Sheng Chen's research while affiliated with Hofstra Northwell School of Medicine and other places

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Publications (1)


Figure 1. Histopathology of the right submandibular gland mass, showing nodular proliferation of uniform basaloid cells in a cribriform pattern, consistent with adenoid cystic carcinoma.  
Figure 2. Histopathology of adenoid cystic carcinoma showing perineural invasion.  
Figure 3. Right toes nodules, 12 years after the original ACC diagnosis.  
Figure 4. Histopathology of the skin biopsy, showing infiltrating nodular proliferation of uniform basaloid cells in a cribriform pattern, similar to the primary ACC (low power).  
Figure 5: Histopathology of the skin biopsy, showing infiltrating nodular proliferation of uniform basaloid cells in a cribriform pattern, similar to the primary ACC (high power).

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Adenoid cystic carcinoma of submandibular gland metastatic to great toes: case report and literature review
  • Article
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July 2016

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308 Reads

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11 Citations

Clinical Case Reports

Clinical Case Reports

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Sheng Chen

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Dennis Kraus

Key Clinical Message Adenoid cystic carcinoma (ACC) is a rare malignant tumor of the salivary glands, with higher frequency in the submandibular gland, a prolonged clinical course, and poor long‐term survival. It tends to metastasize to lungs, bone, liver, brain, and rarely to skin. Comprehensive skin examination and appropriate follow‐up is recommended, since cutaneous metastasis represents disease progression, requiring management and prognosis adjustment.

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Citations (1)


... Adenoid cystic carcinoma (ACC) accounts for 10 to 12% of all salivary gland malignant neoplasms with an estimated incidence of 3 to 4.5 cases per million per year. 1 Perineural spread and repeated local recurrences are the primary characteristics of ACC, while lung and liver are the most prevalent distant sites of metastases. 2 Remote bone metastases from ACC of the salivary gland are relatively uncommon. 3 Few reports of ACC with bone metastases have been recorded so far. ...

Reference:

Metastasis of Maxillary Sinus Adenoid Cystic Carcinoma to the Humerus Bone—A Rare Case Report
Adenoid cystic carcinoma of submandibular gland metastatic to great toes: case report and literature review
Clinical Case Reports

Clinical Case Reports