Shama V. Birla's research while affiliated with University of North Carolina at Chapel Hill and other places

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Publication (1)

Bioorthogonal Chemical Epigenetic Modifiers Enable Dose-Dependent CRISPR Targeted Gene Activation in Mammalian Cells
Article
  • Mar 2022
CRISPR-Cas9 systems have been developed to regulate gene expression by using either fusions to epigenetic regulators or, more recently, through the use of chemically mediated strategies. These approaches have armed researchers with new tools to examine the function of proteins by intricately controlling expression levels of specific genes. Here we...
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Citations

... We have previously shown that endogenous epigenetic machinery can be harnessed to control both exogeneous and endogenous gene expression in vitro by using bifunctional molecules known as chemical epigenetic modifiers (CEMs) along with DNA-binding proteins. [9][10][11] CEM compounds are made of a FK506 molecule with a polyethylene glycol (PEG) linker connecting a compound that can recruit endogenous epigenetic machinery, when coupled with a protein targeting system we can regulate the gene of interest. ...
Reference: Chemical Epigenetic Regulation of Adeno-Associated Virus Delivered Transgenes
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