September 2022
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17 Reads
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5 Citations
New Journal of Chemistry
Highly permeable targeted chemotherapy is highly desired for treating non-small cell lung cancer (NSCLC). In this study, a novel stimulus-responsive, carrier-free, and triple-combination nano-system (identified as [email protected] nanoparticles [NPs]) is developed for the systemic treatment of ALK/EGFR dual-mutant NSCLC. This nanomedicine addresses concerns related to low drug loading and inefficient drug permeability and it provides the foundation for developing GSH-sensitive nanoparticles for improved drug delivery.