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Publications (1)
Citations (1)
... In the death receptormediated pathway, after engagement of the specific ligand FasL, the cytoplasmic domain of death receptor Fas (APO-1/CD95) trimerizes and recruits the adaptor molecule Fas associated death domain (FADD). In turn, FADD recruits pro-caspase-8 to form the death-inducing signaling complex (DISC) in which caspase-8 is activated, leading to caspase-3 activation and apoptosis (Nagata, 1997). Caspase-8 can also activate Bcl-2 interacting domain (Bid), a proapoptotic member of the Bcl-2 family, by converting it to its truncated form, promoting apoptosis (Roy and Nicholson, 2000). ...
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