Sirisha Senthil's research while affiliated with L V Prasad Eye Institute and other places
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Publications (159)
Purpose
To analyze the intraoperative challenges of cataract surgery in children, following glaucoma filtering surgery.
Methods
This was a retrospective study to analyze intra-op challenges and outcomes of pediatric cataract surgery in post-glaucoma filtration surgery eyes, between January 2007 and December 2019.
Results
We included 20 eyes of 16...
Purpose
To report outcomes of Gonioscopy - assisted Transluminal Trabeculotomy(GATT) in eyes with prior failed glaucoma surgery.
Patients and Methods
A retrospective study involving 30 eyes of 30 patients, all of whom had open angles on gonioscopy, experienced prior glaucoma surgery failures, and subsequently underwent GATT. The primary outcome me...
Background:
GAPO syndrome is a rare autosomal recessive disorder characterized by the acronym of growth retardation, alopecia, pseudo-anodontia and progressive optic atrophy. While the genetic alteration of the ANTXR1 gene has been known for its cause, the full range of its clinical and genetic manifestations is not well explored due to the syndro...
The authors describe a case of reverse pupillary block with pigment dispersion following sequential phakic intraocular lens (pIOL) implantation for high myopia, in a young female patient. The intraocular pressure (IOP) elevation began 3 weeks postoperatively, for which Nd-YAG laser peripheral iridotomies (PIs) were attempted elsewhere. Despite maxi...
Purpose
This study introduces the Order of Magnitude (OM), a cost-effective, indigenous, virtual reality-based visual field analyzer designed for detecting glaucomatous visual field loss.
Methods
The OM test employs a two-step supra-thresholding algorithm utilizing stimuli of 0.43°diameter (equivalent to Goldmann size III) at low and high threshol...
We present a case of a 32-year-old male who came with the history of blurring of vision in both eyes. Diagnosed as a glaucoma suspect at another centre, he had a best corrected visual acuity (BCVA) of 20/20 in both eyes and there was no relative afferent pupillary defect (RAPD) in either eye. Intraocular pressure (IOP) was also normal in both eyes....
Purpose
To evaluate the outcomes of postoperative aqueous misdirection and factors predicting failure of interventions.
Methods
This retrospective study included 49 eyes from 47 patients with aqueous misdirection following glaucoma or cataract surgery. Resolution of aqueous misdirection (AM) was deepening of the central anterior chamber (AC) and i...
Phacomatoses are a group of neurocutaneous disorders characterized by vascular and pigmentary birthmarks, often involving multiple organ systems. Klippel–Trenaunay syndrome (KTS), a rare phacomatosis, is characterized by the classical triad of cutaneous capillary hemangiomas, venous malformations, and soft tissue overgrowth. Glaucoma secondary to a...
Precis
In eyes with Sturge-Weber syndrome with early onset glaucoma, primary combined trabeculotomy and trabeculectomy had good intermediate-term success rate and minimal postoperative complications.
Purpose
To report the intermediate-term outcomes of primary combined trabeculotomy with trabeculectomy (CTT) in early onset glaucoma with Sturge-Webe...
Purpose
To characterize hemi-retinal vein occlusion (HRVO) in patients presenting to a multi-tier ophthalmology hospital network.
Methods
This retrospective, hospital-based study analyzed 2,834,616 new patients between August 2010 and June 2021. Patients with a clinical diagnosis of HRVO in at least one eye were included as cases. Data were collec...
Purpose
To describe the clinical profile, demographics, and management of Posner–Schlossman syndrome (PSS) in patients presenting to a multitier ophthalmology hospital network in India.
Methods
This cross-sectional hospital-based study included 3,082,727 new patients presenting between August 2010 and December 2021. Patients with a clinical diagno...
We generated Optical Coherence Tomography (OCT) data of much higher resolution than usual on retinal nerve fiber layer (RNFL) thickness of a given eye. These consist of measurements made at hundreds of angular-points defined on a circular coordinate system. Traditional analysis of OCT RNFL data does not utilize insightful characteristics such as it...
Purpose
To describe the clinical profile and relative prevalence of subtypes of glaucoma presenting to a tertiary care center in India.
Methods
This cross-sectional hospital-based study included 6,120 new patients (>16 years) presenting between January 2016 and December 2017. The data were collected using an electronic medical record system.
Resu...
Purpose
To describe the demographics and clinical profile of pseudoexfoliation syndrome (PXF or PES) in patients presenting to a multi-tier ophthalmology hospital network in India.
Methods
This cross-sectional hospital-based study included 3,082,727 new patients presenting between August 2010 and December 2021. Patients with a clinical diagnosis o...
Unlabelled:
1.
Objective or purpose:
To report the profile of newly diagnosed childhood glaucoma using the Childhood Glaucoma Research Network (CGRN) classification, presenting over one year from across centers in India 2.
Design:
Prospective observational multicentric Study 3.
Subjects, participants, or controls:
Newly diagnosed children ag...
Purpose:
To evaluate the outcomes of lensectomy with a glued intraocular lens (IOL) in spherophakic eyes with secondary glaucoma and assess factors associated with failure.
Methods:
We prospectively evaluated outcomes of lensectomy with glued IOL in 19 eyes with spherophakia and secondary glaucoma (intraocular pressure (IOP) ≥22 mm Hg and/or gla...
Objectives
The purpose of this study was to describe the demographics and clinical profile of pigment dispersion syndrome (PDS) in patients presenting to a multi-tier ophthalmology hospital network in India.
Material and Methods
This cross-sectional hospital-based study included 2,961,706 new patients presenting between August 2010 and September 2...
A 69-year-old male patient with Pseudoexfoliation and open angle glaucoma presented with malignant glaucoma 1 week after undergoing gonioscopy-assisted transluminal trabeculotomy (GATT). This is a rare sight-threatening complication following gonioscopy-assisted transluminal trabeculotomy . A high index of suspicion, early detection, and prompt ins...
Introduction and importance:
The case report highlights the challenges in managing recurrent Mooren's ulcer, a rare and severe form of peripheral ulcerative keratitis.
Case presentation:
A 49-year-old male, with bilateral Mooren's disease who underwent multiple surgical interventions for visual rehabilitation but developed disease recurrence in...
Background
X-linked retinoschisis (XLRS) is a rare inherited bilateral retinal degeneration caused by mutations in RS1 gene, occurring exclusively in men. Various ocular complications associated with XLRS are reported, and angle closure glaucoma in these eyes is one such complication that is refractory and needs surgery for intraocular pressure con...
Purpose- To analyze the intraoperative challenges of cataract surgery in children, following glaucoma filtering surgery.
Methods- This was a retrospective study to analyze intra-op challenges and outcomes of pediatric cataract surgery in post-glaucoma filtration surgery eyes, between January 2007 to December 2019.
Results- We included 20 eyes of 16...
We report the case of a 60-year-old female with primary angle-closure glaucoma, who presented with intraocular pressure (IOP) of 0 mmHg, significant cataract, and finger-counting vision in her left eye (LE) following high-intensity focused ultrasound (HIFU) treatment. She underwent LE cataract surgery combined with pars plana vitrectomy, membrane p...
Background:
This report describes a very rare case of progeroid syndrome of De Barsy (Cutis laxa-corneal clouding syndrome).
Materials and methods:
A 2 year-old child presented to the pediatric ophthalmology outpatients with bilateral congenital corneal opacification along with dysmorphic facial features, including loose wrinkled skin, progeroid...
Purpose:
To describe the clinical features and treatment outcomes in spontaneous uveal effusion syndrome (UES).
Methods:
A 10-year retrospective chart review of UES patients from a tertiary eye center was carried out. Optical coherence tomography (OCT), fundus fluorescein angiography, and ultrasound biomicroscopy (UBM) scans were performed. UES...
Purpose: Our study aimed to evaluate the utility of the anterior segment morphometry for objectively assessing anterior segment architectural changes of corneal clouding in the mucopolysaccharidoses (MPS) cohort and to investigate whether these measurements correlate with the slit-lamp findings on the cornea and early diagnosis of glaucoma.
Method...
Using the OCT platform, we can generate high-resolution data on retinal nerve fiber layer (RNFL) thickness in a given eye at a large number of angular-points defined on a circular coordinate system. However, insightful characteristics of OCT RNFL data such as its circularity and granularity generally remain unutilized in its common downstream stati...
Purpose
The aim of this study was to assess the efficacy of Ahmed glaucoma valve (AGV) in eyes with Descemet’s stripping endothelial keratoplasty (DSEK) and glaucoma and evaluate the risk factors for failure.
Methods
Retrospective interventional study included 27 eyes (27 subjects) that underwent AGV implantation following DSEK. The main outcome m...
Introduction and importance
This case demonstrates an unusual presentation of HSV ocular infection and the challenges faced during the management of its complications.
Presentation of the case
A middle-aged lady, a steroid responder with Herpes Simplex virus (HSV) keratouveitis, was referred for non-response to treatment with the prophylactic dose...
Purpose:
Assessment of ocular surface in patients using anti-glaucoma medications (AGM) is rarely a priority for clinicians since glaucoma management targets intraocular pressure and preserves vision. This review summarizes the various adverse effects of topical AGM on the ocular surface and highlights the importance of ocular surface assessment i...
Purpose: To describe the demographics and clinical profile of pigment dispersion syndrome (PDS) in patients presenting to a multi-tier ophthalmology hospital network in India.
Methods: This cross-sectional hospital-based study included 2,961,706 new patients presenting between August 2010 and September 2021. Patients with a clinical diagnosis of PD...
To describe the demographics and clinical profile of patients with glaucoma presenting during the novel coronavirus (COVID-19) lockdown and unlock phases in India. This retrospective hospital-based comparative study included patients presenting between March 25, 2017, and March 31, 2021. All patients who presented with glaucoma disorders were inclu...
Purpose:
We conducted a systematic search of literature to understand the various methods of imaging of the ciliary body.
Methods:
PubMed, Science Direct, Cochrane Library and Google Scholar were searched comprehensively and systematically to find studies related to the various modalities of ciliary body imaging.
Results:
The various ciliary b...
Purpose
To assess the clinical characteristics of comorbid retinal dystrophies and primary angle closure disease.
Design
Retrospective study from January 1992 to June 2020.
Methods
This descriptive study included 92 eyes of 46 patients with comorbid retinal dystrophies and primary angle closure disease (PACD) that included eyes with primary angle...
Purpose: The purpose of this study was to evaluate glaucoma and its management in eyes with Boston type 1 keratoprosthesis (Boston-Kpro) and Aurolab keratoprosthesis (Auro-Kpro) in an Indian cohort.
Methods: This retrospective comparative case series included 175 eyes of 175 patients who underwent type 1 keratoprosthesis from 2009 until 2017; type...
Purpose:
To evaluate Vitamin B12 levels in healthcare professionals at a tertiary eyecare centre in India.
Methods:
This was a cross-sectional study conducted among healthcare professionals working at a tertiary eyecare centre in India. The sample included 2,374 employees. Chemiluminescent immunoassay method (reference range, 211-911 pg/ml) was...
Purpose:
To describe the clinical spectrum and management of glaucoma in congenital aphakia.
Methods:
The demographics and clinical spectrum of eyes with congenital aphakia with and without glaucoma were compared, and management outcomes of congenital aphakia cases with glaucoma were studied retrospectively between April 2000 and June 2020.
Res...
Purpose:
To report outcomes and assess the risk factors for failure of trabeculectomy (trab), trabeculectomy with mitomycin-C (trabMMC), and combined trabeculectomy with cataract extraction (CT) in vernal keratoconjunctivitis (VKC) eyes with steroid-induced glaucoma (SIG).
Methods:
Trab was performed in 45 eyes of 30 subjects, trabMMC in 36 eyes...
Purpose:
To evaluate the outcomes of trabeculectomy, graft survival, and risk factors for failure in post penetrating keratoplasty (PK) and Descemet's stripping endothelial keratoplasty (DSEK) eyes.
Methods:
We reviewed charts of eyes that underwent trabeculectomy for post keratoplasty glaucoma PK [25 eyes] and DSEK [14 eyes] between 1993 and 20...
Drug induced cicatrizing conjunctivitis (DICC) is defined as a disease in which conjunctival cicatrization develops as a response to the chronic use of inciting topical and, rarely, systemic medications. DICC accounts for up to one third of cases of pseudopemphigoid, a large group of cicatrizing conjunctival diseases sharing similar clinical featur...
Purpose:
To report the outcomes of trabeculectomy in eyes with refractory acute primary angle-closure attack.
Methods:
Patients with acute primary angle-closure attack and who underwent trabeculectomy for medically uncontrolled intraocular pressure within 2 months of presentation were retrospectively analyzed. Primary outcome was intraocular pre...
Aim
To evaluate the occurrence of co-existing congenital nasolacrimal duct obstruction (CNLDO) and other lacrimal anomalies in eyes with congenital glaucoma (CG).
Methods
Retrospective analysis of children aged ≤1-year with co-existing CG and CNLDO seen between 1998 and 2019, treatment interventions and outcomes.
Results
During the study period,...
PurposeTo compare the outcomes of phacoemulsification with phacotrabeculectomy in primary angle closure glaucoma (PACG) eyes with medically controlled intraocular pressure (IOP).Methods
Prospective, randomized control trial including 33 eyes of 33 patients who underwent phacoemulsification (Phaco) and 37 eyes (37 patients) who underwent phacotrabec...
Progressive optic neuropathies such as glaucoma are major causes of blindness globally. Multiple sources of subjectivity and analytical challenges are often encountered by clinicians in the process of early diagnosis and clinical management of these diseases. In glaucoma, the structural damage is often characterized by neuroretinal rim (NRR) thinni...
Purpose: To assess the clinical characteristics of comorbid retinal dystrophies and primary angle closure disease.
Design: Retrospective study from January 1992 to June 2020.
Methods: This descriptive study included 92 eyes of 46 patients with comorbid retinal dystrophies and primary angle closure disease (PACD) that included eyes with primary angl...
Purpose:
To evaluate the outcomes of trabeculectomy in the eyes with neovascular glaucoma (NVG), caused by proliferative diabetic retinopathy (PDR), central retinal vein occlusion (CRVO), and ocular ischemic syndrome (OIS).
Methods:
A retrospective review of NVG eyes that underwent trabeculectomy between 1991 and 2019. Complete success was defin...
Purpose:
The aim of this study was to report our initial experience on the outcomes of phacoemulsification in combination with goniotomy using the Kahook Dual Blade (KDB) in eyes with advanced open-angle glaucoma (OAG).
Methods:
The outcomes of phaco-goniotomy with KDB in advanced OAG in Indian eyes were retrospectively analyzed. Based on the Ho...
We report a case of conjunctival erosion due to ligature suture knot exposure following Aurolab aqueous drainage device (AADI) implantation. A 48-year-old man, a known case of primary angle-closure glaucoma, had failed trabeculectomy with mitomycin-C and Ahmed glaucoma valve (AGV) in the right eye. The right eye had a large posterior AGV bleb with...
Background
Topiramate (TPM) is a drug commonly used by neurophysicians and psychiatrists for a plethora of indications. Topiramate has been reported to induce acute angle closure glaucoma as an adverse effect. However, there is limited literature on Topiramate causing hypopyon uveitis and intense ocular inflammation. It is imperative for ophthalmol...
Purpose
This study aimed to assess the efficacy and safety of Ahmed glaucoma valve (AGV) implantation in eyes with pediatric keratoplasty and glaucoma.
Design
Retrospective, non-comparative, interventional case series.
Participants
Twenty-eight eyes of 25 children that underwent AGV following penetrating keratoplasty (PK) in 22 eyes and Descemet’...
PurposeTo compare the disease characteristics and treatment outcomes of patients with neovascular glaucoma (NVG) presenting with visual acuity (VA) 6/60 or better in two different health systems.Methods
Retrospective chart review of consecutive patients with NVG who presented between January 2016 to January 2018 in 5 tertiary-centres in India and o...
Purpose:
The aim of this study was to measure changes in intraocular pressures (IOPs) associated with inhalational and mixed anesthetic agents currently used for general anesthesia (GA) in ophthalmic surgery.
Methods:
In a cross-sectional study, 48 eyes from 48 consecutive subjects that underwent ophthalmic surgery under GA were included. Mixed...
Purpose
: To evaluate the outcomes of primary trabeculectomy with mitomycin-C (trab MMC) in phakic eyes with post-traumatic angle recession glaucoma with no prior intraocular surgeries.
Methods
: We included 32 phakic eyes of 32 patients who underwent trab MMC between January-2002 and December-2017. Complete success was IOP between 6 and 21 mm Hg...
Purpose
To study the agreement between the Icare ic200 (ICare Finland Oy, Helsinki, Finland) and the Goldmann Applanation Tonometer (GAT) in the measurement of intraocular pressure (IOP) in adult eyes.
Design
Noninterventional, cross-sectional study.
Participants
A total of 156 eyes of 156 adult participants with clear corneas were included.
Met...
Purpose:
To evaluate the long-term outcomes of Descemet-stripping endothelial keratoplasty (DSEK) in 52 eyes with iridocorneal endothelial (ICE) syndrome.
Methods:
Retrospective study of 52 eyes of 52 patients who were diagnosed with ICE syndrome and underwent DSEK between January 2010 and December 2019 with a follow-up of at least 6 months....
Background: Glaucoma is characterized by chronic progressive optic neuropathy with corresponding visual field changes, with or without raised intraocular pressure (IOP). When diagnosing glaucoma or monitoring its progression, the examiner has to rely on the appearance of the optic disc, characteristic retinal nerve fiber layer defects, and correspo...
Neovascular glaucoma (NVG) is a sight-threatening secondary glaucoma characterized by appearance of new vessels over the iris and proliferation of fibrovascular tissue in the anterior chamber angle. Retinal ischemia is the common driving factor and common causes are central retinal vein occlusion, proliferative diabetic retinopathy, and ocular isch...
Progressive optic neuropathies such as glaucoma are major causes of blindness globally. Multiple sources of subjectivity and analytical challenges are often encountered by the clinicians in the process of early diagnosis and clinical management of these diseases. In glaucoma, the structural damage is often characterized by neuroretinal rim (NRR) th...
A 61-year-old male patient presented with decreased vision and recurrent redness in his right eye since the past 4 years. He had been diagnosed elsewhere as HLA-B27 positive anterior uveitis and was on oral methotrexate and topical corticosteroids for recurrent disease. He was on maximal medical therapy for glaucoma. Examination showed prominent in...
To report the outcomes of endothelial keratoplasty (EK) combined with near total iridectomy in the management of iridocorneal endothelial (ICE) syndrome with severely disorganised anterior segment. Three patients with ICE syndrome, who had a severely disorganised anterior segment underwent near total iridectomy, with/without cataract surgery, follo...
Lack of clear guidelines and understanding makes management of glaucoma during pregnancy a major challenge. The treatment should be balanced in such a way that it is safe for the mother and the growing fetus while maintaining the intraocular pressure control and stability of glaucoma.
Prcis:
Saccadic eye movements were compared between high tension, normal tension, and primary angle closure glaucoma. Saccades were differently affected between subtypes of primary glaucoma.
Aim:
To compare saccadic eye movements in eyes with high tension primary open angle glaucoma (HTG), primary angle closure glaucoma (PACG) and normal tension...
Purpose
To validate estimation of Goldmann applanation tonometer (GAT) intraocular pressure (IOP) from scleral Schiotz IOP measurements using a regression model in normal eyes and eyes with type-1 keratoprostheses.
Methods
In this prospective cross-sectional study, cohort-1 had 253 normal anterior segment eyes, and cohort-2 had 100 eyes with type-...
Purpose
To study the effects of age, gender, intraocular pressure, corneal thickness, axial length, disc area and the signal strength of the scan on optical coherence tomography (OCT) parameters of normal subjects in L V Prasad Eye Institute-Glaucoma Epidemiological and Molecular Genetic Study (LVPEI-GLEAMS), a population-based study.
Design
Cross...
Background
Traboulsi syndrome is a rare autosomal recessive genetic disorder. The present study aimed to identify the pathogenic variants in the ASPH gene responsible for a rare and unique presentation of Traboulsi syndrome associated with cardiac disorder.
Methodology
DNA was isolated from the blood samples from 3 clinically diagnosed Traboulsi s...
Precis':
With a newly designed blade, slicing of the Ahmed glaucoma valve leaflets helped to convert the flow restrictive AGV into a non-flow restrictive device. Flow characteristics by our invitro study confirmed the loss of resistance of AGV valve leaflets.
Purpose:
To describe a new blade to destroy the valve leaflets of Ahmed glaucoma valve...
Purpose
To report clinical features and treatment outcomes of primary combined trabeculotomy with trabeculectomy (CTT) in congenital aniridia with glaucoma in children aged 3 years or less.
Design
Retrospective study
Participants
Sixty-six eyes (35 children) with congenital aniridia and early onset glaucoma who underwent CTT between May-1997 and...
Purpose
To report the clinical presentation and management outcomes of glaucoma in the “Indian Twin cities retinopathy of prematurity (ROP) Screening database.”
Methods
All children with diagnosis of ROP and glaucoma between 1997 and 2016 from a prospective database were included. Glaucoma was classified as open when anterior chamber (AC) was de...
Purpose
To study the agreement between Icare ic 200 and the Goldmann Applanation tonometer (GAT) in the measurement of intraocular pressure (IOP) in adult eyes
Design
Non-interventional, Cross-sectional study
Subjects
156 eyes of 156 adult participants with clear corneas were included.
Method
The IOP measurements were obtained with Icare ic200 (...
Precis:
Preoperative intravenous dexmedetomidine produced a 33% reduction in intraocular pressure within 15 minutes of administration in glaucoma patients.
Purpose:
To evaluate the effect of preoperative intravenous (IV) Dexmedetomidine on intraocular pressure (IOP) in adult patients undergoing glaucoma surgery under local anesthesia.
Methods:...
PurposeTo discuss the clinical presentation and management of intraocular tumors masquerading as primary glaucoma or non-tumor-related secondary glaucoma.Methods
Retrospective chart review.ResultsTen patients with unsuspected intraocular tumor were referred to glaucoma clinic with a diagnosis of primary glaucoma or non-tumor-related secondary glauc...
Purpose
To analyse the outcomes of keratoprosthesis in eyes with limbal stem cell deficiency (LSCD) and to compare the outcomes in two different keratoprosthesis devices.
Methods
This was a single-centre retrospective comparative case series which included 81 eyes of patients with severe bilateral corneal blindness secondary to LSCD. The patients...
PURPOSE:To analyse the disease burden of pseudoexfoliation (PXF) disease stages from East and South India. DESIGN:Prospective hospital based study of patients seen at 4 tertiary centres. SUBJECTS, PARTICIPANTS, AND/OR CONTROLS:Consecutive old and new patients of pseudoexfoliation with normal intraocular pressure (IOP), raised IOP (PXF with Ocular h...
Purpose:
The authors report a rare complication of "pseudophakic reverse pupillary block" after a secondary, scleral-fixated intraocular lens implantation using the Yamane technique.
Methods/results:
A 52-year-old male patient was referred for uncontrolled intraocular pressure (IOP) despite 3 topical antiglaucoma medications in his right eye (RE...
A 5-year-old boy with failed combined trabeculotomy and trabeculectomy underwent Ahmed glaucoma valve (AGV) implantation and presented 5 weeks postoperatively, with sudden onset proptosis downward displacement of the globe, limited extraocular movements and displacement of tube from anterior chamber. CT scan of the orbits showed a large cystic bleb...
Purpose:
To objectively evaluate surgically induced astigmatism (SIA) after phacotrabeculectomy using keratometry and topography and to compare the magnitude of SIA and the refractive outcomes of single-site and twin-site phacotrabeculectomies.
Methods:
Forty prospective subjects were enrolled in the study and were randomized into single-site an...
Aim:
To evaluate the success of Ahmed Glaucoma Valve Implantation (AGV) in patients with glaucoma secondary to Iridocorneal Endothelial (ICE) syndrome.
Methods:
This retrospective study included 18 eyes of 18 patients with ICE syndrome and glaucoma who had undergone AGV implantation at our institute between January 2008 and April 2019. The prima...
Glaucoma is a leading cause of blindness affecting up to 70 million people worldwide. High intraocular pressure (IOP) is a major risk factor for glaucoma. Inefficient aqueous humor (AqH) outflow resulting from structural or functional alterations in ocular drainage tissues are well established to cause high IOP, but the genes and pathways involved...
Glaucoma management during pregnancy is a challenge for the patient and doctor. During pregnancy, the intraocular pressure (IOP) decreases. However, some women with preexisting glaucoma have elevated IOP requiring enhanced medical treatment. Glaucoma refractory to medical treatment combined with disease progression may necessitate laser trabeculopl...
A one-eyed 67-year-old man with 20/400 vision, dense cataract, previously failed trabeculectomy and medically uncontrolled advanced glaucoma underwent a single-site phacoemulsification with repeat trabeculectomy and mitomycin C. One-week postoperatively, vision in the right eye improved to 20/120, good bleb and intraocular pressure (IOP) of 14 mm H...
Objectives:
To assess the ability of teleophthalmoscopic grading of peripheral anterior chamber depth (PACD) using the van Herick (vH) technique in detecting gonioscopically occludable angle; and to determine whether combining results from vH grading and ocular biometry can improve the accuracy to diagnose gonioscopically occludable angle METHODS:...
To compare the safety and efficacy of the FP8 AGV (paediatric) with the standard FP7 AGV in adult post-vitreoretinal (VR) surgery glaucoma.
We included 45 consecutive eyes with post-VR surgery glaucoma implanted with either FP8 (n = 28) or FP7 (n = 17) AGV between 2008 and 2016. The data analysed included visual acuity (VA), intraocular pressure (I...
Objective
To elucidate the difference between choroidal thickness (CT) in primary open-angle glaucoma (POAG) and normal subjects and to compare the CT measured using spectral domain optical coherence tomography (SD-OCT) and swept source optical coherence tomography (SS-OCT).
Methods and analysis
This cross-sectional observational study included 25...
Citations
... The higher IOP values and longer the pressure persists, the existing deficits deepen and spread to additional sectors. It is known that for initial change in visual field, one third of nerve fibres have to be damaged, so we should keep in mind that any sectoral thinning and its extension to the neighbouring sector in two consecutive OCT imaging measurements can be a sign that the damage has progressed [32]. From a clinical point of view, the most important question is when to start treatment of elevated IOP in GO. ...
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... Glaucoma ranks as the third leading cause of blindness in India, following cataracts and refractive errors. India faces a significant challenge with 11.9 million individuals affected by glaucoma and 8.9 million experiencing blindness [6,7] . Topical medical therapy is the most common initial treatment for glaucoma. ...
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... Доля ПВГ у пациентов с глаукомой детского возраста составляет, по данным разных авторов, 28,3 % [15], 34,4 % [16; 17], 38,9 % [18]. Большинство случаев имеет дебют в течение первых 2-х лет жизни (19 %), в неонатальном периоде выявлено 6,2 % всех случаев [16]. Преобладает двустороннее поражение (от 79 до 84 % случаев), число заболевших среди мальчиков и девочек примерно одинаково [19]. ...
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... Распространенность СПД по нашим данным составила 0,94 %, что значительно ниже данных J. Doan и соавт. [11] и выше, чем в исследовании Gazella Bruce Warjri [15]. Мы согласны с мнением авторов, что значительный разброс показателей распространенности синдрома пигментной дисперсии можно объяснить, с одной стороны, разной распространенностью его у различных наций, с другой -включением в исследование только близоруких пациентов [15,16]. ...
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... Likewise, mitochondrial dysfunction is frequently observed. It is a key characteristic of Fontaine progeroid syndrome [82][83][84][85][86] and some progeroid cutis laxa syndromes, but also contributes to the pathogenesis of several other progeroid disorders such as HGPS, mandibuloacral dysplasia type B, Cockayne syndrome [45][46][47][48][49][50], ataxia-telangiectasia, and xeroderma pigmentosum. ...
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... The sclera is thought to be quantitatively and qualitatively different in these patients. An irregular distribution of collagen fibres in each of the three layers of the sclera and increased scleral thickness has been described as a common feature of nanophthalmos, 52 and proteoglycan deposits may be found between the scleral collagen fibres. 53 Immunohistochemical analysis has shown that nanophthalmic scleral tissue has a higher presence of fibronectin and more disorder in the stromal nucleus of fibroblasts. ...
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... Topical medications: Including glaucoma drops or preservative toxicity from eye drops containing preservatives[17][18] • Skin diseases: On or around the eyelids, such as rosacea or eczema[19] • Meibomian gland dysfunction: A common comorbidity with thickening and erythema of the eyelids and inadequate or altered secretions of meibomian Chemical or thermal burns: Those that scar the conjunctiva[22] • Ocular allergies[23] • Decreased androgen levels: Ocuuring with menopause and other conditions[24] • Computer or device usage: This may lead to decreased blinking when looking at the screen.[25] • Excess or insufficient dosages of vitamins: Particularly vitamin A deficiency; can lead to xerophthalmia and the appearance of Bitot spots on the conjunctiva in severe cases[26] • Decreased sensation in the cornea: Due to: Environmental factors: Including exposure to irritants such as: ...
Reference: Dry Eye Syndrome
... The ciliary process contains 2 apical epithelial layers surrounding a capillary and interstitial tissue-filled core. [3] The deepest layer comprises nonpigmented ciliary epithelial cells joined by tight junctions and desmosomes. Pigmented ciliary epithelial cells are found in the outer layer and are joined by gap junctions. ...
Reference: Intraocular Pressure
... we found that a minority of patients with RP (0.1-8.7%) had vitreous abnormalities, such as vitreous opacities, floaters, membranes, or vitreoschisis, and degenerative changes [5,9]. To the best of our knowledge, there have been only isolated case reports explaining the role of vitrectomy in RP patients with visually significant vitreous opacities [10]. ...
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... This shortage can lead to damage to the blood and nerve systems, hinder cognitive development in infants and children, and heighten fertility risks in pregnant women [3]. The instability of hydroxycobalamin, mecobalamin, and adenosylcobalamin in cobalamin necessitates the use of synthetic cyanocobalamin in milk powder [4,5]. Cyanocobalamin, a compound with a molecular weight of 1355.4, ...
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