Sameep Naik's research while affiliated with Wright State University and other places
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Publications (2)
Background:
Skin melanocytes can give rise to benign and malignant neoplasms. Discrimination of an early melanoma from an unusual/atypical benign nevus can represent a significant challenge. However, previous studies have shown that in contrast to benign nevi, melanoma demonstrates pervasive chromosomal aberrations.
Objective:
This substantial d...
As new technologies come within reach for the average cytogenetic laboratory, the study of chromosome structure has become increasingly more sophisticated. Resolution has improved from karyotyping (in which whole chromosomes are discernible), to fluorescence in situ hybridization and comparative genomic hybridization (CGH, with which specific megab...
Citations
... Phenotypic variation may also be due to CNVs [6,14]. e data obtained from CNVs can also be used to classify tumors into malignant and benign [15,16]. A number of research articles agree that somatic CNVs are mostly associated with the progression of various cancers [17][18][19][20]. ...
... DNA isolated from FFPE tissue can be of poor quality with high rates of fragmentation related to storage time and fixation protocol [39]. Compared to other methods for DNA isolation from FFPE tissues, the QIAmp method used in our study has a higher DNA yield in terms of quantity, quality, and PCR performance [40][41][42]. However, DNA in FFPE tissue already shows significant fragmentation before isolation. ...
