October 2022
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23 Reads
Acta Mathematicae Applicatae Sinica
Joint analysis of multiple phenotypes can have better interpretation of complex diseases and increase statistical power to detect more significant single nucleotide polymorphisms (SNPs) compare to traditional single phenotype analysis in genome-wide association analysis. Principle component analysis (PCA), as a popular dimension reduction method, has been broadly used in the analysis of multiple phenotypes. Since PCA transforms the original phenotypes into principal components (PCs), it is natural to think that by analyzing these PCs, we can combine information across phenotypes. Existing PCA-based methods can be divided into two categories, either selecting one particular PC manually or combining information from all PCs. In this paper, we propose an adaptive principle component test (APCT) which selects and combines the PCs adaptively by using Cauchy combination method. Our proposed method can be seen as a generalization of traditional PCA based method since it contains two existing methods as special situation. Extensive simulation shows that our method is robust and can generate powerful result in various situations. The real data analysis of stock mice data also demonstrate that our proposed APCT can identify significant SNPs that are missed by traditional methods.