Sang Baek Koh's research while affiliated with Yonsei University Hospital and other places
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Publications (172)
Background
Data from mechanistic studies suggest flavonoids may benefit glucose metabolism, but their associations with type 2 diabetes (T2D) remain unclear. This study examined the prospective associations of dietary intake of total, classes, and individual flavonoids, as well as their source foods, with T2D in the CArdioVascular disease Associati...
Objectives:
Mushrooms, known for their nutritious and functional components, are considered healthy and medicinal. This study investigated the prospective association between dietary mushroom consumption and the incidence of type 2 diabetes among Korean adults aged ≥40 years.
Methods:
In total, 16,666 participants who were not taking anti-diabet...
Objectives:
Limited and inconsistent prospective evidence exists regarding the relationship of dietary total antioxidant capacity (dTAC) and antioxidant intake with metabolic syndrome (MetS) risk. We evaluated the associations of the cumulative averages of dTAC and antioxidant intake (in 5 classes: retinol, vitamin C, vitamin E, carotenoids, and f...
Background:
The UK National Health Service (NHS) has introduced a digital social prescribing (DSP) system to improve the mental health of the aging population. In Korea, an ongoing pilot social prescribing project has been implemented for older individuals in rural areas since 2019.
Objective:
This research aims to develop a DSP program and to e...
Background:
While the importance of mental health is well-recognized in the field of occupational health, implementation of effective strategies in the workplace has been limited by gaps in infrastructure, program comprehensiveness, coverage, and adherence. The authors developed a Screening, Brief Intervention, and Referral to Treatment (SBIRT) mo...
The electrocardiogram (ECG) has been known to be affected by demographic and anthropometric factors. This study aimed to develop deep learning models to predict the subject’s age, sex, ABO blood type, and body mass index (BMI) based on ECGs. This retrospective study included individuals aged 18 years or older who visited a tertiary referral center...
Background:
Social loneliness is a prevalent issue in industrialized countries that can lead to adverse health outcomes, including a 26% increased risk of premature mortality, coronary heart disease, stroke, depression, cognitive impairment, and Alzheimer's disease. The UK government has implemented a strategy called A Connected Society, which inc...
BACKGROUND
Social loneliness is a prevalent issue in industrialized countries that can lead to adverse health outcomes, including a 26% increased risk of premature mortality, coronary heart disease, stroke, depression, cognitive impairment, and Alzheimer disease. The United Kingdom has implemented a strategy to address loneliness, including social...
BACKGROUND
The UK National Health Service (NHS) has introduced a digital social prescribing (DSP) system to improve the mental health of the aging population. In Korea, an ongoing pilot social prescribing project has been implemented for older individuals in rural areas since 2019.
OBJECTIVE
This research aims to develop a DSP program and to evalu...
Importance
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis. Few studies have evaluated the mortality outcomes of patients with PG.
Objective
To investigate all-cause and cause-specific mortality in patients with PG.
Design, Setting, and Participants
This retrospective population-based cohort study used data from the National Health In...
The purpose of this study is to determine the effect of cancer survivorship stage and health-related behaviors on the risk of developing mental health problems (depressive and anxiety disorders) in women who have experienced cancers that affect women (breast cancer, cervical cancer, ovarian cancer, endometrial cancer). Using the healthcare utilizat...
Firefighters are exposed to physical and mental threats in the working environment that put them at risk for occupational stress and burnout. Stress responses can impact the functional interactions between brain regions involved in emotional and cognitive regulation. The objective of this study was to investigate brain functional connectivity (FC)...
Background
Chronic kidney disease(CKD) is a major public health issue and is highly prevalent in the general population. Leptin is an adipose tissue-derived endocrine factor that has been associated with several metabolic factors involved in cardiovascular diseases. Several studies have investigated the association between leptin and renal diseases...
We propose a method for data provision, validation, and service expansion for the spread of a lifelog-based digital healthcare platform. The platform is an operational cloud-based platform, implemented in 2020, that has launched a tool that can validate and de-identify personal information in a data acquisition system dedicated to a center. The dat...
Background
Metabolic syndrome (MetS) is caused by both genetic and environmental factors, such as daily calorie intake, smoking, and alcohol consumption. Lifestyle factors, such as alcohol consumption, are considered to be related to the prevalence of MetS and plays an essential role in the pathogenesis and prognosis of depression.
Methods
We inve...
This study aimed to develop and validate the hypertension risk prediction models of the CArdioVascular disease Association Study (CAVAS). Overall, 6,186 participants without hypertension at baseline were randomly divided into derivation and internal validation sets in a 6:4 ratio. We derived two prediction models: the first used the Framingham hype...
Whether having a tattoo increases the risk of transfusion-transmitted diseases (TTDs) is controversial. Although a few studies have suggested a strong association between having tattoos and TTDs, other studies have not shown the significance of the association. In addition, previous studies mainly focused only on hepatitis C viral infections. The o...
Purpose
We propose the Lifelog Bigdata Platform as a sustainable digital healthcare system based on individual-centric lifelog datasets and describe the standardization of lifelog and clinical data in its full-cycle management system.
Materials and Methods
The Lifelog Bigdata Platform was developed by Yonsei Wonju Health System on the cloud to sup...
Purpose: We propose the Lifelog Bigdata Platform as a sustainable digital healthcare system based on individual-centric lifelog datasets and describe the standardization of lifelog and clinical data in its full-cycle management system.
Materials and Methods: The Lifelog Bigdata Platform was developed by Yonsei Wonju Health System on the cloud to s...
Purpose:
Several artificial intelligence (AI) models for the detection and prediction of cardiovascular-related diseases, including arrhythmias, diabetes, and sleep apnea, have been reported. This systematic review and meta-analysis aimed to identify AI models developed for or applicable to wearable and mobile devices for diverse cardiovascular-re...
Background
It is known in some studies that higher the LDL-C, the greater the risk of developing cardiovascular disease. However, studies of the causal effects between LDL-C and hypertension are limited by their observational study design, and genetic epidemiology studies of associations between LDL-C and hypertension are lacking, as are studies us...
Objectives: Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent metabolic disease. Muscle is known to influence NAFLD development. Therefore, this study aimed to determine the relationships among low muscle mass, NAFLD, and hepatic fibrosis using various definitions of low muscle mass and NAFLD diagnostic methods, including magne...
Background
Alcohol, a known addictive substance, affects the structural properties of the brain. In this study, we explored associations between alcohol use and gray matter properties among firefighters, who are often exposed to significant occupational stress.
Methods
Gray matter volume (GMV) was evaluated using voxel-based morphometry in 287 mal...
Background: As a result of the unprecedented COVID-19 pandemic, the measures of reducing social interactions and physical activity to control the sever situation could make the populations suffer from anxiety, stress, and depression. The study was to identify the predictors of depressive symptoms among university students worldwide as a result of t...
Alterations in xanthine oxidase activity are known to be pathologically influential on coronary artery disease (CAD), but the association between purine-related blood metabolites and CAD has only been partially elucidated. We performed global metabolomics profiling and network analysis on blood samples from the Wonju and Pyeongchang (WP) cohort stu...
Objectives
This study aimed to evaluate the association between dietary intakes of total antioxidant capacity (TAC) and its subclasses (flavonoids and its individual subclass and individual vitamins) and incidence risk of Metabolic syndrome (MetS) in the KoGES_CArdioVascular disease Association Study (CAVAS).
Methods
A total of 11,272 participants...
Background
Intraoperative hypotension is associated with a risk of postoperative organ dysfunction. In this study, we aimed to present deep learning algorithms for real-time predictions 5, 10, and 15 min before a hypotensive event.
Methods
In this retrospective observational study, deep learning algorithms were developed and validated using biosig...
Alopecia areata (AA) is a chronic and recurrent disorder resulting in hair loss.¹,2 The extent of hair loss is the most important prognostic factor.³ Diverse assessment tools have been developed for objective evaluation⁴; however, most have limited accuracy and objectivity because of their dependency on naked-eye examination. We postulated that com...
Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD); however, more than 25% of COPD patients are non-smokers, and gene-by-smoking interactions are expected to affect COPD onset. We aimed to identify the common genetic variants interacting with pack-years of smoking on FEV1/FVC ratios in individuals with normal lung funct...
Objectives:
This study was conducted to determine the incidence and risk factors of myocardial infarction (MI) and stroke in farmers compared to the general population and to establish 5-year prediction models.
Methods:
The farmer cohort and the control cohort were generated using the customized database of the National Health Insurance Service...
Purpose of review:
Excessive dietary salt intake is associated with an increased risk of hypertension. Salt sensitivity, i.e., an elevation in blood pressure in response to high dietary salt intake, has been associated with a high risk of cardiovascular disease and mortality. We investigated whether a causal association exists between dietary sodi...
Several studies have reported that weight control is of paramount importance in reducing the risk of metabolic syndrome. Nevertheless, this well-known association does not provide any practical information on how much weight loss in a given period would reduce the risk of metabolic syndrome in individuals in a personalized setting. This study aimed...
Residential radon exposure and cigarette smoking are the two most important risk factors for lung cancer. The combined effects thereof were evaluated in a multi-center matched case-control study in South Korea. A total of 1038 participants were included, comprising 519 non-small cell lung cancer cases and 519 age- and sex- matched community-based c...
Objectives
This study investigated the risk associated with interhospital transfer of patients with acute myocardial infarction (AMI) and clinical outcomes according to the location of the patient’ residence.
Design
A nationwide longitudinal cohort.
Setting
National Health Insurance Service database of South Korea.
Participants
This study includ...
Background
Mitochondrial DNA (mtDNA) copy number and deletion ratio may be asymmetrically determined using physiologic or pathologic conditions. Mitochondrial dysfunction is associated with an increased risk of developing metabolic syndrome (MetS).Objective
Here, we investigated the association between mtDNA copy number and/or deletion ratio and th...
Background:
Hypertension is one of the risk factors for obesity-related cardiovascular diseases. We investigated whether genetic variations in serotonin 2A receptor (HTR2A) were associated with hypertension.
Methods:
We carried out a cross-sectional study in cohorts A (Ansan-Ansung cohort, N = 6039) and B (Wonju-Pyengchang cohort, N = 7524). Sev...
Firefighters have a high risk of developing cardiovascular and mental disorders due to their physical and chemical environments. However, in Korea, few studies have been conducted on environmental risk of firefighters. The Firefighter Research on the Enhancement of Safety and Health (FRESH) study aimed to discover the risk factors for cardiovascula...
Background:
The aim of this study was to determine whether there is a positive correlation between gamma-glutamyltransferase (GGT) levels and the prevalence of metabolic syndrome and whether GGT can be used as an easily checkable metabolic index using data from the large-scale Korean Genome and Epidemiology Study (KoGES).
Methods:
We obtained da...
Background: Residential radon exposure and cigarette smoking are the two most important risk factors for lung cancer. The combined effects thereof were evaluated in a multi-center matched case-control study in South Korea.
Methods: A total of 1,038 participants were included, comprising 519 non-small cell lung cancer cases and 519 age- and sex- mat...
Objective:
We investigated the association between suicide and pesticide exposure in a community-based cohort study.
Methods:
We performed a longitudinal analysis of 6333 who participated in the initial survey of the Korean Genome and Epidemiology Study. Data were collected using a questionnaire to assess the prevalence of suicide. We calculated...
Background
Titanium dioxide nanoparticles (TiO2 NPs) represent a scientific breakthrough in the areas of biological and medicinal applications. Interaction of TiO2 NPs with components of innate immune system remains elusive.
Aim
This study explored in vitro immunotoxicity of murine macrophage RAW 264.7 to TiO2 NPs (20 nm, negative charge) and its...
Background:
We investigated whether serum leptin can be a predictor for incident cases of MetS in a population-based study.
Methods:
This is a prospective cohort study of 1590 adults aged between 40 and 70 years, who did not have MetS in 2005-2008 (at baseline) and 2008-2011 (follow-up). The baseline serum leptin concentrations were measured by...
Background
Lung cancer in never smokers (LCINS) differs etiologically and clinically from lung cancer attributed to smoking. After smoking, radon exposure is the second leading cause and the primary risk factor of lung cancer among never smokers. Exposure to radon can lead to genetic and epigenetic alterations in tumor genomes affecting genes and p...
Background:
Several anthropometric indices such as body mass index (BMI) and waist circumference (WC) have been examined as indicators of cardiovascular diseases, in both adults and children. However, the waist-to-height ratio (WHtR) is considered a better predictor for the detection of cardiovascular risk factors, than BMI. We investigated the as...
Background
Adult mortality is associated with different demographic and behavioral risk factors including approaches to health care financing. Adult mortality rate significantly reflects the effectiveness of public health-related program and intervention. The aim of this study was to find strength of association between key health’s related indicat...
Purpose:
Fibroblast growth factor 21 (FGF21) is a crucial metabolic regulator, with multiple favorable effects on glucose homeostasis and lipid metabolism. Since serum FGF21 level has been implicated as a potential marker for the early identification of metabolic syndrome (MetS), we investigated the association between serum FGF21 level and the de...
The purpose of this study was to examine the relationship between emotional labor and burnout, and whether the levels of self-efficacy and type A personality characteristics increase the risk of burnout in a sample of Korean female dental hygienists. Participants were 807 female dental hygienists with experience in performing customer service for o...
Purpose
Although γ-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome (MS), prospective data on baseline and longitudinal changes in GGT levels and incident cases of MS are limited. We aimed to examine prospective associations between changes in GGT levels over time, as well as at baseline, and incident MS in Korean ad...
Antibiotic resistance is steadily rising worldwide. Respiratory tract infections (RTIs) are common indications, mostly imprudent, for antibiotic prescriptions in outpatient setting. In Korea, antibiotic prescription rate for RTIs is still high. As physician visit and antibiotic prescribing are influenced by patient's perceptions and beliefs, we aim...
Objective: Although [gamma]-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome, prospective data on longitudinal changes in GGT levels and incident cases of metabolic syndrome are limited. Therefore, we examined the association between changes in GGT levels over time and incident metabolic syndrome.
Design and Method:...
Although central obesity is a more powerful predictor of cardiovascular disease (CVD) than general obesity, there is limited information on structural and functional changes of the heart in central obesity. Therefore, we evaluated the association between abdominal obesity and geometric and functional changes of the heart in healthy males. A total o...
Objective: Although g-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome, prospective data on longitudinal changes in GGT levels and incident cases of metabolic syndrome are limited. Therefore, we examined the association between changes in GGT levels over time and incident metabolic syndrome. Design and method: A tota...
Aims
The ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) is of great interest as a possible novel marker of metabolic syndrome. However, longitudinal studies emphasizing the incremental predictive value of the AST-to-ALT ratio in diagnosing individuals at higher risk of developing metabolic syndrome are very scarce. Ther...
All relevant data are available in the paper and its Supporting Information files.
(XLSX)
Table A. Baseline characteristics of the study subjects stratified by metabolic syndrome, and evaluation of the AST-to-ALT ratio in relation to the number of individual components of metabolic syndrome at baseline; Table B. Odds ratio and 95% confidence interval (CI) for the prevalence of metabolic syndrome according to the different quartiles of A...
Background: Disparity in adult mortality (AM) with reference to social dynamics and health care has not been sufficiently examined. This study aimed to identify the gap in the understanding of AM in relation to religion, political stability, economic level, and universal health coverage (UHC). Methods: A cross-national study was performed with diff...
The fatty liver index (FLI), calculated from serum triglyceride, body mass index, waist circumference, and gamma-glutamyltransferase, is considered a surrogate marker of nonalcoholic fatty liver disease (NAFLD). We investigated whether FLI predicts the development of diabetes mellitus (DM) and assessed the predictive ability of FLI for new onset of...
Irisin, a novel exercise-induced myokine, has been suggested to regulate energy homeostasis and insulin sensitivity. However, it remains unclear whether circulating irisin plays a role in the development of DM in human. We investigated the possible association between circulating irisin levels and incident DM in a 2.6-year longitudinal study of a p...
Fatty liver index changes according to incident hypertension
(DOCX)
Background:
Although non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood. We investigated whether fatty liver disease, as assessed by the fatty liver index, could predict the development of hypertension independently of systemic insulin resistance, inf...
To evaluate the performance of the American College of Cardiology/American Heart Association (ACC/AHA) 2013 Pooled Cohort Equations in the Korean Heart Study (KHS) population and to develop a Korean Risk Prediction Model (KRPM) for atherosclerotic cardiovascular disease (ASCVD) events.
The KHS cohort included 200,010 Korean adults aged 40-79 years...
Recent studies have demonstrated an association between serum uric acid (SUA) levels and metabolic syndrome (MetS). However, paucity of available data regarding the cause and effect relationship between SUA and MetS in healthy adults is still a big challenge which remains to be studied. Therefore, we investigated whether SUA predicts new onset of M...
Objective The objectives of this study were to develop a coronary heart disease (CHD) risk model among the Korean Heart Study (KHS) population and compare it with the Framingham CHD risk score.
Design A prospective cohort study within a national insurance system.
Setting 18 health promotion centres nationwide between 1996 and 2001 in Korea.
Partici...
To describe the rationale, objectives, protocol, and preliminary results for a new prospective cohort study of cardiovascular disease (CVD) risk factors in South Korea.
Study members were recruited from participants in routine health assessments at health promotion centres across South Korea. Established and emerging CVD risk factors were measured....
Interleukin-21 receptor (IL-21R) gene polymorphism is related with the development of systemic vasculitis. In this study, we investigated the polymorphisms of IL-21R gene in patients with Kawasaki disease (KD).
We genotyped the promoter region of IL-21R gene (-2500 bp to +1 bp) in 100 patients with KD and 100 healthy controls. All study subjects we...
People are generally exposed to radiation from natural sources. Radon is the most important radiation source among natural sources. Radon is a naturally occurring, radioactive noble gas that is odorless and tasteless. Radon is normally found at very low levels in outdoor air and in drinking water from rivers and lakes but higher levels in indoor ai...
Recently, the measurement of glycated hemoglobin (HbA1c) was recommended as an alternative to fasting plasma glucose or oral glucose tolerance tests for diagnosing diabetes mellitus (DM). In this study, we analyzed HbA1c levels for diabetes mellitus screening in a Korean rural population.
We analyzed data from 10,111 subjects from a Korean Rural Ge...
This study investigated the adverse health outcomes and urinary heavy metal levels in residents exposed to cement dust, compared to those who were not exposed. A total of 374 residents (276 for the exposed group and 98 for the unexposed group) were surveyed. Participant demographics, health-related behaviors (smoking and drinking), medical history,...
To assess three breast cancer risk assessment tools in obese rural Korean women.
Cross-sectional survey design.
Community settings in the rural region of northeastern South Korea.
A nested cohort sample of 64 severely obese women aged 40-60 years from the Korean Genomic Regional Cohort registry.
The Breast Cancer Risk Assessment Tool of the Nationa...
Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR).
This study include...
The aim of this study was to investigate the effect of simvastatin for preventing and treating osteoporosis compared to alendronate,
the standard treatment of choice in osteoporosis, in a rat model. Weight change, bone mineral density, and the bone volume/total
volume ratio obtained through histological analysis were used to compare the effects of...
Angiopoietin-related growth factor (AGF), a novel hepatokine, showed therapeutic implications in diabetic and obese animal models. Although the physiologic functions of human AGF have not yet been identified, serum levels of AGF displayed up-regulation in groups with diseases including preeclampsia and diabetes; and there was little association bet...
Carotid intima-media thickness (CIMT) is considered as a surrogate marker for cardiovascular disease (CVD). We determined the normative value of CIMT and correlates of CVD risk factors and Framingham risk score (FRS) in Korean rural middle-aged population. We measured CIMT with a B-mode ultrasonography in 1,759 subjects, aged 40 to 70 yr, in a popu...
Citations
... Other nutrients were calculated using the 2011 nutrient database of the Korean Nutrition Society [21], which is based on the seventh edition of the Korean Food Composition Table [20]. Especially, we used iron (Fe) and copper (Cu) as effect modifiers or confounders, because several reports indicate that certain flavonoids scavenge free radicals by chelating the deleterious oxidant-inducing metals such as iron and copper [22,23], which have been suggested to increase the risk of T2D [24][25][26]. ...
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... In addition, while we utilized a validated dietary assessment tool (FFQ), it was not specifically validated for flavonoids and Cu intake. Despite this limitation, our previously observed associations between flavonoids, Cu intake and the risks of hypertension [62], metabolic syndrome [63], and T2D [26], which were all based on mechanisms-based hypothesized relationships, may be a suggestive indirect evidence supporting the validity of estimated dietary data [64]. Second, low intake levels of certain flavonoids observed in cohorts, such as low flavone intake, may not have reached the biological effect threshold. ...
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... It targets the root causes of disease by motivating behavior change. It is rapidly becoming part of national health policies (Lee et al., 2023). Linkages between healthcare providers and social programs represent a holistic strategy for confronting persistent health inequities, addressing unmet psychosocial needs, and reducing health care office visits (Leavell et al., 2019). ...
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... In the present study, the CNN model was designed for processing 1D data, similar to previous research using CNNs for processing ECG data [8][9][10][11][12] . To the best of our knowledge, no widely used models have been designed for 1D ECG datasets, unlike models such as ResNet, which are designed for processing 2D images. ...
... The addition of negative pressure wound therapy, such as VAC dressing, can help accelerate wound closure and healing [15]. PG has been associated with a higher mortality risk when compared to the general population, and the prognosis can be improved with a multidisciplinary approach [16]. Although our patient lost follow-up and did not undertake treatment at our center, wound coverage could have been subsequently achieved using a skin graft and a muscle flap if required, with excellent outcomes over subsequent follow-ups [4][5][6][7][8][9][10][11][12]. ...
... According to the Global Burden of Disease 2019 [1], gynecologic cancer is the second most frequent cancer for young women aged 15-39 years, just behind breast cancer. Cancer survivors may have nearly twice risk of mental health problems compared to the general population [2], while gynecologic cancer survivors may have a higher risk of depression and anxiety than women with other cancers or without cancer [3]. According to previous studies [4,5], the prevalence of depression in gynecologic cancers ranged from 12.71 to 25.6%, and the prevalence of anxiety ranged from 19.12 to 27.09%. ...
... The primary outcome of the study was incident CKD, which was defined as the occurrence of two consecutive events with an eGFR of < 60 mL/min/1.73m 2 [21,22]. Participants who did not experience an incident CKD event during the exposure period were followed up from the end of the exposure period until the occurrence of an incident CKD event, the end of the study, or the last date of contact with the participant that provided informative data. ...
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... Moreover, MR analysis delved into the causal links between dietary habits and MD and MetS. We found that alcohol consumption elevates both conditions' risk, whereas coffee consumption seems to mitigate risk, aligning with extant cohort study outcomes [102][103][104][105] . These insights underscore the importance of healthy living in preventing and managing these conditions. ...
... Simultaneously, a thorough development of a new risk model will likely produce a best-case scenario performance-wise, which could serve as context for the external validation. Lastly, we note that four of the included studies validated multiple models [30,43,69,74]. ...
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... Historically, tattoos have been associated with blood-borne viruses (BBVs), specifically hepatitis B and C viruses (HBV, HCV) and human immunodeficiency virus (HIV) [7,8]. This correlation was likely due to historically poor infection prevention and control practices [9], plus a higher frequency of tattooing in people with other behaviours associated with these infections [10]. ...
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