Shreya Pusapadi Ramkumar's research while affiliated with Saint Louis University and other places
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Publications (11)
272
Background: Roughly two-thirds of patients diagnosed with head and neck cancer (HNC) have advanced-stage disease and many are eligible for palliative care. However, only approximately 20% of patients actually receive palliative care after their HNC diagnosis. The factors that affect access to palliative care for these individuals are not well u...
Importance:
The US Food and Drug Administration approved immune checkpoint inhibitors (immunotherapy) for select cases of head and neck squamous cell carcinoma (HNSCC) in 2016. However, it is unclear whether there are clinical or sociodemographic differences among patients receiving immunotherapy as part of their care. Given the known disparities...
Background
Despite the increasing prevalence of breast implant associated anaplastic large cell lymphoma, there remains a paucity of literature guiding management of asymptomatic patients with textured breast implants. This risk can be anxiety provoking in breast reconstruction patients given their history of cancer or increased future risk. The pu...
KEY POINTS
There is no consensus on the extent of appropriate surgery for chronic rhinosinusitis (CRS), particularly CRS without polyps (CRSsNP).
There is wide heterogeneity in the definition of “limited” and “extensive” endoscopic sinus surgery (ESS).
Studies on the appropriate extent of surgery for CRS are needed.
Shared decision-making is an approach where physicians and patients work together to determine a personalized treatment course. Such an approach is integral to patient-centered care in chronic rhinosinusitis with nasal polyps (CRSwNP). CRSwNP is a chronic inflammatory condition of the sinonasal cavity that can severely impact physical health, smell...
Background
There has been conflicting evidence on the independent prognostic role of human papillomavirus (HPV) status in sinonasal cancer. The objective of this study was to assess whether the survival of patients with sinonasal cancer differs based on various HPV statuses, including HPV‐negative, positive for the high‐risk HPV‐16 and HPV‐18 (HPV1...
Discerning the genetics and epigenetics of chronic rhinosinusitis (CRS) may optimize outcomes through early diagnostics, personalized and novel therapeutics, and early prognostication. CRS associated with cystic fibrosis and primary ciliary dyskinesia has well-characterized genetic mutations. Most CRS subjects, however, do not exhibit identifiable...
Background:
Biological sex is increasingly recognized as a critical variable in healthcare. We reviewed the current literature regarding sex-based differences in rhinology to summarize the data and identify critical knowledge gaps.
Methods:
A scoping review was conducted. Publications reporting sex-based differences in anatomy, physiology, and p...
6565
Background: The sinonasal tract is a lesser known “hot spot” for the human papillomavirus (HPV), compared with the oropharynx. Additionally, unlike the oropharynx, the role of HPV tumor status in the survival and overall prognosis of the sinonasal tract and other non-oropharyngeal head and neck cancer sites remains inconclusive. Understanding...
Citations
... These approaches are driven by novel theories that integrate anatomical and inflammatory concepts (i.e., the mucosal concept), aimed at enhancing comprehension and management of the CRSwNP disease [18]. Although E-FESS has often been described as a complete sphenoethmoidal resection, associated with a maxillary antrostomy and a modification of the frontal sinus ostium [19][20][21], different surgical definitions, with no clear criteria by which to comprehensively define their appropriate extent, coexist in the literature, rendering an effective comparison of results among studies especially difficult [22,23]. ...
... Ongoing research is focused on identifying new biologic agents and alternative targets, underscoring the need for reliable biomarkers and expanded clinical trials, especially for specific groups such as pediatric patients [119]. For further research, it is important to address the regulatory hurdles facing pediatric clinical trials. ...
... Multiple dynein genes (DNAH5, DNAH8, DNAH9, and DNAH11) have been associated with chronic rhinosinusitis. 18 The role of dynein genes in nasal polyposis or AERD has not been established. ...
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... While such cases are rare, they represent a persistent, likely growing minority (14)(15)(16), as there is little reason to expect that surgical procedures like colectomy or thyroidectomy occur in different rates between transgender and gender diverse (TGD) patients and non-TGD patients. Among such samples, incomplete information about sex and gender identity limits the ability to adjust for sex-specific confounders, especially with subsamples where recognized sex-specific confounders exist, such as chronic rhinosinusitis (17,18), bladder cancer (19), and colon cancer. (20) While it is notable that some gender diverse people may have received interventions intended to align sex characteristics with gender identity (i.e., hormone Incomplete information about sex and gender identity also limits the ability of surgical quality registries to achieve their intended purpose of improving outcomes and ensuring safety. ...
