S R Spencer's research while affiliated with University College London and other places

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Publications (4)

Table 1 . 
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Pemble S, Shroeder KR, Spenser SR, Meyer DJ, Ketterer B, Taylor JBHuman glutathione S-transferase (GSTT1) cDNA cloning and the characterization of a genetic polymorphism. Biochem J 300: 271-276
Article
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  • Jun 1994
In humans, glutathione-dependent conjugation of halomethanes is polymorphic, with 60% of the population classed as conjugators and 40% as non-conjugators. We report the characterization of the genetic polymorphism causing the phenotypic difference. We have isolated a cDNA that encodes a human class Theta GST (GSTT1) and which shares 82% sequence id...
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The human glutathione S-transferase P1-1 gene: Modulation of expression by retinoic acid and insulin
Article
  • Jul 1993
Glutathione S-transferases (GSTs) are a group of enzymes which play an important role in the detoxication of xenobiotics. It is shown that the expression of human glutathione S-transferase P1-1 (GSTP1-1) is suppressed by retinoic acid (RA) as the result of decreased transcription from its gene, GSTP1. Chloramphenicol acetyltransferase (CAT) assays...
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The human mitochondrial NADH: Ubiquinone oxidoreductase 51-kDa subunit maps adjacent to the glutathione S-transferase P1-1 gene on chromosome 11q13
Article
  • Jan 1993
The soluble glutathione transferases (GSTs) are a family of dimeric isoenymes catalyzing the conjugation of glutathione to hydrophobic electropiles. Their subunits can be grouped into four families, alpha, mu, pi, and theta, on the basis of their primary structures. In man, the pi class is represented by a single gene, GSTP1-1 (GST[pi]) localized t...
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Citations

... Glutatyon metabolizmada meydana gelen serbest oksijen türlerinin yıkıcı etkilerine karsı hücreleri koruyan en önemli antioksidan maddelerden birisidir. Coles ve arkadaşlarının yaptığı çalışmada kanser patogenezinde GSH seviyelerinin normal sınırlar dışında kaldığı bildirilmiştir (Coles et al., 1990). Daduk'un mide kanserli hasta gruplarıyla yaptığı çalışmada mide kanserli hastalarda kan GSH seviyelerinin kontrollerle kıyaslandığında düşük olduğu buna karşın MDA seviyelerinin de aynı kıyaslamada az oranda artmış olduğu saptanmıştır (p<0.05). ...
Reference: Gastrit ve Mide Kanseri Hastalarında Kan Malondialdehit (MDA) ve Redükte Glutatyon(GSH) Düzeylerinin Araştırılması Investigation of Blood Malondialdehyde (MDA) and Reduced Glutathione (GSH) Levels in Gastritis and Gastric Cancer Patients
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... The NADH Dehydrogenase (Ubiquinone) Flavoprotein 1 (NDUFV1) is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which binds to the flavin mononucleotide using ubiquinone as an electron acceptor. It is a nuclear gene that encodes the 51 kDa subunit and forms the NADH-and FMN-binding site of complex I. 7 The NDUFV1 variant found in the homozygous/biallelic state in our patient has previously been reported at the compound heterozygous state in four patients: In one patient 8 (the variant is referred to as p.(Pro113Leu) with reference to transcript variant 2 (NM_001166102), onset was at age 1 year, with stroke, exercise intolerance, and leukodystrophy. Two others patients were sisters, 9 15 and 13 years of age, who showed mild learning disability and decreased visual acuity due to optic nerve atrophy. ...
Reference: Early-onset leukoencephalomyelopathy due to a biallelic NDUFV1 variant in a mid-forties patient
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... 38 GSTT1 is missing in many subjects (38% of Caucasians) due to a deletion mutation. 59 We have no information about interindividual variation in the processing of GSH conjugates to mercapturic acids apart from the textbook knowledge that serum γ-glutamyl transpeptidase in blood serum is elevated in hepatic diseases. ...
Reference: Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans
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... 38 The SNPs in regulatory elements (exonic, intronic, 5 0 -and 3 0 -UTRs) account for 2% of all mutations, but 66% of these SNPs are associated with diseases. 39 Based on data of Xia et al. 40 The deletion of three base pairs in intron 6 of human GSTM3 results in a new recognition sequence for the YY1 transcription factor. 46 This factor induces GSTM3 expression through the linking to the new motif. ...
Reference: Polymorphism of glutathione S‐transferase P1 of dogs with mammary tumors
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