Rui He's research while affiliated with Qufu Normal University and other places

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Publications (1)


An activatable, carrier-free, triple-combination nanomedicine for ALK/EGFR-mutant non-small cell lung cancer high-permeable targeted chemotherapy
  • Article

September 2022

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17 Reads

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5 Citations

New Journal of Chemistry

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Yake Li

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[...]

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Peiwei Gong

Highly permeable targeted chemotherapy is highly desired for treating non-small cell lung cancer (NSCLC). In this study, a novel stimulus-responsive, carrier-free, and triple-combination nano-system (identified as [email protected] nanoparticles [NPs]) is developed for the systemic treatment of ALK/EGFR dual-mutant NSCLC. This nanomedicine addresses concerns related to low drug loading and inefficient drug permeability and it provides the foundation for developing GSH-sensitive nanoparticles for improved drug delivery.

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Citations (1)


... Combretastatin A4 (CA4), a natural stilbene derived from the bark of Combretum caffrum, has demonstrated promising anti-cancer properties, particularly in inhibiting the growth of blood vessels that supply nutrients to tumors [132,133]. Liu et al. have created a self-delivery nanomedicine named CeCA, which utilizes CA4 and Ce6 [81] (Fig. 5). This nanomedicine exhibits potential in improving chemo-photodynamic tumor therapy by disrupting tumor vasculature. ...

Reference:

Natural-product-based, Carrier-free, Noncovalent Nanoparticles for Tumor Chemo-photodynamic Combination Therapy
An activatable, carrier-free, triple-combination nanomedicine for ALK/EGFR-mutant non-small cell lung cancer high-permeable targeted chemotherapy
  • Citing Article
  • September 2022

New Journal of Chemistry