Shujun Li's research while affiliated with Wuhan University and other places

... These findings suggest that the role of the key genes in the cellular microenvironment might be associated with CD8 + T cells, resting NK cells, and M1 macrophages. In a previous study, snoRNAs were shown to remodel the cellular microenvironment by modulating the GAB2/AKT/mTOR signaling pathway, blocking immune checkpoints, and reducing cardiac infiltration with CD8 + T cells (44); and this finding is consistent with the low expression of SNORA80E and the infiltration with CD8 + T cells identified in the present study. Taking these results together, we can speculate that the product of the cuproptosis-related gene SNORA80E alters the immune microenvironment of cardiomyocytes via the mTORrelated signaling pathway and that CD8 + T cells are the predominant infiltrating cell type, contributing to the onset and progression of diabetic heart failure. ...

... Furthermore, NEAT1 orchestrates resistance to paclitaxel in NSCLC by activating the Akt/mTOR signaling pathway (Li et al., , 2018a. Remarkably, NEAT1 functions as a competing endogenous RNA (ceRNA) for miR-377-3p, counteracting its processes and consequently releasing the repression of endogenous targets, most notably E2F3, a central oncogene implicated in NSCLC progression (Fu et al., 2022;Sun et al., 2016;Zhang et al., 2017). NEAT1's intricate roles in promoting NSCLC progression collectively underscore its oncogenic character and offer valuable insights into the mechanisms underpinning its contributions to this disease. ...

... Although these methods offer high sensitivity, they are often associated with high costs and time-consuming procedures. [11]. Biosensors have emerged as promising diagnostic tools for early detection of lung cancer owing to their ability to provide rapid, sensitive, specific, non-invasive, and cost-effective means of detecting biomarkers associated with the disease. ...

... Overexpression of miR-187 inhibited the expression of BCL6 and knockdown of miR-187 enhanced the expression of BCL6 in HTR8 cells (Fig. 6D, E,6F). Previous studies [21,22] have used luciferase reporter gene assays in human diffuse large B-cell lymphoma cell line SUDHL2, lung cancer cell line A549 and SPC-A-1 cells respectively, and they showed that miR-187 mimics significantly inhibited wild-type-BCL6 luciferase activity, while Mut-BCL6 luciferase activity was not regulated by miR-187 ...

... miRNAs play a significant role in the progression of NSCLC, where dysregulated miRNAs function as either an oncomiRNA or anti-tumor miRNA (Feng et al. 2018), like miR-99b-5p was reported to be downregulated in NSCLC, while reduced cancer cell growth and mobility was reported with overexpressing miR-99b-5p by targeting FZD8 (Liu et al. 2019). Similarly, hindered NSCLC cellular aggressive behavior was observed with MiR-147, which exerted its role by inhibiting BDNF expression , while miR-326 was found to exert protective effects in endometrial (Cai et al. 2021) and gastric cancers (Song et al. 2020), and in NSCLC (Sun et al. 2016), and could partially reduce the resistance of A549 cells to cisplatin/cis-diamminedichloridoplatinum. Previous studies demonstrated that miR-326 was sponged by circRPPH1 in HCC (He et al. , 2020b, in addition to inhibiting papillary thyroid carcinoma via MAPK1 and ERBB4 downregulation (Nie et al. 2020). ...

... A study reported that the antifibrotic activity of SFN in attenuating the progression of hepatic fibrosis is through NRF2-mediated inhibition of the TGFβ signaling pathway, leading to reduced expression of type 1 collagen [19]. Another histopathological study reported that SFN decreases dystrophic muscle fibrosis in mdx mice via NRF2 mediation of TGFβ signaling, thereby reducing collagen deposition [35]. The above results prove that SFN could significantly alleviate oral fibrosis by inducing autophagy through the PI3/AKT/mTOR pathway via NRF2. ...

... The subsequent analysis also showed that hsa-miR-139-5p was lowly expressed in the tumor samples, and lower expression of hsa-miR-139-5p was associated with a poor prognosis of LIHC. During the past decade, several studies have investigated the role of hsa-miR-139-5p in cancers, including ovarian cancer, thyroid cancer, lung cancer, and LIHC [29][30][31]. Tu et al. found that nuclear enriched abundant transcript 1 (NEAT1) can upregulate TGF-β1 to induce hepatocellular carcinoma progression by sponging hsa-mir-139-5p [32]. The above experimental findings are consistent with our results. ...

... Discussion miRNAs (miR-206s) are a series of endogenous non-coding RNAs that inhibit the expression of proteincoding genes at transcriptional and post-transcriptional levels by binding to the 3'-untranslated region (3'-UTR) of speci c target mRNA molecules, leading to their degradation or translation inhibition. miR-206 has been found to play a crucial role in a variety of malignancies, such as lung, gastric, colorectal, and kidney cancers, and endometrioid adenocarcinoma, glioma, and neuroblastoma [17][18][19][20][21] . Sun et al. [22] demonstrated that miR-206 could bind directly to the 3'-UTR of c-Met and Bcl-2, thus affecting the proliferation, migration, and colony formation of lung cancer cells. ...

... Other anti-inflammatory effects of sulforaphane in mice have been based on ultraviolet B (UVB)-induced skin inflammation [225,226], the genetic model of muscular dystrophy [227,228], ischemia/reperfusion-induced muscular injury [229], ischaemia/reperfusion injury and cardiac allograft vasculopathy [127], vascular remodelling in hypoxic pulmonary hypertension [230], aged mice [231], angiotensin II-induced renal inflammation and injury [232], ischaemia/reperfusion injury [233], hypoxia-induced cardiomyopathy [234], the genetic model of kidney disease [235], retinitis Pigmentosa [236], atopic dermatitis [237], UV radiation-induced inflammation [238], acute exhaustive exercise-induced organ damage and inflammation [239], radiation-induced skin damage [240], oxazoloneinduced chronic itch model [241], and acute pancreatitis in mouse [158] experimental models. ...