Roberta Mazzeo's research while affiliated with University Hospital Vall d'Hebron and other places
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Publications (31)
Introduction/Background
Recurrent gynecological tumors (eg, endometrial and ovarian cancers) are incurable diseases; therefore, new treatment options are urgently needed. The PTEN-AKT-PI3K pathway is frequently altered in these tumors, representing a potential treatment target. Alpelisib is an α-specific PI3K inhibitor approved in PIK3CA-mutated ad...
Introduction/Background
HRD identifies HGOC patients most likely to benefit from PARPi. Unlike commercially available genomic-scar HRD tests(CT), functional testing by RAD51, has potential to provide real-time readout of current HR status and may be more reliable to detect HRD.
Methodology
This single-institution study aims to assess immunofluores...
Introduction/Background
High-grade serous ovarian carcinoma (HGSC) remains the most lethal gynecologic cancer. However, there’s a patients’ subgroup with remarkable responses to treatment which have led to an exceptionally Long-Term Survival, namely >=10 years (LTS). How their clinical-molecular biomarkers might have determined their exceptionally...
Hormone receptor-positive/HER2 negative breast cancer (BC) is the most common subtype of BC and typically occurs as an early, operable disease. In patients receiving neoadjuvant chemotherapy (NACT), pathological complete response (pCR) is rare and multiple efforts have been made to predict disease recurrence and survival.
We developed a framework t...
Purpose of review
This review addresses the emerging role of antibody-drug conjugates (ADCs) in the treatment of ovarian cancer, a field marked by a high need for more effective and targeted therapies. Given the recent advancements in ADC technology and the ongoing challenges in treating ovarian cancer, particularly in late-stage and recurrent case...
Bartholin gland carcinoma is an extremely rare disease. Information regarding treatment is scarce and there is no strict consensus on best practice. All studies reporting cases of Bartholin’s gland cancer were screened and evaluated for inclusion. Baseline characteristics of studies were extracted. A total number of 290 manuscripts collected were a...
Precision medicine aims to improve healthcare by identifying subsets of patients that are more likely to benefit from specific treatment strategies. Liquid biopsy offers the unique potential to better understand and monitor disease biology, since it is not burdened by the temporal and spatial limitations of tissue biopsy. CTC (circulating tumor cel...
Hereditary cancer syndromes account for nearly 10% of cancers even though they are often underdiagnosed. Finding a pathogenic gene variant could have dramatic implications in terms of pharmacologic treatments, tailored preventive programs, and familiar cascade testing. However, diagnosing a hereditary cancer syndrome could be challenging because of...
Vulvar Paget’s disease (VPD) is a rare form of cutaneous adenocarcinoma of the vulva, which accounts for about 1–2% of all vulvar neoplasms and mainly affects post-menopausal women. The clinical presentation is usually non-specific and mimics chronic erythematous skin lesions; therefore, the diagnosis is often difficult and delayed. Although VPD is...
Background
Given the low chance of response to neoadjuvant chemotherapy (NACT) in luminal breast cancer (LBC), the identification of predictive factors of pathological complete response (pCR) represents a challenge. A multicenter retrospective analysis was performed to develop and validate a predictive nomogram for pCR, based on pre-treatment clini...
Introduction:
Neo/adjuvant therapy for early-stage breast cancer has become increasingly common in the last few decades; as a consequence, the number of breast cancer survivors experiencing often debilitating long-term side effects has increased, and thus the need for a comprehensive approach to the variety of symptoms involved.
Areas covered and...
Simple Summary: Intestinal-type adenocarcinoma (VAIt) is a very rare primary neoplasia of the vulva, which must be distinguished from other more usual adenocarcinomas. A real knowledge of VAIt origin, nature, and optimum management there is not yet. Therefore, we present here a systematic review that could be a useful tool for further discussion an...
5566
Background: As the prognosis of BRCA-related advanced ovarian cancer (AOC) continues to improve thanks to the introduction of targeted therapies like poly ADP-ribose polymerase inhibitors (PARPi) and bevacizumab, the occurrence of second primary tumors, in particular breast cancer (BC), is assumed to be more common. Despite this, data on the i...
Whole grains are a pivotal food category for the human diet and represent an invaluable source of carbohydrates, proteins, fibers, phytocompunds, minerals, and vitamins. Many studies have shown that the consumption of whole grains is linked to a reduced risk of cancer, cardiovascular diseases, and type 2 diabetes and other chronic diseases. However...
e16102
Background: Lactate dehydrogenase (LDH) is recognized as indirect marker of tumor hypoxia and angiogenesis for several solid tumors. Ramucirumab is the first antiangiogenic agent approved for second-line therapy in advanced gastric cancer (GC), alone or in association with chemotherapy. To date, no reliable biomarkers can predict the potenti...
1027
Background: The combination of ET and CDK4/6i is the current standard of care for hormone receptor (HR)-positive/HER2-negative MBC (luminal MBC), with neutropenia being the main dose limiting toxicity. We previously observed the potential association between leucocyte count (WBC) and different fractions of cell free circulating DNA (cfDNA) (Bo...
1033
Background: The exposure to endocrine therapy (ET) can induce the onset of ESR1 gene alterations that have an impact on not only treatment resistance but also clinical phenotype. We previously demonstrated the potential of liquid biopsy in describing the metastatic behavior of MBC. The aim of this study was to explore the different clinical ph...
e13008
Background: Liquid biopsy-based biomarkers, including circulating tumor DNA (ctDNA), are increasingly important for the characterization of metastatic breast cancer (MBC). Currently, CA15.3 is the most commonly used serum marker for monitoring disease burden. To date, no liquid biopsy-based biomarkers have been proposed for this scope in cli...
Background
Invasive vulvar Paget’s disease with over-expression of the human epidermal growth factor receptor 2 (HER2) protein is potentially suitable for targeted therapy, especially in a metastatic setting where no effective treatments are available.
Methods
Four consecutive patients with HER2 positive advanced vulvar Paget’s disease, treated wi...
Citations
... Las mutaciones espontáneas surgen como resultado de errores aleatorios en la replicación del DNA de las células en división y se adquieren en algún momento de la vida de cualquier individuo (Tomasetti & Vogelstein, 2015). También existen mutaciones heredadas por el padre o la madre que no son modificables y se asocian al desarrollo de cánceres heredados, los cuales son poco comunes, ya que solo representan del 5 al 10 % del total de todos los cánceres (Fearon, 1997;Lichtenstein et al., 2000;Jahn et al., 2022;Garutti et al., 2023). ...
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... Managing EMPD is complex due to the lack of standardized treatment protocols [3]. Surgical intervention, such as wide local excision or radical vulvectomy, is common for localized disease, yet recurrence rates range from 20 to 70% [3]. ...
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... Although chemotherapy is still the main form among the first-line treatment strategies for advanced NSCLC, the inevitable toxic side effects and the acquired resistance to these therapies remain significant clinical challenges [56]. In our study, lumbrokinase was found to enhance the efficacy of chemotherapeutics and to overcome their resistance to some extent via the targeted inactivation of the NF-κB/COX-2 signaling pathway. ...
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... It is mostly seen in women aged 42-69 yr and occur as polypoid lesions and mostly over the vestibule, fourchette. A recent study by Miriam Dellino et al. analyzed all cases of adenocarcinoma of intestinal variant and found that so far 29 cases of this tumor have been reported [29]. Histologically and immunohistochemically, they are indistinguishable from colorectal adenocarcinoma with intracytoplasmic mucin and goblet cells. ...
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... As the main crop and most commonly consumed staple food for the global population, grains are grown in more than 70% of the total harvested area in the world (Luithui et al., 2019). Whole grain foods possess more dietary fibre, vitamins, minerals and phytochemicals, compared with refined grains, and have been demonstrated to have various health benefits, such as lowering blood sugar and preventing chronic diseases (Garutti et al., 2022). Of all the whole grains, whole minor grains have received a lot of attention due to their superior health benefits. ...
... The case series further supported the role of baseline ANC as the co-occurrence of high C min levels and low ANC was observed in cases characterized by severe hematological toxicity (Iwata et al., 2021;Palmero et al., 2021). Patients with a high baseline ANC and a high C min could be still at risk of neutropenia, as in Case IV, and benefit from a dose reduction coupled with TDM monitoring. ...
... Genetically, LDHA is closely associated with various human metabolic cancer including pancreatic [32], laryngeal squamous cell carcinoma (LSCC) [33], head and neck [34], renal [35], gastric [36], prostate cancer [37], breast [38], hepatocellular [39], Oral Squamous Cell Carcinoma (OSCC) [40], and cervical cancer [41,42]. Extensive literature data confirmed that the LDHA inhibition showed a reduction in tumor proliferation in various cancers such as head and neck, pancreatic, cervical ad prostate cancer, and others [32,34,37,41,42]. ...
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... In the pursuit of novel therapeutic targets for EMPD, researchers have primarily concentrated on human epidermal growth factor receptor 2 (HER2), which is encoded by the ERBB2 gene 26,27 . Several sporadic cases have demonstrated promising results with HER2 antibody and chemotherapy combinations [28][29][30] . ...
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