Nassau University Medical Center

Security Forces Hospital - Makkah  (SFHM)

The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson's disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries. As our increased capabilities collide with the increased demands in neurology, Future Neurology (ISSN: 1479-6708) provides a forum to address most important challenges and advances, highlighting their relevance in the clinical setting. Future Neurology delivers this essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. Coverage includes: Advanced computer and software systems for modeling and directing therapy; Adverse events and drug safety; Biological processes involved in neurological dysfunction and how new understanding will impact treatment; Disease risk assessment; Clinical implications and applications for new biomarkers; Genetic contributions to neurological disorders such as epilepsy and autism; Impact of molecular genetics on prevention, screening, diagnosis and treatment; Integration of diagnostic and therapeutic approaches; Neuropsychiatric disorders and impact of pharmacogenomics and personalized therapies; New therapeutic targets; Pharmacoeconomics and cost - benefit issues in neurology; Potential applications of stem cells and gene therapy in neurodegenerative diseases; Profiles of new neurotherapeutic agents; Selective and 'personalized' approaches. Advances in neurology promise effective treatments for diseases that have long been regarded as intractable. As the literature around these therapeutic needs and advances proliferates, Future Neurology provides authoritative commentary and analysis to draw attention rapidly, clearly and concisely to the key scientific and clinical issues that confront us in a new era of healthcare.

Future Neurology

CLIPPER is a chronic inflammatory disorder in the CNS, which is characterized by MRI appearance of punctate and curvilinear gadolinium enhancement that involve the pons and the cerebellum and exquisite response to steroid. We report a patient presented with clinical and radiological features suggestive of CLIPPERS. However, despite the initial response to steroid, there were dramatic changes in the course of his disease that were conducive to considering another diagnosis. We searched PubMed using word (CLIPPERS) till December 2018. The pathogenesis, clinical manifestations, imaging features, treatment and prognosis of this disorder are summarized. A review of the literature for cases of CLIPPERS demonstrated a subset of patients who later discovered to have an alternative pathology. Indeed, clinicians should be scrupulous to diagnose this disease based solely on the clinical and radiological findings and they should have a lower threshold of having a brain biopsy.

Case Report with Review of Literature for the Dilemma of Diagnosis of CLIPPERS

Clinical characteristics, management, and outcomes of CLIPPERS: A comprehensive systematic review of 140 patients from 100 studies

Future Medicine

Our initial search retrieved 1251 articles, of which 100 (16-22) (23-26) (2,(6)(7)(8)(9)(10)(11)(12)23, were finally included in accordance with our inclusion criteria. Of the 100 articles, 12 were case series (21-23, 45,46,83,93,96,97,99,100,108) (including 52 patients) and 88 were case reports (6)(7)(8)(9)(10)(11)(12)(16)(17)(18)(19)(20)(47)(48)(49)(50)(51)(52)(53)(54)(55)81,82,(84)(85)(86)(87)(88)(89)(90)(91)(92)94,95,98,(101)(102)(103)(104)(105)(106)(109)(110)(111). Risk of bias was low for all included case reports and series (Supplementary Table 1 and 2, respectively). 

Shadi M Ramadan's research while affiliated with Security Forces Hospital - Makkah (SFHM) and other places

What is this page?

Publications (1)

Citations (1)