Sau Man Sandra Chan's research while affiliated with Alice Ho Miu Ling Nethersole Hospital and other places
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Publications (5)
Signatures of immune dysregulation as clinical biomarker for psychosis have remained unclear. We aimed to compare the Neutrophil-to-lymphocyte ratio (NLR) of patients with acute non-affective first-episode psychosis (FEP) with healthy controls after accounting for emotional states. We also explored the associations of NLR with symptom severity, ons...
Signatures of immune dysregulation as clinical biomarker for psychosis have remained unclear. We aimed to compare the Neutrophil-to-lymphocyte ratio (NLR) of patients with acute non-affective first-episode psychosis (FEP) with healthy controls after accounting for emotional states, and explore their associations with symptom severity, onset profile...
Purpose
The cognitive neuropsychological model of depression suggests that the cognitive deficits observed in depressed subjects are the result of attenuated top-down cognitive control resulting in increased bottom-up emotional processing. Remediation of cognitive impairments in cold cognition has been proposed as a valuable treatment for depressio...
Background:
Cognitive deficits and eye movement abnormalities have been demonstrated to be detectable early clinical manifestations of Parkinson's disease. Understanding the relationship between these phenotypes may yield insight into the underlying anatomical pathways, assisting in the search for simple non-invasive markers of early neurodegenera...
Citations
... We did not find any studies on MLR, PLR, SII, or ESR. In the limited number of studies on NLR, no relationship was found between NLR and cognitive functions in untreated psychosis patients [31]. There are many studies investigating the relationship between cognitive impairment and CRP in schizophrenia patients. ...
... A few studies used the standardized MATRICS™ Consensus Cognitive Battery (MCCB) [37,38], while others used specific tasks to evaluate domains like working memory. While most protocols have used two mA of current for a 20-min session with twice daily sessions for 5 to 14 days, the cathodal electrode placements have varied (anodal stimulation is at left DLPFC most commonly), from the right supraorbital [37][38][39][40], left TPJ [41][42][43], and right DLPFC [44]. A larger number of sessions and days could be needed to enhance cognitive abilities in the patients compared to those required for reducing AVH. ...
Reference: Role of tDCS in Schizophrenia Management
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... Responders displayed better attentional control [46,47] and sustained attention than non-responders [48]. Furthermore, clinical responders show acute neurocognitive improvements on attentional control after a rTMS single session, in the absence of mood effects, that could be interpretable as predictors of clinical outcomes [47]. ...
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... Eye movement parameters (e.g., saccade metrics) are strongly associated with cognitive performance in individuals with early-stage PD (Archibald et al., 2013;Chan et al., 2005;Munoz & Everling, 2004;Terao et al., 2013;UP et al., 2005;Wong et al., 2018). The potential mechanisms that could explain the relationship between oculomotor performance and correlated cognitive functions encompass neuroanatomical and neurochemical levels. ...
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