Robert Gallop's research while affiliated with West Chester University and other places

Publications (252)

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Objective: To test potential cognitive and interpersonal moderators of two evidence-based youth depression prevention programs. Method: Two hundred four adolescents (Mage = 14.62 years, SD = 1.65; 56% female; 71% White, 11% Black, 11% multiracial, 5% Asian, 2% other races, 18% Hispanic/Latinx) were randomized to either a cognitive–behavioral (Copin...
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Introduction Brief interventions that reduce suicide risk following youth’s experience with acute care due to suicidality are needed. Methods and analysis The study will use a three-arm randomised controlled trial designed to test the effectiveness of the Safety Planning Intervention with structured follow-up (SPI+) and the Collaborative Assessmen...
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Unique trajectories of adolescent depression symptoms have been identified, yet less is known about whether such patterns translate to real-world clinical settings. Because annual adolescent depression screening is becoming more prevalent in primary care, we examined whether longitudinal patterns of depression symptoms documented in the development...
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Objective: Digital delivery of mindfulness-based cognitive therapy through the Mindful Mood Balance (MMB) program is clinically effective (Segal et al., 2020); however, the mechanisms through which this program delivers its benefits have not been established. Method: This study investigates the differential impact of the MMB program paired with...
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Purpose: Lung transplant (LT) centers are increasingly evaluating patients with multiple risk factors for adverse outcomes. Effects of these stacked risks remains unclear. Our aim was to determine the relationship between number of comorbidities and post-transplant outcomes. Methods: We performed a retrospective cohort study using the National I...
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Rationale: Both low and high body mass index (BMI) are associated with increased mortality after lung transplantation. Why extremes of BMI might increase risk of death is unknown. Objectives: To estimate the association of extremes of BMI with causes of death after transplantation. Methods: We performed a retrospective study of the UNOS databa...
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We evaluated the extent to which the web-based Mindful Mood Balance for Moms (MMB-M) course without coaching support was associated with improved mental health outcomes and changes in putative targets of self-compassion and decentering relative to a waitlist control. Sixty pregnant or early parenting women with depression histories were randomly as...
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Objective: Depression and stressors both increase during adolescence. The stress generation model posits that depression symptoms and associated impairment contribute to the generation of dependent stressors. Adolescent depression prevention programs have been shown to reduce the risk of depression. Recently, risk-informed personalization approach...
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Purpose Our goal was to develop brief pragmatic assessments of Behavioral Activation (BA) fidelity to support its dissemination in low-resource settings. Methods We used qualitative and quantitative methods across three investigations to develop pragmatic assessments rated from the perspective of therapists, patients, and observers: (1) we develop...
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Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a common and debilitating disease with poor treatment outcomes. Studies from the Multidisciplinary Approach to the study of chronic Pelvic Pain (MAPP) research network established that IC/BPS patients with chronic overlapping pain conditions (COPCs) experience poorer quality of life and more s...
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Self-control is often thought to be synonymous with willpower, defined as the direct modulation of impulses in order to do what is best in the long-run. However, research has also identified more strategic approaches to self-control that require less effort than willpower. To date, field research is lacking that compares the efficacy of willpower t...
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Objective To characterize Urologic Chronic Pelvic Pain Syndrome (UCPPS) pain and urinary symptom trajectories with up to 9 years of follow-up and evaluate whether initial 1-year trajectories are associated with longer-term changes. Materials and Methods Data were analyzed from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAP...
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Background We sought to describe trends in extracorporeal membrane oxygenation (ECMO) use, and define the impact on PGD incidence and early mortality in lung transplantation. Methods Patients were enrolled from August 2011 to June 2018 at 10 transplant centers in the multi-center Lung Transplant Outcomes Group prospective cohort study. PGD was def...
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Impaired insulin and incretin secretion underlie abnormal glucose tolerance (AGT) in pancreatic insufficient cystic fibrosis (PI-CF). Whether the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) can enhance pancreatic islet function in CF is not known. We studied 32 adults with PI-CF and AGT r...
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Depression and anxiety frequently co-occur and share several risk factors. There is some evidence for transdiagnostic effects of prevention programs on depression and anxiety. In the Personalized Depression Prevention (PDP) study, youth (n = 98, Mage = 13.94 years, SD = 1.67) were classified as high or low on cognitive and interpersonal risk factor...
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Treatment fidelity is a crucial consideration within randomized controlled trials (RCTs). The present study relies on data from a feasibility RCT conducted with 62 treatment-seeking suicidal college students. Issues of experimental fidelity were germane in this investigation because the same clinicians provided both the experimental (the Collaborat...
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Objective: Psychotherapy randomized trials rarely have tested for the best fitting model for time effects. We examined the fit of different statistical models for examining time when repeated assessments of depressive symptoms are the primary outcome. Method: We used data from three studies comparing psychotherapy treatments for major depressive...
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Introduction To develop an attribute-based method for assessing patient contraceptive preferences in Botswana and pilot its use to explore the relationship between patient contraceptive preferences and the contraceptive methods provided or recommended to patients by clinicians. Methods A list of contraceptive attributes was developed with input fr...
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Purpose Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. We previously developed an easy to use PGD predictive model utilizing the Lung Transplant Outcomes Group (LTOG) cohort. We therefore sought to demonstrate the net benefit of the model at an external site as a measure of model ge...
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Three categories of pain mechanisms are recognized as contributing to pain perception: nociceptive, neuropathic, and nociplastic (ie, central nervous system augmented pain processing). We use validated questionnaires to identify pain mechanisms in Urologic Chronic Pelvic Pain Syndrome (UCCPS) patients (n = 568, female = 378, male = 190) taking part...
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Purpose: 85% of women with interstitial cystitis/bladder pain syndrome (IC/BPS) and men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) have concomitant pelvic floor muscle tenderness (PFT). The significance of this finding is incompletely understood. This study examines PFT among participants in the MAPP Research Network, and its...
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Objective To examine trajectories of treatment response in suicidal youth who participated in a randomized controlled trial (RCT) comparing dialectical behavior therapy (DBT) and individual and group supportive therapy (IGST). Method Using latent class analysis across both treatment conditions, we conducted secondary analyses of data from a multis...
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Background To address the elevated prevalence of depression, suicide, and suicidal ideation, patients require increased access to effective interventions. Mindfulness-Based Cognitive Therapy has a strong evidence base in relapse prophylaxis and can be delivered digitally through Mindful Mood Balance (MMB). Methods This study was a secondary analys...
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Schools have the unique opportunity to identify and refer youth at risk for suicide. School-based gatekeeper training programs aim to improve staff’s ability to talk to students about mental health concerns and refer them for an assessment. Unfortunately, progress in evaluating the available programs has been limited. In fact, the popular and widel...
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Context Cross-sectional studies have identified an increased risk of metabolic syndrome (MetSyn) in women with polycystic ovary syndrome (PCOS), but longitudinal data are limited and primarily include White and European cohorts. Objective To compare the longitudinal risk of MetSyn in Black and White women with PCOS and to identify potential factor...
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Purpose: Impaired incretin secretion may contribute to the defective insulin secretion and abnormal glucose tolerance (AGT) that associate with worse clinical outcomes in pancreatic insufficient cystic fibrosis (PI-CF). The study objective was to test the hypothesis that dipeptidyl peptidase-4 (DPP-4) inhibitor-induced increases in intact incretin...
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Purpose: Impaired incretin secretion may contribute to the defective insulin secretion and abnormal glucose tolerance (AGT) that associate with worse clinical outcomes in pancreatic insufficient cystic fibrosis (PI-CF). The study objective was to test the hypothesis that dipeptidyl peptidase-4 (DPP-4) inhibitor-induced increases in intact incretin...
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In psychotherapy research, adherence refers to the extent to which therapists deliver a treatment as intended. This study examined whether therapist adherence to two different manualized treatments was associated with improved client outcomes and whether the association was moderated by therapeutic alliance. The study sample included 320 video reco...
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Purpose Priority on waitlist urgency over post-transplant survival has decreased waitlist mortality with no appreciable change in short to mid-term survival. We sought to define the effects of increased pressure to transplant sicker candidates on PGD incidence and mortality as a leading indicator for long-term effects. Methods We used the multi-ce...
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Purpose Studies have shown in solid organ transplantation that multiple listing is advantageous. We therefore performed this study to determine if disparities in multiple listing exist and if differences in LAS between multiple listed (ML) and single listed (SL) candidates affect transplantation and survival rates. Methods We conducted a retrospec...
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Objective To evaluate racial differences in anxiety and depression prevalence and scores in women with polycystic ovary syndrome (PCOS). Design Cross-sectional Setting Academic institution Patients Reproductive-aged with PCOS (n=272) and Controls (n=295) Intervention Hospital Anxiety and Depression Scale (HADS) and modified PCOS Quality of Life...
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Objective This study evaluated mechanisms, mediation, and secondary/exploratory outcomes in our randomized controlled trial evaluating Dialectical Behavior Therapy (DBT) compared to Individual and Group Supportive Therapy (IGST), expanding on previously reported results indicating a DBT advantage at post-treatment on planned suicide/self-harm outco...
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Objectives One core assumption of mindfulness interventions is that engagement via session attendance and at-home mindfulness practices is essential to the program’s efficacy. In two samples of pregnant women who underwent Mindfulness-Based Cognitive Therapy for Perinatal Depression (MBCT-PD), we aimed to evaluate predictors of engagement as well a...
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Objective To evaluate whether evidence-based depression prevention programs can be optimized by matching youth to interventions that address their psychosocial vulnerabilities. Method This randomized controlled trial included 204 adolescents (M = 14.26 years, SD = 1.65; 56.4% female). Youth were categorized as high or low on cognitive and interper...
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Objective To determine the rate of utilization, factors influencing the decision-making process, and patient satisfaction with preimplantation genetic diagnosis for monogenic disorders (PGT-M). Design Survey study. Setting Academic center. Patient(s) Genetically at-risk patients seen for PGT-M consultation between January 2010 and 2018. Interve...
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Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST) is an evidence-based indicated depression prevention program that has been shown to reduce depression symptoms. Research is needed to identify moderators of IPT-AST’s effects. Although trauma history has emerged as a moderator of depression treatment outcomes, the impact of trauma on...
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Background Among women with polycystic ovary syndrome (PCOS), there is a higher prevalence of cardiometabolic risk factors compared to women without PCOS. Postpartum weight retention has been shown to contribute to these risks in the general population, but little is known about postpartum weight retention among women with PCOS. Objective(s): To co...
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Few studies examine the benefits from geriatric telepsychiatry in rural retirement communities. Objectives: 1. To demonstrate that using telepsychiatry a) standard approaches to psychiatric evaluation would yield diagnoses in Diagnostic and Statistical Manual of Mental Disorders (DSM-V); b. psychotherapies and pharmacotherapy could be effectively a...
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This randomized controlled trial compared the Collaborative Assessment and Management of Suicidality (CAMS) and Treatment as Usual (TAU) for suicidal college students within a feasibility trial. Sixty-two suicidal college students were randomized to CAMS (n = 33) or TAU (n = 29). We hypothesized that those receiving CAMS would show more improvement...
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Purpose ECMO is increasingly used for bridging and salvage therapies in lung transplantation, with favorable short-term results. Mid- to long-term outcomes of ECMO use for bridging and salvage are incompletely understood, as is effect on PGD risk; therefore, we sought to define the effects of these strategies on mortality and PGD. Methods The Lung...
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To examine process of changes in two distinct psychotherapies-cognitive-behavioral therapy (CBT) and Panic-Focused Psychodynamic Psychotherapy (PFPP). Two hypothesized processes of change-misinterpretation of bodily sensations and Panic Specific Reflective Function (PSRF)-were tested in the CBT and PFPP arms of the Cornell-Penn Study of Psychothera...
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Importance Patients with residual depressive symptoms face a gap in care because few resources, to date, are available to manage the lingering effects of their illness. Objective To evaluate the effectiveness for treating residual depressive symptoms with Mindful Mood Balance (MMB), a web-based application that delivers mindfulness-based cognitive...
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Importance Antidepressant medication treatment is associated with the prevention of depressive recurrence in patients with major depressive disorder (MDD), but whether cognitive behavioral therapy (CBT) treatment is associated with recurrence prevention remains unclear. Objective To determine the effects of combining CBT with antidepressant medica...
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When predicting success, how important are personal attributes other than cognitive ability? To address this question, we capitalized on a full decade of prospective, longitudinal data from n = 11,258 cadets entering training at the US Military Academy at West Point. Prior to training, cognitive ability was negatively correlated with both physical...
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Several adolescent depression prevention programs have demonstrated effects on depressive symptoms and overall functioning. Yet, despite an increasing emphasis on elucidating mechanisms of change in interventions, few studies have identified mediators of these preventive interventions. In this study, we examined interpersonal mediators of Interpers...
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Background In primary analyses, dialectical behavior therapy (DBT) was associated with greater reduction in self‐harm during treatment than individual/group supportive therapy (IGST). The objective of this paper was to examine predictors and moderators of treatment outcomes for suicidal adolescents who participated in a randomized controlled trial...
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Objective: Our goal was to evaluate treatment attendance patterns, including both treatment completion and premature termination from treatment, for 2 evidence-based psychotherapies for major depressive disorder (MDD) delivered in a community mental health setting. We explored rates of premature termination across the course of treatment as well a...
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Abstract Experimental pain sensitivity was assessed in individuals with urologic chronic pelvic pain syndrome (UCPPS) as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. A series of computer-controlled pressure stimuli were delivered to the thumbnail bed, an asymptomatic site distant from the area...
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Objective To describe the frequency, intensity and duration of urological chronic pelvic pain syndrome symptom exacerbations (‘flares’), as well as risk factors for these features, in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Epidemiology and Phenotyping longitudinal study. Participants and Methods Current flare status (‘u...
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Purpose Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplant. Studies have identified the intraoperative use of cardiopulmonary bypass (CPB) as a risk factor for PGD. There has been an increase in the use of extracorporeal membrane oxygenation (ECMO) for intraoperative support over the last dec...
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Background: Given the prevalence and consequences of adolescent depression, depression prevention has become an important area of research. While prevention programs like Interpersonal Psychotherapy - Adolescent Skills Training (IPT-AST) have demonstrated effectiveness, little research to date has studied the relationship between maternal depressi...
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Purpose: The time course of adverse events is an important factor for patient management. Clinicians are better able to prepare patients for specific adverse events, which leads to better treatment adherence. Methods: Adverse events were followed longitudinally for 6 months during the open-label phase of a relapse prevention trial with 264 patie...
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Objective: To introduce readers to instrumental variable analyses for causal inferences using as an example a test of the hypothesis that the quality of the therapeutic alliance has a causal role in relation to the outcome of psychotherapy. Method: We used data from a recent non-inferiority trial of cognitive and dynamic therapies for major depr...
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Objectives: The Pennsylvania Chronic Care Initiative (CCI) was a statewide patient-centered medical home (PCMH) initiative implemented from 2008 to 2011. This study examined whether the CCI affected utilization and costs for HIV-positive Medicaid patients with both medical and behavioral health comorbidities. Study design: Nonrandomized comparis...
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Adolescence represents a vulnerable developmental period for depression and an opportune time for prevention efforts. In this study, 186 adolescents with elevated depressive symptoms (M age = 14.01, SD = 1.22; 66.7% female; 32.2% racial minority) were randomized to receive either Interpersonal Psychotherapy–Adolescent Skills Training (IPT-AST; n =...
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Importance Suicide is a leading cause of death among 10- to 24-year-old individuals in the United States; evidence on effective treatment for adolescents who engage in suicidal and self-harm behaviors is limited. Objective To evaluate the efficacy of dialectical behavior therapy (DBT) compared with individual and group supportive therapy (IGST) fo...
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The purpose of this paper is to reanalyze data from two studies to determine if anhedonia specifically, rather than depression overall, predicts treatment outcome for patients with cocaine use disorders. Measures of baseline anhedonia symptoms were created using anhedonia items from the Beck Depression Inventory (BDI) to re-examine National Institu...
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Chronic Overlapping Pain Conditions (COPCs) are characterized by aberrant central nervous system processing of pain. This 'centralized pain' phenotype has been described using a large and diverse set of symptom domains, including the spatial distribution of pain, pain intensity, fatigue, mood imbalances, cognitive dysfunction, altered somatic sensa...
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Despite interest in psychosocial vulnerabilities to depression, little is known about reliable and valid individualized risk profiles that can be used to match individuals to evidence-based interventions for depression. This study investigated well-established cognitive and interpersonal vulnerabilities to depression among youth to discern an evide...
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Objectives: This pilot study investigated the potential to utilize adaptive treatment strategies for treating moderate to severe suicidal risk among college students. This paper will describe the unique design and report on feasibility and acceptability findings. Methods: A two-stage Sequential Multiple Assignment Randomized Trial (SMART) was co...
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Background: No studies of psychotherapies for panic disorder (PD) have examined effects on comorbid personality disorders (PersD), yet half such patients have a PersD. Methods: In a randomized trial for PD with and without agoraphobia comparing Cognitive-Behavioral Therapy (CBT) and Panic-Focused Psychodynamic Psychotherapy (PFPP), PersD was ass...
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Purpose: Although many factors have been proposed to trigger symptom exacerbations ("flares") in patients with interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, few studies have investigated these factors empirically. Therefore, we embedded a case-crossover study in the Multidisciplinary Approach to...
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We developed three methods (rating, ranking, and discrete choice) for identifying patients’ preferred depression treatments based on their prioritization of specific treatment attributes (e.g., medication side effects, psychotherapy characteristics) at treatment intake. Community mental health patients with depressive symptoms participated in separ...
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Objective: The memory-enhancing drug methylene blue (MB) administered after extinction training improves fear extinction retention in rats and humans with claustrophobia. Robust findings from animal research, in combination with established safety and data showing MB-enhanced extinction in humans, provide a foundation to extend this work to extinc...
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Objective: To identify variables predicting psychotherapy outcome for panic disorder or indicating which of 2 very different forms of psychotherapy-panic-focused psychodynamic psychotherapy (PFPP) or cognitive-behavioral therapy (CBT)-would be more effective for particular patients. Method: Data were from 161 adults participating in a randomized...
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Background The Chronic Care Initiative (CCI) was a large state-wide patient-centered medical home (PCMH) initiative in Pennsylvania in place from 2008–2011. Objective Determine whether the CCI impacted the utilization and costs for Medicaid patients with chronic medical conditions and comorbid psychiatric or substance use disorders. Design Analysis...
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Objective: This study examined the relation of change in theory-relevant cognitive variables to depressive symptom change over the course of cognitive therapy, as well as the specificity of change mechanisms to cognitive therapy as compared with dynamic therapy. Method: There were 237 adult outpatients who were randomized to either cognitive (n...
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Objective: Depression among pregnant women is a prevalent public health problem associated with poor maternal and offspring development. Behavioral activation (BA) is a scalable intervention aligned with pregnant women’s preference for nonpharmacological depression care. This is the first test of the effectiveness of BA for depression among pregnan...
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Alterations in the functional relationship between a hyperactive amygdala and hypoactive ventral medial prefrontal cortex in posttraumatic stress disorder (PTSD), suggests an underlying faulty inhibitory neural mechanism. Prolonged exposure (PE) and sertraline are treatments that are thought to normalize interactions between these brain regions; wi...
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Background: The efficacy of acceptance and commitment therapy (ACT) in psychosis has been reported but not for medication-resistant psychosis. Aims: To test the efficacy of ACT in a sample of community-residing patients with persisting psychotic symptoms. (Australian New Zealand Clinical Trials Registry: ACTRN12608000210370.) METHOD: The primary...
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Objective: The purpose of this study was to examine the validity of the Psychological Distance Scaling Task (PDST), a measure of cognitive schema organization, in a community mental health setting. We also compared validity among African Americans and Caucasians. Method: In order to accommodate participants with low education levels, 26 out of 8...
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Objective: The Ways of Responding (WOR) instrument measures compensatory skills, a central construct in some theories of the mechanism of cognitive therapy for depression. However, the instrument is time-consuming and expensive to use in community settings, because it requires trained independent judges to rate subjects' open-ended written respons...
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This randomized controlled trial examined the longitudinal effects of two school-based indicated depression prevention programs on adolescents’ internalizing and externalizing symptoms, as measured by adolescents, their parents, and their teachers. One hundred eighty-six adolescents participated in this study. The average age was 14.01 (SD = 1.22)...
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Importance: Dynamic psychotherapy (DT) is widely practiced in the community, but few trials have established its effectiveness for specific mental health disorders relative to control conditions or other evidence-based psychotherapies. Objective: To determine whether DT is not inferior to cognitive therapy (CT) in the treatment of major depressi...
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The purpose of this study was to compare the naturalistic outcomes of individuals with alcohol or opioid use problems who were treated with extended-release naltrexone (XR-NTX) to those treated with psychosocial treatment only and also to those treated with other medication-assisted therapies in Missouri during 2010 to 2011. We analyzed intake and...
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To the Editor We write to report that we have discovered a number of pervasive errors in our published trial comparing recovery rates for major depressive disorder with cognitive therapy and medication vs medication alone (Effect of Cognitive Therapy With Antidepressant Medications vs Antidepressants Alone on the Rate of Recovery in Major Depressiv...
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Objective: Attentional inhibitory deficits expressed as difficulty ignoring irrelevant stimuli in the pursuit of goal-directed behavior may serve as a fundamental mechanism of posttraumatic stress disorder (PTSD). Evidence of inhibitory processes as central to extinction suggests that exposure-based treatments may act more directly on the inhibito...
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Objective: Clinical decision-making regarding the prevention of depression is complex for pregnant women with histories of depression and their health care providers. Pregnant women with histories of depression report preference for nonpharmacological care, but few evidence-based options exist. Mindfulness-based cognitive therapy has strong evidenc...
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Given the rise in depression disorders in adolescence, it is important to develop and study depression prevention programs for this age group. The current study examined the efficacy of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), a group prevention program for adolescent depression, in comparison to group programs that are typ...
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Objective: To compare cognitive-behavioral therapy (CBT), panic-focused psychodynamic psychotherapy (PFPP), and applied relaxation training (ART) for primary DSM-IV panic disorder with and without agoraphobia in a 2-site randomized controlled trial. Method: 201 patients were stratified for site and DSM-IV agoraphobia and depression and were random...
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We describe the development and evaluation of a clinician feedback intervention for use in community mental health settings. The Community Clinician Feedback System (CCFS) was developed in collaboration with a community partner to meet the needs of providers working in such community settings. The CCFS consists of weekly performance feedback to cli...
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Objective The contributions of disorder severity, comorbidity and interpersonal variables to therapists' adherence to a cognitive-behavioural treatment (CBT) manual were tested.Method Thirty-eight patients received panic control therapy (PCT) for panic disorder. Trained observers watching videotapes of the sixth session of a 24-session protocol rat...
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Inhibition of fear generalization with new learning is an important process in treatments for anxiety disorders. Generalization of maladaptive cognitions related to traumatic experiences (overgeneralized beliefs) have been demonstrated to be associated with posttraumatic stress disorder (PTSD) in adult populations, whereas more balanced, accommodat...
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Count responses with structural zeros are very common in medical and psychosocial research, especially in alcohol and HIV research, and the zero-inflated Poisson (ZIP) and zero-inflated negative binomial models are widely used for modeling such outcomes. However, as alcohol drinking outcomes such as days of drinkings are counts within a given perio...
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Abstract Objective: The goal of the study was to evaluate whether enhanced normative feedback recovery curves are needed for treatment of substance use problems. Method: Patient predictors of outcome were examined using data from four substance abuse treatment clinics. Results: Baseline severity of symptoms/functioning, employment, and craving were...
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Childhood socioeconomic status (SES) predicts executive function (EF), but fundamental aspects of this relation remain unknown: the developmental course of the SES disparity, its continued sensitivity to SES changes during that course, and the features of childhood experience responsible for the SES–EF relation. Regarding course, early disparities...

Citations

... Although some commonly used meta-analytic methods (e.g., weighting study-level effect size estimates by the inverse of their variance, using trim-and-fill analyses to estimate the impact of publication bias) can address some of the limitations of small sample studies particularly when sufficient primary studies are included, meta-analytic inferences based on such data are not immune from small sample biases and may therefore lead to erroneous conclusions (Lin, 2018;Simonsohn et al., 2022). While a couple of well-powered studies on mediators in MBIs have been conducted (e.g., Dimidjian et al., 2023), the field of MBI research has produced little strong evidence of statistical mediation and as a consequence, a dearth of knowledge to advance research toward a causal understanding of MBI effects. ...
... Secondly, reactive oxygen species generated by an influx of cytosolic calcium during warm and cold ischemic times in response to ATP generation creates a cycle of inflammatory changes and eventual endothelial damage, which leads to more inflammation from increased capillary permeability and cytokine release, ultimately leading to cell death in the donor allograft (6,7). Furthermore, the milieu of donor and recipient risk factors, which we will discuss in this article, are also key in the pathophysiology of PGD (8,9). Importantly, PGD is strongly associated with the development of chronic lung allograft dysfunction (CLAD), which is the primary cause of long-term morbidity and mortality after LTx (10,11). ...
... However, 25 recipients were excluded of analysis of donor's BMI, as this data was not available. Median BMI in the all cohort was 24 [21][22][23][24][25][26][27] Kg/m 2 for the recipients, and 24 [21][22][23][24][25][26][27] Kg/m 2 for donors. Median weight of recipients was 70[58-80] Kg. 41 (13%) recipients were underweighted, 130 (43%) recipients had a normal pretransplantation BMI, and 133 (44%) recipients were overweighted or obese (36 (12%) obese recipients, including 35 class I obesity (BMI 30-34.9 ...
... Consistent with our previous analyses using these data (Jones et al., 2022(Jones et al., , 2024Young et al., 2021), we included adolescent age, ethnicity, and lifetime depression diagnosis as covariates in all models. These covariates are time-invariant; therefore, they were included in our level 2 models as covariates for the subject-specific intercept as outcome, the subject-specific active phase slope as outcome, and the subject-specific follow-up phase slope as outcome. ...
... have demonstrated heightened expression of proinflammatory cytokines in endotoxin-stimulated human whole blood and peripheral blood mononuclear cells obtained from women with pelvic pain (Evans et al., 2020;Schrepf et al., 2023). Additionally, a recent study conducted by our team revealed altered temperature and metabolic responses in response to in vivo endotoxin administration in women with FM (Mueller et al., 2023). ...
... The disposition to act, think, and feel in ways that are advantageous to people and society is referred to as strength of character (Baldwin, 2022;Chopik, 2022;Duckworth, 2015;Peterson, 2007). Character qualities, also known as virtues, life skills, soft skills, social and emotional learning competencies, learning mindsets, developmental assets, and non-cognitive skills, are often referred to as character strengths. ...
... 5,6 Multiple studies have reported that PGD is associated with prolonged length of mechanical ventilation, intensive care unit (ICU) stay, increased costs and short-term mortality. 7,8 PGD shares clinical and pathological similarities with acute respiratory distress syndrome (ARDS). 9 Interestingly, several studies have shown an association between high driving pressure and poor outcomes in patients with ARDS. ...
... Approximately 75% of patients experience pain outside of the pelvis, suggesting the presence of a centralized pain phenotype Lai et al., 2017). Patients of both genders experience high rates of painful bladder filling and urinary urgency, and up to 20% report sporadic symptom flares (Bradley et al., 2022;Clemens et al., 2007;Lai et al., 2015). The symptom flares usually increase pain and impact QoL (Sutcliffe et al., 2015;Sutcliffe et al., 2023). ...
... DRG insulin ELISA kit was used to determine serum insulin concentrations. 9 [fasting insulin (ng/ml)] [fasting glucose (mg/dl)]/405 is the homeostasis model of IR (HOMA-IR). 10 Preptin level was determined by (ELISA) method using. ...
... Consistent with our previous analyses using these data (Jones et al., 2022(Jones et al., , 2024Young et al., 2021), we included adolescent age, ethnicity, and lifetime depression diagnosis as covariates in all models. These covariates are time-invariant; therefore, they were included in our level 2 models as covariates for the subject-specific intercept as outcome, the subject-specific active phase slope as outcome, and the subject-specific follow-up phase slope as outcome. ...