S Nee's research while affiliated with University of Oxford and other places

Publications (14)

Article
Variable molecular sequences sampled from a population can be used to infer its dynamic history. Graphical methods are developed and applied to real data, illustrating ways of navigating through hypothesis space with two landmarks for reference: constant population size and exponentially growing population size.
Article
Phylogenetic trees play an increasing role in molecular epidemiology, where they have been used to understand the forces that shape patterns of viral sequence diversity. Phylogenetic trees can also be used to trace the dynamics of viral transmission within populations. Case studies document the worldwide spread of Human Immunodeficiency Virus type...
Article
Here we demonstrate how sex allocation theory, one of the best verified areas of metazoan evolutionary biology, can be successfully applied to microparasitic organisms, by relating parasite prevalence and sex ratio in the Haemosporina. Members of this taxon, which includes Plasmodium, are parasitic protozoa with obligate sexual cycles in which dioe...
Article
Full-text available
We apply new statistical methods to a recent estimate of the phylogeny of all living primate species to test a range of models of cladogenesis. Null models in which probabilities of speciation and extinction do not differ among contemporaneous lineages are not consistent with the phylogeny. We present evidence that the net rate of cladogenesis (spe...
Article
Molecular phylogenies can be used to reject null models of the way we think evolution occurred, including patterns of lineage extinction. They can also be used to provide maximum likelihood estimates of parameters associated with lineage birth and death rates. We illustrate: (i) how molecular phylogenies provide information about the extent to whic...
Article
Using distributional data on birds and mammals from various parts of the world, the authors use a combination of new and standard techniques to unravel contemporary and historical causes for range limitation They also address, at both theoretical and empirical levels, the relationships between local abundance and regional distribution, and explore...
Article
Full-text available
The analysis of the tempo and mode of evolution has a strong tradition in paleontology. Recent advances in molecular phylogenetic reconstruction make it possible to complement this work by using data from extant species.
Article
The frequency of recombination between unlike genotypes is central to understanding the generation of genetic diversity in natural populations of malaria. Here we suggest a way of investigating the problem which could complement conventional biochemical approaches to the population genetics of malaria. Sex allocation theory is one of the most succe...
Article
Full-text available
Molecular characterization of the Plasmodium falciparum genome has led to identification of polymorphic loci and the mechanisms generating genetic diversity in this parasite. This information has resulted in the development of molecular methods to type parasite diversity in the field. Consequently, we are now in a position to describe the populatio...

Citations

... Their presence as a distinguishing character of the family has been known for more than 100 years. The pedicellariae are arranged in raised bands around the arms of gorgonocephalids, often giving the arms an annulated appearance ( Fig. 1B-D Here we describe branching patterns in arms of the Euryalida and compare sister groups (Barraclough et al. 1998) to see what might be revealed by the distribution of branching and pedicellariae and the relative taxonomic diversity within this order of the Ophiuroidea. ...
... Although there are many speciation-extinction model simulation tools available (e.g. Herron, 2002;Höhna, May, & Moore, 2016;Maddison & Maddison, 2017;Rambaut, Grassly, Nee, & Harvey, 1996;Revell, 2012;Sukumaran & Holder, 2010;Webb, Ackerly, & Kembel, 2008), each tool is specific to a particular model class, or classes, and makes slightly different assumptions during simulations. Assumptions of when to stop a simulation, for example, vary. ...
... country (Owen and Camp, 2021;Owen and Cubilla, 2022). Many bat species reach the limit of their geographical distribution within the Paraguayan ecoregion mosaic (Koopman, 1982;Streilein, 1982), and the assembly of those species into local communities should reflect dynamic ecological and biogeographic features (Myers, 1982;Holt, 1993;Lawton et al., 1994). In a review of community ecology theory, Whitaker et al. (2001) noted that a current weakness of diversity theory included a failure to distinguish different biogeographical response variables under the general heading of diversity, and further that a general theory of diversity must necessarily cover many disparate phenomena, and cannot therefore be expressed in a simple formula. ...
... The diversity of living species on Earth results from a succession of speciation and extinction events. Starting in the 1990s with the pioneering work of Sean Nee and collaborators (Nee et al. 1992(Nee et al. , 1994, a wealth of studies have fitted birth-death models to phylogenetic trees to study these historical events (reviewed in Pennell & Harmon 2013, Stadler 2013, Morlon 2014. At the core of these studies are the rates at which speciation and extinction events occur, as well as their difference, referred to as the net diversification rate. ...
... Xanthurenic acid is found in high quantities in mosquito's head and gut and is utilised in the metabolism of eye pigment [34] . The stimulation of membrane associated guanyl cyclase activity via parasite cyclic guanyl mono phosphate (c-GMP) signalling pathway by xanthurenic acid results in exflagellation in the human malaria parasite [35] . Ghosh et al. demonstrated increased level of exflagellation in P. falciparum cultures which either used 0.2µM xanthurenic acid as a supplement or due to the presence of xanthurenic acid in the medium containing pupal extracts [15,36] . ...
... Sex ratios of natural and experimental infections of P. falciparum are well-known for being female biased (reviewed in [56]). LMC is a likely explanation because sex ratio correlates with the average genetic diversity of infections across populations, and within-host sex ratios correlate with the genetic diversity of individual infections [57][58][59][60][61]. Given the general explanatory power of LMC for taxa as diverse as insects and plants, plus P. chabaudi, it would be surprising if P. falciparum was an exception to the rule ( Table 2; from models to humans). ...
... One parasite factor affecting sex ratio is the competition between parasite clones [20,30,79]. It has been observed in multiclonal P. falciparum infections that each parasite clone produces a more male biased gametocyte population [30], indicating that competition between clones may favor a more even sex ratio, which was interpreted as a way to maximize each clone fertilization efficiency [30,35,80]. In human malaria infections, the presence of multiple genotypes may be explained by either subsequent infections or simultaneous acquisition of multiple clones from a single mosquito bite [81]. ...
... The informational and conceptual integration has projected comparative studies of primates far beyond the initial scope of comparative primatology over the past three decades (e.g. Purvis et al. 1995, Purvis & Webster 1999, Kamilar & Cooper 2013, Duran & Pie 2015, Kappeler & Pozzi 2019. Furthermore, boosted by computational modelling and data science, modern studies have built upon the longknown links among different features to predict a range of behavioural, ecological, and social aspects (e.g. ...
... In reality, the power-law fit is quite poor and should thus be rejected (Figures 6, S4, S5). Our findings are in agreement with previous studies that rejected the power-law behavior of compositional domains, although they relied on a small dataset and incomplete genomic sequences [56][57][58][59][60][61]. We reported similar findings in three ant genomes [19][20][21]. ...
... Phylogenetic trees are often applied to analyze the evolutionary relationships among viruses (Holmes et al., 1995;Lanciotti et al., 2002;Poon et al., 2013). Several studies have explored the phylogeny of SARS-CoV-2 using unrooted trees (Li et al., 2020a;Nabil et al., 2021), in which sampling time is used to specify a hypothetical root, resulting in the first detected sample being at the root. ...