Shook-Fong Chin's research while affiliated with University of Texas Southwestern Medical Center and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (4)
beta-Lapachone (ARQ 501, a formulation of beta-lapachone complexed with hydroxypropyl-beta-cyclodextrin) is a novel anticancer agent with selectivity against prostate cancer cells overexpressing the NAD(P)H:quinone oxidoreductase-1 enzyme. Lack of solubility and an efficient drug delivery strategy limits this compound in clinical applications. In t...
The success of many projected applications of carbon nano-tubes (CNTs) to living cells, such as intracellular sensors and nanovectors, will depend on how many CNTs are taken up by cells. Here we report the enhanced uptake by HeLa cells of single-walled CNTs coated with a designed peptide termed nano-1. Atomic force microscopy showed that the disper...
We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micell...
Antibody-modified microwell arrays were fabricated using site-selective photobiotin chemistry and the biotin–avidin interaction. In one scheme, an aminopropyl-functionalized glass surface was the starting substrate and in the other an acid-treated glass surface was employed. In both schemes, the substrates were coated with the aryl azide photobioti...
Citations
... Most protocols require the sensing (or binding) component to be fixed to the surface of the well to facilitate removal of un-bound substrates in one or more wash steps. 3 A convenient and inexpensive method for such attachment is through the in-situ formation of hydrogels within the wells of the multi-well plate. 4,5 Such a strategy usually requires the sensor to by covalently bound within the hydrogel matrix to prevent leaching during the swelling or wash steps. ...
... β-Lapachone has been widely studied for its pharmacological effects. Studies have found that it exhibits cytotoxic potential in different types of cancer, including breast cancer [6], prostate cancer [7], multiple myeloma [8,9], hepatocellular carcinoma [10], pancreatic cancer [11,12], human leukemia [13], and others. When studying compounds with potential anticancer activity and evaluating new medicines for use in treating illness, it is important to determine whether they are safe to use. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/787435004907521-1564750543791_Q64/Erik-Bey.jpg)
... The ability of these DDS to perform many tasks is further increased by including a medicinal drug in the payload. Similar to this, MNPs have also been entrapped using multifunctional micelles produced by using amphiphilic block copolymers for these applications [83,84]. The ability of peptide-modified liposomes to deliver therapeutic and diagnostic substances to specific blood vessels has been investigated. ...
... Various methods are used to characterize CNTs, including particle size distribut zeta potential [32], scanning electron microscopy (SEM), scanning tunneling microsc (STM), X-ray photoelectron spectroscopy (XPS) [33], X-ray diffraction (XRD), transmis electron microscopy (TEM) [34,35], neutron diffraction, infrared spectroscopy (IR) [36] photoluminescence spectroscopy. These characterization techniques can be employed characterizing native as well as drug loaded CNTs. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/878873562578944-1586551194780_Q64/Alan-Dalton-2.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272439162699787-1441965966171_Q64/Gregg-Dieckmann.jpg)
