Seungju Song's research while affiliated with Daejeon Institute Science and Technology and other places
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Publications (2)
O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcyl...
Citations
... Although the exact roles of O-GlcNAcylation in synaptic function remain unclear, research has extensively investigated its role in aging-associated neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Elevated O-GlcNAcylation has been shown to prevent protein aggregation and slow neurodegeneration, making it a promising therapeutic target for these conditions(68).Another noteworthy modulation is the LSD-induced upregulation of copine-1 (CPNE1) in both concentrations. Studies have demonstrated that CPNE1 activates the AKT-mTOR signaling pathway in neural stem cells (NSCs) (71). ...
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