Shruti Sharma's research while affiliated with Dr. Harisingh Gour Vishwavidyalaya Sagar and other places

Strategically controlling concentrations of lipid‐conjugated L‐tryptophan (vsPA) guides the self‐assembly of nanostructures, transitioning from nanorods to fibres and culminating in spherical shapes. The resulting Peptide‐Au hybrids, exhibiting size‐controlled 1D, 2D, and 3D nanostructures, show potential in antibacterial applications. Their high biocompatibility, favourable surface area‐to‐volume ratio, and plasmonic properties contribute to their effectiveness against clinically relevant bacteria. This controlled approach not only yields diverse nanostructures but also holds promise for applications in antibacterial therapeutics.

The microbiota‐gut‐brain axis (GBA) plays a critical role in the development of neurodegenerative diseases. Dysbiosis of the intestinal microbiome causes a significant alteration in the gut microbiota of Alzheimer's disease (AD) patients, followed by neuroinflammatory processes. Thus, AD beginning in the gut is closely related to an imbalance in gut microbiota, and hence a multidomain approach to reduce this imbalance by exerting positive effects on the gut microbiota is needed. In one example, a tyrosine‐based short peptide amphiphile (sPA) was used to synthesize antibacterial AgNPs−sPA nanostructures. Such nanostructures showed high biocompatibility and low cytotoxicity, and therefore work as model drug delivery agents for addressing local bacterial infections. These may have therapeutic value for the treatment of microbiota‐triggered progression of neurodegenerative diseases.

Metallopeptide-inspired, pyridine-bis-tyrosine short peptide conjugate was developed which coordinates Hg(II) ions and hence was further used for the formation of solid mercury nanoparticles at ambient conditions. The formation of solid mercury nanoparticles was obtained from the transformation of stable mercury nanodrops which are guided by peptide nanostructures. Our results showed that initially Hg(II) ions get converted into Hg(0) nanodrops(HgNDs) and stabilized by peptide envelope which subsequently transformed into solid HgNPs with the help of time-dependent electron beam exposure under peptide nanostructure envelope. The solid HgNPs exhibit remarkable rhombohedral morphology and are found crystalline at room temperature. To the best of our knowledge, this is the first report of peptide-mediated electron beam-induced facile synthesis of solid mercury nanoparticles from less toxic Hg(II) ions at room temperature.

An effortless thermoplasmonic welding of multi-shaped gold nanosheets is achieved by ordinary and simple sunlight irradiation. A light-matter interaction occurred via nanogaps of smaller nanosheets leading to the enhancement of...