Ruoxi Zhang's research while affiliated with Harbin University and other places

... Additionally, the Hippo-YAP pathway has been implicated in arterial calci cation, which is a common feature of several vascular diseases, including diabetes-related vascular complications. Arterial calci cation involves the deposition of calcium phosphate crystals within the arterial walls, leading to stiffening and loss of elasticity [31]. YAP activity has been shown to modulate osteogenic differentiation of vascular smooth muscle cells, promoting their transition into calcifying cells that contribute to arterial calci cation. ...

... Yaoshi et al., (19) meta-analysis found that levosimendan administration significantly raised TAPSE in patients with heart dysfunction. Likewise, Chao Qu et al., (20) noted that in patients with acute decompensated right heart failure, use of levosimendan improved in the TAPSE. ...

... Given that KLF4 has been reported to directly or indirectly promote p21 transcription [15,16], some research suggests that KLF4 may act as a cell cycle repressor and senescence inducer [17]. In endothelial cells, KLF4 has also been demonstrated to induce pathologic senescence and the SASP through a p21-dependent manner in high glucose-treated endothelial cells [18]. However, it should be noted that KLF4 typically functions as an inducer of cellular pluripotency [19], and most studies have confirmed that KLF4 overexpression is very important to maintain a young cellular phenotype and suppress replicative senescence and physiological or pathological aging [4,7,20,21]. ...

... AMPK signaling has also been described to play an important role in inhibiting lipidinduced secretion of inflammatory cytokines, lipid uptake, and CD68 expression in vitro in VSMCs [75,76]. CD68 expression is associated with a more macrophage-like phenotype, suggesting the occurrence of VSMC phenotype switching [77]. ...

... Pathological CH refers to the typical enlargement of the heart (98). According to a recent study, MLK3 can promote pyroptosis of cardiomyocytes primarily via NFκB/NLRP3 (101). Another group reported that overexpression of the lncRNA TUG1 alleviated NLRP3-dependent pyroptosis of cardiomyocytes by regulating miR-186-5p/XIAP axis in a study on coronary microembolization (CME)-induced myocardial damage. ...

... There are increasing therapeutic strategies for cardio protection targeting autophagy [18,19]. In a previous study conducted by Yuan Yue, it was found that M2b macrophages play an antiapoptotic role in cardiomyocytes. ...

... It was also reported that decreased levels of TIMP-1 and IL-6 in plasma associated with the risk of ISR [11]. Liu et al. [12] also found that methotrexate promoted endothelial healing in ISR models by inhibiting inflammation levels. Endothelial cells (ECs) secrete inflammatory factors caused by stent implantation, which is thought to be the main cause of inflammation in vessels. ...

... A possible responsible mechanism could be the phosphorylation of p300 by AMPK, as this enzyme promotes nuclear factor kappa B (NF-κB) signaling [65]. Furthermore, AMPK signaling negatively regulates the production of reactive oxygen species (ROS) in mitochondria, which has been described as a potential mechanism for activation of the nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat (LRR)-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in ECs [66][67][68][69][70][71]. The NLRP3 inflammasome is a supramolecular protein complex that can be formed in a variety of cell types and controls the bioactivity and release of IL-1β, promoting further inflammation [72,73]. ...

... Liu et al. also reported a reduction in the intensity of atherogenesis caused by disturbed blood flow with MTX. MTX reduced the influx of monocytes and the development of inflammation that developed in response to disrupted flow [158]. ...

... According to previous study, nano polymer-free sirolimus-eluting stent was implanted to establish IRS rabbit model [19]. Briefly, 48 hours before procedure, adult New Zealand white rabbits (weight about 3-4 kg) received aspirin (40 mg) and clopidogrel (75 mg). ...