhythmias (VAs) o...
The precise mechanism through which macroautophagy/autophagy affects psoriasis is poorly understood. Here, we found that keratinocyte (KC) autophagy, which was positively correlated with psoriatic severity in patients and mouse models and could be inhibited by mitogen-activated protein kinase (MAPK) family inactivation. The impairment of autophagic...
After myocardial infarction (MI), injured cardiomyocytes recruit neutrophils, leading to extravasated monocytes polarized to inflammatory and reparative macrophages sequentially, which contribute to the healing and regenerative process. As an endogenous leukocyte-endothelial adhesion inhibitor, the role of EDIL3 in MI remains obscure. We found that...
Citations
... 34 In carcinogenic 7.12-dimethylbenzoanthracene/12-o-tetradecylphorbol-13-acetate-induced skin cancer mice, overexpressing IL-37 (IL-37tg mice) downregulated expression of CD80, CD86, CD40, CC chemokine receptor 7 (CCR7), CXCL9, CXCL10 in CD103 + DCs. 35 When CD103 + DCs from IL-37tg mice were cultured with poly(I:C), there were reduced levels CD40. Addition of IL-37 inhibited extracellular acidification rate, decreased glycolysis. ...
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... On the other hand, Parabacteroides distasonis, which increased occurrence in the control, was another potential key player of psoriasis. This observation was also recapitulated by other groups previously in the mice model and a population other than southern Chinese [31,[60][61][62]. It has been reported to possess anti-inflammatory properties, with emerging in vitro and in vivo evidence to alleviate colonic inflammation [63][64][65][66]. ...
... Based on universal cell markers, we annotated the 0 cluster as T helper cells due to their high expression of CCR6 and RORA; annotated the 1 cluster as NK T cells due to their high expression of NKG7 and ITGB2; annotated the 2 cluster as cytotoxic T cells due to their high expression of CD8A, CD8B, and CCL5; annotated the 3 cluster as exhausted T cells due to their high expression of LAG3 and CTSW; annotated the 4 cluster as Treg cells due to their high expression of CD4, TNFRSF4, and CORO1B; annotated the 5 cluster as naive T cells due to their high expression of CCR7 and SELL (Fig. 4B-D). The analysis of cell proportions revealed a signi cant reduction in the proportion of cytotoxic T cells and a signi cant increase in the proportion of exhausted T cells in CRC tissues compared to normal colorectal tissue, consistent with previous ndings (Fig. 4E) [43][44]. The results of pathway enrichment analysis for highly expressed genes showed a signi cant enrichment of ATP-related pathways and a signi cant downregulation of immune-related pathways in exhausted T cells compared to cytotoxic T cells, indicating a dysregulation of both the metabolic pathways and immune function in exhausted T cells (Fig. 4F-G). ...
... Over the last 20 years, there has been a growing body of research on the physiological properties of neural epithelial cells (NETs) and their impact on a wide range of disorders [308][309][310][311][312]. NET formation involves the uncoiling of DNA strands in response to stimuli, facilitated by proteases, such as peptidyl arginine deiminase 4 (PAD4) and neutrophil elastase (NE) [313][314][315][316][317][318]. Neutrophils extrude their contents through blebbing from the cell membrane while remaining alive and retaining their functional capabilities [307]. ...
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... Kết quả này tương tự với quan sát trong nghiên cứu của tác giả Trương Lê Tuấn Anh và cộng sự [10]. Độ tuổi có liên quan đến hội chứng chuyển hoá ở bệnh nhân vảy nến, đặc biệt là người cao tuổi (Bảng 1); tuổi càng cao sẽ làm tăng nguy cơ mô ngoại biên kém nhạy với insulin, kết hợp với tổn thương do các yếu tố tiền viêm gây ra làm tăng nguy cơ hội chứng chuyển hoá [8]. Trường hợp bệnh vảy nến khởi phát sớm cũng có cùng cơ chế: nguy cơ xuất hiện hội chứng chuyển hoá sẽ cộng dồn ở những bệnh nhân này [8]. ...
... For example, patients with cardiac resynchronization can be considered as a separate study direction in QoL assessment. Guo et al. [35] found that in CHF patients undergoing cardiac resynchronization therapy, non-HIIT significantly improved maximal workload by 26.32 W, exercise duration by 68.95 s, peak oxygen uptake (VO2) by 3.05 mL/kg/min, left ventricular ejection fraction (LVEF) by 4.97%, and HRQoL, with a notable decrease in MLHFQ scores by 19.96. In contrast, Tegenge et al.'s broader analysis across various ExCR delivery modes showed VO2peak improvements following center-based (3.10 mL/kg/min), home-based (2.69 mL/kg/min), and technology-enabled ExCR (1.76 mL/kg/min), alongside reductions in HF-related hospitalization and mortality risks only after center-based ExCR (OR = 0.41 for hospitalization and OR = 0.42 for mortality) [36]. ...
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... The PA:Ao ratio has been shown to be associated with various clinical conditions such as the presence and severity of pulmonary hypertension, 11 right ventricular outflow tract arrhythmias, 12 and prognosis of advanced heart failure. 13 Additionally, the PA:Ao ratio has been shown to be correlated with clinical outcomes in patients with There are no studies in the literature examining the relationship between the Lp(a) levels measured at the time of diagnosis and the PA:Ao ratio in survivors of COVID-19 within 3 to 6 months. ...
... 5,7,10 However, it is seldom reported for LV mapping and ablation. 11,12 Unlike the left atrium, LV exhibits more complex anatomy such as tendons, PMs or muscular pectinate. When mapping catheter roving around, bumping-induced contraction tends to create a false space. ...
... HMGB1 contributes to inflammation by inducing proinflammatory responses through Toll-like receptor 4 (TLR4). Additionally, the release of HMGB1 through autophagy in keratinocytes promotes skin inflammation in psoriasis [91,92]. The keratinocytes in the skin lesions of psoriasis model mice showed increased HMGB1 expression. ...
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