Shuhan Cai's research while affiliated with Wuhan University and other places
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Publications (8)
Background:
Diaphragmatic ultrasound has been increasingly used to evaluate diaphragm function. However, current diaphragmatic ultrasound parameters provide indirect estimates of diaphragmatic contractile function, and the predictive value is controversial. Two-dimensional (2D) speckle tracking is an effective technology for measuring tissue defor...
Background:
The purpose of this study was to determine the feasibility, reliability, and reproducibility of parasternal intercostal muscle longitudinal strain (LSim) quantification by speckle tracking, and the value of maximal LSim to predict weaning outcomes.
Methods:
This study was divided into three phases. Phases one and two comprehended pro...
Background:
Low-flow extracorporeal carbon dioxide removal (LF-ECCO2R) has the potential to play an important role in the management of adults with acute respiratory failure. However, it has never been tested in China. The study aimed at exploring the safety and efficacy on LF-ECCO2R for acute respiratory failure in a Chinese tertiary intensive ca...
Background
The coronavirus disease 2019 (COVID-19) is an ongoing pandemic since December 2019. Invasive mechanical ventilation (IMV) is essential for the management of COVID-19 with acute respiratory distress syndrome (ARDS). We aimed to assess the impact of compliance with a respiratory decision support system on the outcomes of patients with COVI...
Background
Burnout has gained increasing attention worldwide; however, there is a lack of relevant research in China. This study investigated the prevalence and factors associated with burnout in physicians of the intensive care unit (ICU) in mainland China.
Methods
This cross-sectional multicenter study included critical care physicians from all...
Purpose:
We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pectin (P-MCP) on renal ischemia/reperfusion (I/R) induced AKI.
Methods:
Among fifty-two post-cardiac surgery patients, serum and urine Gal-3 levels were examined on intensive care unit (ICU...
Purpose:
We used lung ultrasonography to identify features of COVID-19 pneumonia and to evaluate the prognostic value.
Materials and methods:
We performed lung ultrasonography on 48 COVID-19 patients in an ICU (Wuhan, China) using a 12-zone method. The associations between lung ultrasonography score, PaO2/FiO2, APACHE II, SOFA, and PaCO2 with 28...
Objectives:
Severe acute respiratory distress syndrome is complicated with coronavirus disease 2019 and extracorporeal membrane oxygenation support may be necessary in severe cases. This study is to summarize the clinical features, extracorporeal membrane oxygenation characteristics, and outcomes of patients with severe acute respiratory syndrome...
Citations
... Xu Q et al. [118] evaluated the feasibility and reproducibility of quantification of diaphragm longitudinal strain (DLS) by STUS (study A: in 25 healthy subjects and 20 mechanically ventilated patients), and aimed to determine whether the maximum DLS can be used to predict outcomes weaning (study B: multicenter retrospective, 96 patients elected for weaning, of which 56 were successfully weaned). Intra-and inter-operator reliability was good to excellent under conditions of eupnea, deep breathing and MV. ...
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... Less than 4 studies reported on accuracy to predict weaning outcomes for maximal expiratory pressure [28,32], parasternal intercostal thickening fraction [101,111], thickness of the abdominal muscles [47], electromyography of the diaphragm [112,113], phrenic nerve stimulation [114,115] and transdiaphragmatic pressure [116]. Therefore the data on these assessments were not considered in the meta-analysis in case the studies were already included in the meta-analysis for other assessments [28,32,47,101]. ...
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... Although introduced several decades ago, the sustained employment of the ALI score in acute respiratory failure, ARDS and emergent conditions such as COVID-19 attests to its worth in severity evaluation and prognostic predictions. 27,28 This continued use accentuates the utility and pertinence of the ALI score for both non-ARDS and ARDS patients with acute respiratory failure. ...
... By pharmacologically suppressing overexpressed Gal-3, MCP normalizes the components of epithelial-mesenchymal transformation (EMT) in rats, including fibronectin, α-SMA, and β-catenin [104]. Gal-3 is also a potential early biomarker for the diagnosis of AKI in acute kidney injury, and both Gal-3 inhibition and Gal-3 knockout models have been shown to reduce the release and expression of inflammatory mediators, including IL-6, IL-1β, and TNF-α [105]. ...
... In analogy to our findings, a study conducted in China reported that burnout rates among ICU physicians exceeded 80% and severe burnout exceeding 40% in this population. 27 Thus, contrasted with other specialties, the severe burnout of ICU physicians should be given sufficient attention. In addition, the prevalence of workload and work-life imbalance for ICU was the highest among all specialties, especially workload, which was at least 26% higher, up to 64.5%. ...
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... [14] Similarly, Li et al., observed LUS score to have a significant negative correlation with PaO 2 /FiO 2 and a positive correlation with APACHE II score and 28-day mortality. [15] Scoring systems have been used and revised over the last few decades. [7,16,17] A scoring system has two parts -a score (an integer number calculated by adding the individual points allotted to surrogate markers of disease severity) and a probability model (an estimated mortality percentage denoting the probability of hospital death). ...
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... 8 La hipercapnia en neumonía grave por COVID-19 está asociada a mayor necesidad de ventilación mecánica invasiva (VMI). 9 Además, refleja tromboinflamación de la microvasculatura pulmonar; 10 contribuye a complicaciones adicionales como aumento de la presión intracraneal, disminución de la contractilidad miocárdica, liberación de catecolaminas endógenas, hipertensión pulmonar y reducción del flujo sanguíneo renal. 11 Intentar corregir la hipercapnia sólo con la modificación de las variables ventilatorias, complica mantener metas de protección pulmonar y podría ser deletéreo. ...
