S. Tsubaki's scientific contributions
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It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
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Publication (1)
Citations
... When Mn intake exceeds elimination, Mn can accumulate in mid-brain regions that influence motor control, such as the globus pallidus, striatum, and substantia nigra (Dorman et al., 2006b;Yamada et al., 1986), resulting in neurotoxicity. Similar neurological responses have been linked to prolonged inhalation exposures (Pal et al., 1999) or ingestion of drinking water with high concentrations of Mn (Kawamura, 1941), or in patients with liver disease resulting in impaired Mn clearance (Spahr et al., 1996), and with long-term parenteral nutrition (Fell et al., 1996). For human risk assessment, it is important to determine the exposure conditions that result in Mn concentrations in the brain that are increased significantly compared with brain Mn concentrations arising from normal dietary intake (Andersen et al., 1999). ...
