Shuai-Fei Ji's research while affiliated with Chinese PLA General Hospital (301 Hospital) and other places
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Publications (5)
Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological function. Accumulating evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration, promoting sc...
Background
Large skin defects severely disrupt the overall skin structure and can irreversibly damage sweat glands (SG), thus impairing the skin’s physiological function. This study aims to develop a stepwise reprogramming strategy to convert fibroblasts into SG lineages, which may provide a promising method to obtain desirable cell types for the f...
Noise pollution has become one of the important social hazards that endanger the auditory system of residents, causing noise-induced hearing loss (NIHL). Oxidative stress has a significant role in the pathogenesis of NIHL, in which the silent information regulator 1(SIRT1)/proliferator-activated receptor-gamma coactivator 1α (PGC-1α) signaling path...
Free radicals and oxidative stress play an important role in the pathogenesis of noise-induced hearing loss (NIHL). Some ginseng monomers showed certain therapeutic effects in NIHL by scavenging free radicals. Therefore, we hypothesized that ginsenoside Rd (GSRd) may exert neuroprotective effects after noise-induced auditory system damage through a...
Citations
... To skin cells, epithelial cells cultured on stiff matrixes exhibited higher activity of migration and adhesion, and the higher activity of cells can maintain for a long time after transfer on the softer matrix [155]. Matrix with too hard stiffness will lead to differentiation of fibroblasts to myofibroblasts, which is the key pathological process causing the formation of hypertrophic scars [156]. In addition, the mechanical signals were also reported to regulate immune responses by influencing the behavior of human monocyte-derived macrophages [157], which can further affect the inflammatory phase of wound healing. ...
... This trend can be attributed to the adverse effects and exorbitant costs associated with biologics, particularly in the treatment of conditions such as psoriasis and other immune diseases. Notably, ginsenoside radix has demonstrated its efficacy in preventing lung injury through its anti-inflammatory and anti-oxidative properties [34]. Re-Du-Ning injection ameliorates radiation-induced pneumonitis and fibrosis [35], as well as lung injury induced by LPS [36]. ...
... Similar to sweat gland regeneration strategies, transplanting seed cells to regenerate sweat glands and inducing endogenous sweat glands regeneration by biomaterials are the two main ideas to achieve structural and functional regeneration of sweat glands. Now various strategies such as stem cell therapy, bioactive factor induction and small molecule reprogramming have been applied to sweat gland regeneration studies [139]. ...
... As such, these features can also be useful in terms of volatility forecasting with several states or breaks. [12] showed that GRU outperforms another deep learning algorithms in forecasting CSI 300 realized volatility. Moreover, other studies showed that GRU outperforms popular GARCH models in forecasting the volatility of Bitcoin [43]. ...
