Rey Edison's research while affiliated with Massachusetts Institute of Technology and other places
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Publications (6)
Custom DNA synthesis underpins modern biology, but hazardous genes in the wrong hands could threaten many lives and public trust in science. In 1992, a virology-trained mass murderer tried and failed to obtain physical samples of Ebola; today, viruses can be assembled from synthetic DNA fragments. Screening orders for hazards is unreliable and expe...
Fertility‐targeted gene drives have been proposed as an ethical genetic approach for managing wild populations of vertebrate pests for public health and conservation benefit. This manuscript introduces a framework to identify and evaluate target gene suitability based on biological gene function, gene expression and results from mouse knockout mode...
Fertility-targeted gene drives have been proposed as an ethical genetic approach for managing wild populations of vertebrate pests for public health and conservation benefit.
This manuscript introduces a framework to identify and evaluate target gene suitability based on biological gene function, gene expression, and results from mouse knockout mod...
The promise of biotechnology is tempered by its potential for accidental or deliberate misuse. Reliably identifying telltale signatures characteristic to different genetic designers, termed ‘genetic engineering attribution’, would deter misuse, yet is still considered unsolved. Here, we show that recurrent neural networks trained on DNA motifs and...
The promise of biotechnology is tempered by its potential for accidental or deliberate misuse. Reliably identifying telltale signatures characteristic to different genetic designers, termed genetic engineering attribution, would deter misuse, yet is still considered unsolved. Here, we show that recurrent neural networks trained on DNA motifs and ba...
Natural selection cares nothing for animal suffering. However, it is artificial selection that governs the genetics of billions of domesticated animals and consequently their predisposition to well-being. Even without directed research, future insights into the genetics of mood will almost certainly enable us to substantially improve the lives of t...
Citations
... It correctly identified the source lab 48% of the time and the source lab appeared in the top 10 predicted labs 70% of the time. A comparable method, deteRNNt, used recurrent neural networks trained on plasmid sequences and associated phenotype data to identify DNA motifs indicative of different genetic designers [53]. It demonstrated an improvement in accuracy to 70% correct attribution to one lab among 1,300 in the dataset. ...
... This will prevent plagiarism, encourage responsible development, allow designers to gain due credit and as an approach to holding genetic engineers/designers accountable for their work. Tools for attributing this biotechnology to their owners, often referred to genetic engineering attribution (GEA), have only recently become sufficiently well-performing [1,31,43]. ...
... In "On Mitigating the Cruelty of Natural Selection Through Humane Genome Editing," gene drive researchers Rey Edison and Kevin M. Esvelt [17] consider the possibility that future insights into the genetics of mood will enable us to substantially improve the lives of trillions of agricultural animals. Breeding and artificial selection already govern the genetics of billions of domesticated animals, as well as their predisposition to well-being. ...
